| 13 Aug 21 | r01      | BrentfordBrentford | 2 - 0 | ArsenalArsenal |
| 14 Aug 21 | r01 | Manchester UnitedManchester Un | 5 - 1 | LeedsLeeds |
| 14 Aug 21 | r01 | BurnleyBurnley | 1 - 2 | BrightonBrighton |
| 14 Aug 21 | r01 | ChelseaChelsea | 3 - 0 | Crystal PalaceCrystal Palac |
| 14 Aug 21 | r01 | EvertonEverton | 3 - 1 | SouthamptonSouthampton |
| 14 Aug 21 | r01 | LeicesterLeicester | 1 - 0 | WolvesWolves |
| 14 Aug 21 | r01 | WatfordWatford | 3 - 2 | Aston VillaAston Villa |
| 14 Aug 21 | r01 | NorwichNorwich | 0 - 3 | LiverpoolLiverpool |
| 15 Aug 21 | r01 | NewcastleNewcastle | 2 - 4 | West HamWest Ham |
| 15 Aug 21 | r01 | TottenhamTottenham | 1 - 0 | Manchester CityManchester Ci |
| |
| 21 Aug 21 | r02 | LiverpoolLiverpool | 2 - 0 | BurnleyBurnley |
| 21 Aug 21 | r02 | Aston VillaAston Villa | 2 - 0 | NewcastleNewcastle |
| 21 Aug 21 | r02 | Crystal PalaceCrystal Palac | 0 - 0 | BrentfordBrentford |
| 21 Aug 21 | r02 | LeedsLeeds | 2 - 2 | EvertonEverton |
| 21 Aug 21 | r02 | Manchester CityManchester Ci | 5 - 0 | NorwichNorwich |
| 21 Aug 21 | r02 | BrightonBrighton | 2 - 0 | WatfordWatford |
| 22 Aug 21 | r02 | SouthamptonSouthampton | 1 - 1 | Manchester UnitedManchester Un |
| 22 Aug 21 | r02 | WolvesWolves | 0 - 1 | TottenhamTottenham |
| 22 Aug 21 | r02 | ArsenalArsenal | 0 - 2 | ChelseaChelsea |
| 23 Aug 21 | r02 | West HamWest Ham | 4 - 1 | LeicesterLeicester |
| |
| 28 Aug 21 | r03 | Manchester CityManchester Ci | 5 - 0 | ArsenalArsenal |
| 28 Aug 21 | r03 | Aston VillaAston Villa | 1 - 1 | BrentfordBrentford |
| 28 Aug 21 | r03 | BrightonBrighton | 0 - 2 | EvertonEverton |
| 28 Aug 21 | r03 | NewcastleNewcastle | 2 - 2 | SouthamptonSouthampton |
| 28 Aug 21 | r03 | NorwichNorwich | 1 - 2 | LeicesterLeicester |
| 28 Aug 21 | r03 | West HamWest Ham | 2 - 2 | Crystal PalaceCrystal Palac |
| 28 Aug 21 | r03 | LiverpoolLiverpool | 1 - 1 | ChelseaChelsea |
| 29 Aug 21 | r03 | BurnleyBurnley | 1 - 1 | LeedsLeeds |
| 29 Aug 21 | r03 | TottenhamTottenham | 1 - 0 | WatfordWatford |
| 29 Aug 21 | r03 | WolvesWolves | 0 - 1 | Manchester UnitedManchester Un |
| |
| 11 Sep 21 | r04 | Crystal PalaceCrystal Palac | 3 - 0 | TottenhamTottenham |
| 11 Sep 21 | r04 | ArsenalArsenal | 1 - 0 | NorwichNorwich |
| 11 Sep 21 | r04 | BrentfordBrentford | 0 - 1 | BrightonBrighton |
| 11 Sep 21 | r04 | LeicesterLeicester | 0 - 1 | Manchester CityManchester Ci |
| 11 Sep 21 | r04 | Manchester UnitedManchester Un | 4 - 1 | NewcastleNewcastle |
| 11 Sep 21 | r04 | SouthamptonSouthampton | 0 - 0 | West HamWest Ham |
| 11 Sep 21 | r04 | WatfordWatford | 0 - 2 | WolvesWolves |
| 11 Sep 21 | r04 | ChelseaChelsea | 3 - 0 | Aston VillaAston Villa |
| 12 Sep 21 | r04 | LeedsLeeds | 0 - 3 | LiverpoolLiverpool |
| 13 Sep 21 | r04 | EvertonEverton | 3 - 1 | BurnleyBurnley |
| |
| 17 Sep 21 | r05 | NewcastleNewcastle | 1 - 1 | LeedsLeeds |
| 18 Sep 21 | r05 | WolvesWolves | 0 - 2 | BrentfordBrentford |
| 18 Sep 21 | r05 | BurnleyBurnley | 0 - 1 | ArsenalArsenal |
| 18 Sep 21 | r05 | LiverpoolLiverpool | 3 - 0 | Crystal PalaceCrystal Palac |
| 18 Sep 21 | r05 | Manchester CityManchester Ci | 0 - 0 | SouthamptonSouthampton |
| 18 Sep 21 | r05 | NorwichNorwich | 1 - 3 | WatfordWatford |
| 18 Sep 21 | r05 | Aston VillaAston Villa | 3 - 0 | EvertonEverton |
| 19 Sep 21 | r05 | BrightonBrighton | 2 - 1 | LeicesterLeicester |
| 19 Sep 21 | r05 | West HamWest Ham | 1 - 2 | Manchester UnitedManchester Un |
| 19 Sep 21 | r05 | TottenhamTottenham | 0 - 3 | ChelseaChelsea |
| |
| 25 Sep 21 | r06  | ChelseaChelsea | 0 - 1 | Manchester CityManchester Ci |
| 25 Sep 21 | r06 | Manchester UnitedManchester Un | 0 - 1 | Aston VillaAston Villa |
| 25 Sep 21 | r06 | EvertonEverton | 2 - 0 | NorwichNorwich |
| 25 Sep 21 | r06 | LeedsLeeds | 1 - 2 | West HamWest Ham |
| 25 Sep 21 | r06 | LeicesterLeicester | 2 - 2 | BurnleyBurnley |
| 25 Sep 21 | r06 | WatfordWatford | 1 - 1 | NewcastleNewcastle |
| 25 Sep 21 | r06 | BrentfordBrentford | 3 - 3 | LiverpoolLiverpool |
| 26 Sep 21 | r06 | SouthamptonSouthampton | 0 - 1 | WolvesWolves |
| 26 Sep 21 | r06 | ArsenalArsenal | 3 - 1 | TottenhamTottenham |
| 27 Sep 21 | r06 | Crystal PalaceCrystal Palac | 1 - 1 | BrightonBrighton |
| |
| 02 Oct 21 | r07 | Manchester UnitedManchester Un | 1 - 1 | EvertonEverton |
| 02 Oct 21 | r07 | BurnleyBurnley | 0 - 0 | NorwichNorwich |
| 02 Oct 21 | r07 | ChelseaChelsea | 3 - 1 | SouthamptonSouthampton |
| 02 Oct 21 | r07 | LeedsLeeds | 1 - 0 | WatfordWatford |
| 02 Oct 21 | r07 | WolvesWolves | 2 - 1 | NewcastleNewcastle |
| 02 Oct 21 | r07 | BrightonBrighton | 0 - 0 | ArsenalArsenal |
| 03 Oct 21 | r07 | Crystal PalaceCrystal Palac | 2 - 2 | LeicesterLeicester |
| 03 Oct 21 | r07 | TottenhamTottenham | 2 - 1 | Aston VillaAston Villa |
| 03 Oct 21 | r07 | West HamWest Ham | 1 - 2 | BrentfordBrentford |
| 03 Oct 21 | r07 | LiverpoolLiverpool | 2 - 2 | Manchester CityManchester Ci |
| |
| 16 Oct 21 | r08 | WatfordWatford | 0 - 5 | LiverpoolLiverpool |
| 16 Oct 21 | r08 | Aston VillaAston Villa | 2 - 3 | WolvesWolves |
| 16 Oct 21 | r08 | LeicesterLeicester | 4 - 2 | Manchester UnitedManchester Un |
| 16 Oct 21 | r08 | Manchester CityManchester Ci | 2 - 0 | BurnleyBurnley |
| 16 Oct 21 | r08 | NorwichNorwich | 0 - 0 | BrightonBrighton |
| 16 Oct 21 | r08 | SouthamptonSouthampton | 1 - 0 | LeedsLeeds |
| 16 Oct 21 | r08 | BrentfordBrentford | 0 - 1 | ChelseaChelsea |
| 17 Oct 21 | r08 | EvertonEverton | 0 - 1 | West HamWest Ham |
| 17 Oct 21 | r08 | NewcastleNewcastle | 2 - 3 | TottenhamTottenham |
| 18 Oct 21 | r08 | ArsenalArsenal | 2 - 2 | Crystal PalaceCrystal Palac |
| |
| 22 Oct 21 | r09 | ArsenalArsenal | 3 - 1 | Aston VillaAston Villa |
| 23 Oct 21 | r09 | ChelseaChelsea | 7 - 0 | NorwichNorwich |
| 23 Oct 21 | r09 | Crystal PalaceCrystal Palac | 1 - 1 | NewcastleNewcastle |
| 23 Oct 21 | r09 | EvertonEverton | 2 - 5 | WatfordWatford |
| 23 Oct 21 | r09 | LeedsLeeds | 1 - 1 | WolvesWolves |
| 23 Oct 21 | r09 | SouthamptonSouthampton | 2 - 2 | BurnleyBurnley |
| 23 Oct 21 | r09 | BrightonBrighton | 1 - 4 | Manchester CityManchester Ci |
| 24 Oct 21 | r09 | BrentfordBrentford | 1 - 2 | LeicesterLeicester |
| 24 Oct 21 | r09 | West HamWest Ham | 1 - 0 | TottenhamTottenham |
| 24 Oct 21 | r09 | Manchester UnitedManchester Un | 0 - 5 | LiverpoolLiverpool |
| |
| 30 Oct 21 | r10 | LeicesterLeicester | 0 - 2 | ArsenalArsenal |
| 30 Oct 21 | r10 | BurnleyBurnley | 3 - 1 | BrentfordBrentford |
| 30 Oct 21 | r10 | LiverpoolLiverpool | 2 - 2 | BrightonBrighton |
| 30 Oct 21 | r10 | Manchester CityManchester Ci | 0 - 2 | Crystal PalaceCrystal Palac |
| 30 Oct 21 | r10 | NewcastleNewcastle | 0 - 3 | ChelseaChelsea |
| 30 Oct 21 | r10 | WatfordWatford | 0 - 1 | SouthamptonSouthampton |
| 30 Oct 21 | r10 | TottenhamTottenham | 0 - 3 | Manchester UnitedManchester Un |
| 31 Oct 21 | r10 | NorwichNorwich | 1 - 2 | LeedsLeeds |
| 31 Oct 21 | r10 | Aston VillaAston Villa | 1 - 4 | West HamWest Ham |
| 01 Nov 21 | r10 | WolvesWolves | 2 - 1 | EvertonEverton |
| |
| 05 Nov 21 | r11 | SouthamptonSouthampton | 1 - 0 | Aston VillaAston Villa |
| 06 Nov 21 | r11 | Manchester UnitedManchester Un | 0 - 2 | Manchester CityManchester Ci |
| 06 Nov 21 | r11 | BrentfordBrentford | 1 - 2 | NorwichNorwich |
| 06 Nov 21 | r11 | ChelseaChelsea | 1 - 1 | BurnleyBurnley |
| 06 Nov 21 | r11 | Crystal PalaceCrystal Palac | 2 - 0 | WolvesWolves |
| 06 Nov 21 | r11 | BrightonBrighton | 1 - 1 | NewcastleNewcastle |
| 07 Nov 21 | r11 | ArsenalArsenal | 1 - 0 | WatfordWatford |
| 07 Nov 21 | r11 | EvertonEverton | 0 - 0 | TottenhamTottenham |
| 07 Nov 21 | r11 | LeedsLeeds | 1 - 1 | LeicesterLeicester |
| 07 Nov 21 | r11 | West HamWest Ham | 3 - 2 | LiverpoolLiverpool |
| |
| 20 Nov 21 | r12 | LeicesterLeicester | 0 - 3 | ChelseaChelsea |
| 20 Nov 21 | r12 | Aston VillaAston Villa | 2 - 0 | BrightonBrighton |
| 20 Nov 21 | r12 | BurnleyBurnley | 3 - 3 | Crystal PalaceCrystal Palac |
| 20 Nov 21 | r12 | NewcastleNewcastle | 3 - 3 | BrentfordBrentford |
| 20 Nov 21 | r12 | NorwichNorwich | 2 - 1 | SouthamptonSouthampton |
| 20 Nov 21 | r12 | WatfordWatford | 4 - 1 | Manchester UnitedManchester Un |
| 20 Nov 21 | r12 | WolvesWolves | 1 - 0 | West HamWest Ham |
| 20 Nov 21 | r12 | LiverpoolLiverpool | 4 - 0 | ArsenalArsenal |
| 21 Nov 21 | r12 | Manchester CityManchester Ci | 3 - 0 | EvertonEverton |
| 21 Nov 21 | r12 | TottenhamTottenham | 2 - 1 | LeedsLeeds |
| |
| 27 Nov 21 | r13 | ArsenalArsenal | 2 - 0 | NewcastleNewcastle |
| 27 Nov 21 | r13 | Crystal PalaceCrystal Palac | 1 - 2 | Aston VillaAston Villa |
| 27 Nov 21 | r13 | LiverpoolLiverpool | 4 - 0 | SouthamptonSouthampton |
| 27 Nov 21 | r13 | NorwichNorwich | 0 - 0 | WolvesWolves |
| 27 Nov 21 | r13 | BrightonBrighton | 0 - 0 | LeedsLeeds |
| 28 Nov 21 | r13 | BrentfordBrentford | 1 - 0 | EvertonEverton |
| 28 Nov 21 | r13 | LeicesterLeicester | 4 - 2 | WatfordWatford |
| 28 Nov 21 | r13 | Manchester CityManchester Ci | 2 - 1 | West HamWest Ham |
| 28 Nov 21 | r13 | ChelseaChelsea | 1 - 1 | Manchester UnitedManchester Un |
| |
| 30 Nov 21 | r14 | NewcastleNewcastle | 1 - 1 | NorwichNorwich |
| 30 Nov 21 | r14 | LeedsLeeds | 1 - 0 | Crystal PalaceCrystal Palac |
| 01 Dec 21 | r14 | WatfordWatford | 1 - 2 | ChelseaChelsea |
| 01 Dec 21 | r14 | West HamWest Ham | 1 - 1 | BrightonBrighton |
| 01 Dec 21 | r14 | WolvesWolves | 0 - 0 | BurnleyBurnley |
| 01 Dec 21 | r14 | SouthamptonSouthampton | 2 - 2 | LeicesterLeicester |
| 01 Dec 21 | r14 | Aston VillaAston Villa | 1 - 2 | Manchester CityManchester Ci |
| 01 Dec 21 | r14 | EvertonEverton | 1 - 4 | LiverpoolLiverpool |
| 02 Dec 21 | r14 | TottenhamTottenham | 2 - 0 | BrentfordBrentford |
| 02 Dec 21 | r14 | Manchester UnitedManchester Un | 3 - 2 | ArsenalArsenal |
| |
| 04 Dec 21 | r15 | West HamWest Ham | 3 - 2 | ChelseaChelsea |
| 04 Dec 21 | r15 | NewcastleNewcastle | 1 - 0 | BurnleyBurnley |
| 04 Dec 21 | r15 | SouthamptonSouthampton | 1 - 1 | BrightonBrighton |
| 04 Dec 21 | r15 | WolvesWolves | 0 - 1 | LiverpoolLiverpool |
| 04 Dec 21 | r15 | WatfordWatford | 1 - 3 | Manchester CityManchester Ci |
| 05 Dec 21 | r15 | LeedsLeeds | 2 - 2 | BrentfordBrentford |
| 05 Dec 21 | r15 | Manchester UnitedManchester Un | 1 - 0 | Crystal PalaceCrystal Palac |
| 05 Dec 21 | r15 | TottenhamTottenham | 3 - 0 | NorwichNorwich |
| 05 Dec 21 | r15 | Aston VillaAston Villa | 2 - 1 | LeicesterLeicester |
| 06 Dec 21 | r15 | EvertonEverton | 2 - 1 | ArsenalArsenal |
| |
| 10 Dec 21 | r16 | BrentfordBrentford | 2 - 1 | WatfordWatford |
| 11 Dec 21 | r16 | Manchester CityManchester Ci | 1 - 0 | WolvesWolves |
| 11 Dec 21 | r16 | ArsenalArsenal | 3 - 0 | SouthamptonSouthampton |
| 11 Dec 21 | r16 | ChelseaChelsea | 3 - 2 | LeedsLeeds |
| 11 Dec 21 | r16 | LiverpoolLiverpool | 1 - 0 | Aston VillaAston Villa |
| 11 Dec 21 | r16 | NorwichNorwich | 0 - 1 | Manchester UnitedManchester Un |
| 12 Dec 21 | r16 | BurnleyBurnley | 0 - 0 | West HamWest Ham |
| 12 Dec 21 | r16 | LeicesterLeicester | 4 - 0 | NewcastleNewcastle |
| 12 Dec 21 | r16 | Crystal PalaceCrystal Palac | 3 - 1 | EvertonEverton |
| |
| 14 Dec 21 | r17 | NorwichNorwich | 0 - 2 | Aston VillaAston Villa |
| 14 Dec 21 | r17 | Manchester CityManchester Ci | 7 - 0 | LeedsLeeds |
| 15 Dec 21 | r17 | BrightonBrighton | 0 - 1 | WolvesWolves |
| 15 Dec 21 | r17 | Crystal PalaceCrystal Palac | 2 - 2 | SouthamptonSouthampton |
| 15 Dec 21 | r17 | ArsenalArsenal | 2 - 0 | West HamWest Ham |
| 16 Dec 21 | r17 | ChelseaChelsea | 1 - 1 | EvertonEverton |
| 16 Dec 21 | r17 | LiverpoolLiverpool | 3 - 1 | NewcastleNewcastle |
| |
| 18 Dec 21 | r18 | LeedsLeeds | 1 - 4 | ArsenalArsenal |
| 19 Dec 21 | r18 | NewcastleNewcastle | 0 - 4 | Manchester CityManchester Ci |
| 19 Dec 21 | r18 | WolvesWolves | 0 - 0 | ChelseaChelsea |
| 19 Dec 21 | r18 | TottenhamTottenham | 2 - 2 | LiverpoolLiverpool |
| |
| 26 Dec 21 | r19 | Manchester CityManchester Ci | 6 - 3 | LeicesterLeicester |
| 26 Dec 21 | r19 | NorwichNorwich | 0 - 5 | ArsenalArsenal |
| 26 Dec 21 | r19 | TottenhamTottenham | 3 - 0 | Crystal PalaceCrystal Palac |
| 26 Dec 21 | r19 | West HamWest Ham | 2 - 3 | SouthamptonSouthampton |
| 26 Dec 21 | r19 | Aston VillaAston Villa | 1 - 3 | ChelseaChelsea |
| 26 Dec 21 | r19 | BrightonBrighton | 2 - 0 | BrentfordBrentford |
| 27 Dec 21 | r19 | NewcastleNewcastle | 1 - 1 | Manchester UnitedManchester Un |
| |
| 28 Dec 21 | r20 | Crystal PalaceCrystal Palac | 3 - 0 | NorwichNorwich |
| 28 Dec 21 | r20 | SouthamptonSouthampton | 1 - 1 | TottenhamTottenham |
| 28 Dec 21 | r20 | WatfordWatford | 1 - 4 | West HamWest Ham |
| 28 Dec 21 | r20 | LeicesterLeicester | 1 - 0 | LiverpoolLiverpool |
| 29 Dec 21 | r20 | ChelseaChelsea | 1 - 1 | BrightonBrighton |
| 29 Dec 21 | r20 | BrentfordBrentford | 0 - 1 | Manchester CityManchester Ci |
| 30 Dec 21 | r20 | Manchester UnitedManchester Un | 3 - 1 | BurnleyBurnley |
| |
| 01 Jan 22 | r21 | ArsenalArsenal | 1 - 2 | Manchester CityManchester Ci |
| 01 Jan 22 | r21 | WatfordWatford | 0 - 1 | TottenhamTottenham |
| 01 Jan 22 | r21 | Crystal PalaceCrystal Palac | 2 - 3 | West HamWest Ham |
| 02 Jan 22 | r21 | BrentfordBrentford | 2 - 1 | Aston VillaAston Villa |
| 02 Jan 22 | r21 | EvertonEverton | 2 - 3 | BrightonBrighton |
| 02 Jan 22 | r21 | LeedsLeeds | 3 - 1 | BurnleyBurnley |
| 02 Jan 22 | r21 | ChelseaChelsea | 2 - 2 | LiverpoolLiverpool |
| 03 Jan 22 | r21 | Manchester UnitedManchester Un | 0 - 1 | WolvesWolves |
| |
| 11 Jan 22 | r18 | SouthamptonSouthampton | 4 - 1 | BrentfordBrentford |
| 12 Jan 22 | r18 | West HamWest Ham | 2 - 0 | NorwichNorwich |
| |
| 14 Jan 22 | r22 | BrightonBrighton | 1 - 1 | Crystal PalaceCrystal Palac |
| 15 Jan 22 | r22 | Manchester CityManchester Ci | 1 - 0 | ChelseaChelsea |
| 15 Jan 22 | r22 | NewcastleNewcastle | 1 - 1 | WatfordWatford |
| 15 Jan 22 | r22 | NorwichNorwich | 2 - 1 | EvertonEverton |
| 15 Jan 22 | r22 | WolvesWolves | 3 - 1 | SouthamptonSouthampton |
| 15 Jan 22 | r22 | Aston VillaAston Villa | 2 - 2 | Manchester UnitedManchester Un |
| 16 Jan 22 | r22 | LiverpoolLiverpool | 3 - 0 | BrentfordBrentford |
| 16 Jan 22 | r22 | West HamWest Ham | 2 - 3 | LeedsLeeds |
| |
| 18 Jan 22 | r24 | BrightonBrighton | 1 - 1 | ChelseaChelsea |
| |
| 19 Jan 22 | r17 | LeicesterLeicester | 2 - 3 | TottenhamTottenham |
| 19 Jan 22 | r17 | BrentfordBrentford | 1 - 3 | Manchester UnitedManchester Un |
| |
| 21 Jan 22 | r23 | WatfordWatford | 0 - 3 | NorwichNorwich |
| 22 Jan 22 | r23 | EvertonEverton | 0 - 1 | Aston VillaAston Villa |
| 22 Jan 22 | r23 | BrentfordBrentford | 1 - 2 | WolvesWolves |
| 22 Jan 22 | r23 | LeedsLeeds | 0 - 1 | NewcastleNewcastle |
| 22 Jan 22 | r23 | Manchester UnitedManchester Un | 1 - 0 | West HamWest Ham |
| 22 Jan 22 | r23 | SouthamptonSouthampton | 1 - 1 | Manchester CityManchester Ci |
| 23 Jan 22 | r23 | ArsenalArsenal | 0 - 0 | BurnleyBurnley |
| 23 Jan 22 | r23 | Crystal PalaceCrystal Palac | 1 - 3 | LiverpoolLiverpool |
| 23 Jan 22 | r23 | LeicesterLeicester | 1 - 1 | BrightonBrighton |
| 23 Jan 22 | r23 | ChelseaChelsea | 2 - 0 | TottenhamTottenham |
| |
| 05 Feb 22 | r17 | BurnleyBurnley | 0 - 0 | WatfordWatford |
| |
| 08 Feb 22 | r24 | West HamWest Ham | 1 - 0 | WatfordWatford |
| 08 Feb 22 | r24 | NewcastleNewcastle | 3 - 1 | EvertonEverton |
| 08 Feb 22 | r24 | BurnleyBurnley | 1 - 1 | Manchester UnitedManchester Un |
| 09 Feb 22 | r24 | NorwichNorwich | 1 - 1 | Crystal PalaceCrystal Palac |
| 09 Feb 22 | r24 | TottenhamTottenham | 2 - 3 | SouthamptonSouthampton |
| 09 Feb 22 | r24 | Manchester CityManchester Ci | 2 - 0 | BrentfordBrentford |
| 09 Feb 22 | r24 | Aston VillaAston Villa | 3 - 3 | LeedsLeeds |
| 10 Feb 22 | r24 | WolvesWolves | 0 - 1 | ArsenalArsenal |
| 10 Feb 22 | r24 | LiverpoolLiverpool | 2 - 0 | LeicesterLeicester |
| |
| 12 Feb 22 | r25 | Manchester UnitedManchester Un | 1 - 1 | SouthamptonSouthampton |
| 12 Feb 22 | r25 | BrentfordBrentford | 0 - 0 | Crystal PalaceCrystal Palac |
| 12 Feb 22 | r25 | EvertonEverton | 3 - 0 | LeedsLeeds |
| 12 Feb 22 | r25 | WatfordWatford | 0 - 2 | BrightonBrighton |
| 12 Feb 22 | r25 | NorwichNorwich | 0 - 4 | Manchester CityManchester Ci |
| 13 Feb 22 | r25 | BurnleyBurnley | 0 - 1 | LiverpoolLiverpool |
| 13 Feb 22 | r25 | NewcastleNewcastle | 1 - 0 | Aston VillaAston Villa |
| 13 Feb 22 | r25 | TottenhamTottenham | 0 - 2 | WolvesWolves |
| 13 Feb 22 | r25 | LeicesterLeicester | 2 - 2 | West HamWest Ham |
| |
| 15 Feb 22 | r18 | Manchester UnitedManchester Un | 2 - 0 | BrightonBrighton |
| |
| 19 Feb 22 | r26 | West HamWest Ham | 1 - 1 | NewcastleNewcastle |
| 19 Feb 22 | r26 | ArsenalArsenal | 2 - 1 | BrentfordBrentford |
| 19 Feb 22 | r26 | Aston VillaAston Villa | 0 - 1 | WatfordWatford |
| 19 Feb 22 | r26 | BrightonBrighton | 0 - 3 | BurnleyBurnley |
| 19 Feb 22 | r26 | Crystal PalaceCrystal Palac | 0 - 1 | ChelseaChelsea |
| 19 Feb 22 | r26 | LiverpoolLiverpool | 3 - 1 | NorwichNorwich |
| 19 Feb 22 | r26 | SouthamptonSouthampton | 2 - 0 | EvertonEverton |
| 19 Feb 22 | r26 | Manchester CityManchester Ci | 2 - 3 | TottenhamTottenham |
| 20 Feb 22 | r26 | LeedsLeeds | 2 - 4 | Manchester UnitedManchester Un |
| 20 Feb 22 | r26 | WolvesWolves | 2 - 1 | LeicesterLeicester |
| |
| 23 Feb 22 | r13 | BurnleyBurnley | 1 - 0 | TottenhamTottenham |
| |
| 23 Feb 22 | r18 | WatfordWatford | 1 - 4 | Crystal PalaceCrystal Palac |
| |
| 23 Feb 22 | r19 | LiverpoolLiverpool | 6 - 0 | LeedsLeeds |
| |
| 24 Feb 22 | r20 | ArsenalArsenal | 2 - 1 | WolvesWolves |
| |
| 25 Feb 22 | r27 | SouthamptonSouthampton | 2 - 0 | NorwichNorwich |
| 26 Feb 22 | r27 | LeedsLeeds | 0 - 4 | TottenhamTottenham |
| 26 Feb 22 | r27 | BrentfordBrentford | 0 - 2 | NewcastleNewcastle |
| 26 Feb 22 | r27 | Crystal PalaceCrystal Palac | 1 - 1 | BurnleyBurnley |
| 26 Feb 22 | r27 | Manchester UnitedManchester Un | 0 - 0 | WatfordWatford |
| 26 Feb 22 | r27 | BrightonBrighton | 0 - 2 | Aston VillaAston Villa |
| 26 Feb 22 | r27 | EvertonEverton | 0 - 1 | Manchester CityManchester Ci |
| 27 Feb 22 | r27 | West HamWest Ham | 1 - 0 | WolvesWolves |
| |
| 01 Mar 22 | r22 | BurnleyBurnley | 0 - 2 | LeicesterLeicester |
| |
| 05 Mar 22 | r28 | LeicesterLeicester | 1 - 0 | LeedsLeeds |
| 05 Mar 22 | r28 | Aston VillaAston Villa | 4 - 0 | SouthamptonSouthampton |
| 05 Mar 22 | r28 | BurnleyBurnley | 0 - 4 | ChelseaChelsea |
| 05 Mar 22 | r28 | NewcastleNewcastle | 2 - 1 | BrightonBrighton |
| 05 Mar 22 | r28 | NorwichNorwich | 1 - 3 | BrentfordBrentford |
| 05 Mar 22 | r28 | WolvesWolves | 0 - 2 | Crystal PalaceCrystal Palac |
| 05 Mar 22 | r28  | LiverpoolLiverpool | 1 - 0 | West HamWest Ham |
| 06 Mar 22 | r28 | WatfordWatford | 2 - 3 | ArsenalArsenal |
| 06 Mar 22 | r28 | Manchester CityManchester Ci | 4 - 1 | Manchester UnitedManchester Un |
| 07 Mar 22 | r28 | TottenhamTottenham | 5 - 0 | EvertonEverton |
| |
| 10 Mar 22 | r19 | WolvesWolves | 4 - 0 | WatfordWatford |
| |
| 10 Mar 22 | r21 | SouthamptonSouthampton | 1 - 2 | NewcastleNewcastle |
| |
| 10 Mar 22 | r30 | NorwichNorwich | 1 - 3 | ChelseaChelsea |
| |
| 10 Mar 22 | r20 | LeedsLeeds | 0 - 3 | Aston VillaAston Villa |
| |
| 12 Mar 22 | r29 | BrightonBrighton | 0 - 2 | LiverpoolLiverpool |
| 12 Mar 22 | r29 | BrentfordBrentford | 2 - 0 | BurnleyBurnley |
| 12 Mar 22 | r29 | Manchester UnitedManchester Un | 3 - 2 | TottenhamTottenham |
| 13 Mar 22 | r29 | ChelseaChelsea | 1 - 0 | NewcastleNewcastle |
| 13 Mar 22 | r29 | EvertonEverton | 0 - 1 | WolvesWolves |
| 13 Mar 22 | r29 | LeedsLeeds | 2 - 1 | NorwichNorwich |
| 13 Mar 22 | r29 | SouthamptonSouthampton | 1 - 2 | WatfordWatford |
| 13 Mar 22 | r29 | West HamWest Ham | 2 - 1 | Aston VillaAston Villa |
| 13 Mar 22 | r29 | ArsenalArsenal | 2 - 0 | LeicesterLeicester |
| 14 Mar 22 | r29 | Crystal PalaceCrystal Palac | 0 - 0 | Manchester CityManchester Ci |
| |
| 16 Mar 22 | r16 | BrightonBrighton | 0 - 2 | TottenhamTottenham |
| |
| 16 Mar 22 | r27 | ArsenalArsenal | 0 - 2 | LiverpoolLiverpool |
| |
| 17 Mar 22 | r20 | EvertonEverton | 1 - 0 | NewcastleNewcastle |
| |
| 18 Mar 22 | r30 | WolvesWolves | 2 - 3 | LeedsLeeds |
| 19 Mar 22 | r30 | Aston VillaAston Villa | 0 - 1 | ArsenalArsenal |
| 20 Mar 22 | r30 | LeicesterLeicester | 2 - 1 | BrentfordBrentford |
| 20 Mar 22 | r30 | TottenhamTottenham | 3 - 1 | West HamWest Ham |
| |
| 02 Apr 22 | r31 | LiverpoolLiverpool | 2 - 0 | WatfordWatford |
| 02 Apr 22 | r31 | BrightonBrighton | 0 - 0 | NorwichNorwich |
| 02 Apr 22 | r31 | BurnleyBurnley | 0 - 2 | Manchester CityManchester Ci |
| 02 Apr 22 | r31 | ChelseaChelsea | 1 - 4 | BrentfordBrentford |
| 02 Apr 22 | r31 | LeedsLeeds | 1 - 1 | SouthamptonSouthampton |
| 02 Apr 22 | r31 | WolvesWolves | 2 - 1 | Aston VillaAston Villa |
| 02 Apr 22 | r31 | Manchester UnitedManchester Un | 1 - 1 | LeicesterLeicester |
| 03 Apr 22 | r31 | West HamWest Ham | 2 - 1 | EvertonEverton |
| 03 Apr 22 | r31 | TottenhamTottenham | 5 - 1 | NewcastleNewcastle |
| 04 Apr 22 | r31 | Crystal PalaceCrystal Palac | 3 - 0 | ArsenalArsenal |
| |
| 06 Apr 22 | r19 | BurnleyBurnley | 3 - 2 | EvertonEverton |
| |
| 08 Apr 22 | r32 | NewcastleNewcastle | 1 - 0 | WolvesWolves |
| 09 Apr 22 | r32 | EvertonEverton | 1 - 0 | Manchester UnitedManchester Un |
| 09 Apr 22 | r32 | ArsenalArsenal | 1 - 2 | BrightonBrighton |
| 09 Apr 22 | r32 | SouthamptonSouthampton | 0 - 6 | ChelseaChelsea |
| 09 Apr 22 | r32 | WatfordWatford | 0 - 3 | LeedsLeeds |
| 09 Apr 22 | r32 | Aston VillaAston Villa | 0 - 4 | TottenhamTottenham |
| 10 Apr 22 | r32 | BrentfordBrentford | 2 - 0 | West HamWest Ham |
| 10 Apr 22 | r32 | LeicesterLeicester | 2 - 1 | Crystal PalaceCrystal Palac |
| 10 Apr 22 | r32 | NorwichNorwich | 2 - 0 | BurnleyBurnley |
| 10 Apr 22 | r32 | Manchester CityManchester Ci | 2 - 2 | LiverpoolLiverpool |
| |
| 16 Apr 22 | r33 | TottenhamTottenham | 0 - 1 | BrightonBrighton |
| 16 Apr 22 | r33 | Manchester UnitedManchester Un | 3 - 2 | NorwichNorwich |
| 16 Apr 22 | r33 | SouthamptonSouthampton | 1 - 0 | ArsenalArsenal |
| 16 Apr 22 | r33 | WatfordWatford | 1 - 2 | BrentfordBrentford |
| 17 Apr 22 | r33 | NewcastleNewcastle | 2 - 1 | LeicesterLeicester |
| 17 Apr 22 | r33 | West HamWest Ham | 1 - 1 | BurnleyBurnley |
| |
| 19 Apr 22 | r30 | LiverpoolLiverpool | 4 - 0 | Manchester UnitedManchester Un |
| |
| 20 Apr 22 | r18 | EvertonEverton | 1 - 1 | LeicesterLeicester |
| |
| 20 Apr 22 | r25 | ChelseaChelsea | 2 - 4 | ArsenalArsenal |
| |
| 20 Apr 22 | r30 | NewcastleNewcastle | 1 - 0 | Crystal PalaceCrystal Palac |
| 20 Apr 22 | r30 | Manchester CityManchester Ci | 3 - 0 | BrightonBrighton |
| 21 Apr 22 | r30 | BurnleyBurnley | 2 - 0 | SouthamptonSouthampton |
| |
| 23 Apr 22 | r34 | ArsenalArsenal | 3 - 1 | Manchester UnitedManchester Un |
| 23 Apr 22 | r34 | LeicesterLeicester | 0 - 0 | Aston VillaAston Villa |
| 23 Apr 22 | r34 | Manchester CityManchester Ci | 5 - 1 | WatfordWatford |
| 23 Apr 22 | r34 | NorwichNorwich | 0 - 3 | NewcastleNewcastle |
| 23 Apr 22 | r34 | BrentfordBrentford | 0 - 0 | TottenhamTottenham |
| 24 Apr 22 | r34 | BrightonBrighton | 2 - 2 | SouthamptonSouthampton |
| 24 Apr 22 | r34 | BurnleyBurnley | 1 - 0 | WolvesWolves |
| 24 Apr 22 | r34 | ChelseaChelsea | 1 - 0 | West HamWest Ham |
| 24 Apr 22 | r34 | LiverpoolLiverpool | 2 - 0 | EvertonEverton |
| 25 Apr 22 | r34 | Crystal PalaceCrystal Palac | 0 - 0 | LeedsLeeds |
| |
| 28 Apr 22 | r37 | Manchester UnitedManchester Un | 1 - 1 | ChelseaChelsea |
| |
| 30 Apr 22 | r35 | NewcastleNewcastle | 0 - 1 | LiverpoolLiverpool |
| 30 Apr 22 | r35 | Aston VillaAston Villa | 2 - 0 | NorwichNorwich |
| 30 Apr 22 | r35 | SouthamptonSouthampton | 1 - 2 | Crystal PalaceCrystal Palac |
| 30 Apr 22 | r35 | WatfordWatford | 1 - 2 | BurnleyBurnley |
| 30 Apr 22 | r35 | WolvesWolves | 0 - 3 | BrightonBrighton |
| 30 Apr 22 | r35 | LeedsLeeds | 0 - 4 | Manchester CityManchester Ci |
| 01 May 22 | r35 | EvertonEverton | 1 - 0 | ChelseaChelsea |
| 01 May 22 | r35 | TottenhamTottenham | 3 - 1 | LeicesterLeicester |
| 01 May 22 | r35 | West HamWest Ham | 1 - 2 | ArsenalArsenal |
| 02 May 22 | r35 | Manchester UnitedManchester Un | 3 - 0 | BrentfordBrentford |
| |
| 07 May 22 | r36 | BrentfordBrentford | 3 - 0 | SouthamptonSouthampton |
| 07 May 22 | r36 | BurnleyBurnley | 1 - 3 | Aston VillaAston Villa |
| 07 May 22 | r36 | ChelseaChelsea | 2 - 2 | WolvesWolves |
| 07 May 22 | r36 | Crystal PalaceCrystal Palac | 1 - 0 | WatfordWatford |
| 07 May 22 | r36 | BrightonBrighton | 4 - 0 | Manchester UnitedManchester Un |
| 07 May 22 | r36 | LiverpoolLiverpool | 1 - 1 | TottenhamTottenham |
| 08 May 22 | r36 | ArsenalArsenal | 2 - 1 | LeedsLeeds |
| 08 May 22 | r36 | LeicesterLeicester | 1 - 2 | EvertonEverton |
| 08 May 22 | r36 | NorwichNorwich | 0 - 4 | West HamWest Ham |
| 08 May 22 | r36 | Manchester CityManchester Ci | 5 - 0 | NewcastleNewcastle |
| |
| 10 May 22 | r33 | Aston VillaAston Villa | 1 - 2 | LiverpoolLiverpool |
| 11 May 22 | r33 | LeedsLeeds | 0 - 3 | ChelseaChelsea |
| |
| 11 May 22 | r21 | LeicesterLeicester | 3 - 0 | NorwichNorwich |
| |
| 11 May 22 | r30 | WatfordWatford | 0 - 0 | EvertonEverton |
| |
| 11 May 22 | r33 | WolvesWolves | 1 - 5 | Manchester CityManchester Ci |
| |
| 12 May 22 | r22 | TottenhamTottenham | 3 - 0 | ArsenalArsenal |
| |
| 15 May 22 | r37 | TottenhamTottenham | 1 - 0 | BurnleyBurnley |
| 15 May 22 | r37 | Aston VillaAston Villa | 1 - 1 | Crystal PalaceCrystal Palac |
| 15 May 22 | r37 | LeedsLeeds | 1 - 1 | BrightonBrighton |
| 15 May 22 | r37 | WatfordWatford | 1 - 5 | LeicesterLeicester |
| 15 May 22 | r37 | West HamWest Ham | 2 - 2 | Manchester CityManchester Ci |
| 15 May 22 | r37 | WolvesWolves | 1 - 1 | NorwichNorwich |
| 15 May 22 | r37 | EvertonEverton | 2 - 3 | BrentfordBrentford |
| 16 May 22 | r37 | NewcastleNewcastle | 2 - 0 | ArsenalArsenal |
| 17 May 22 | r37 | SouthamptonSouthampton | 1 - 2 | LiverpoolLiverpool |
| |
| 19 May 22 | r33 | EvertonEverton | 3 - 2 | Crystal PalaceCrystal Palac |
| |
| 19 May 22 | r18 | Aston VillaAston Villa | 1 - 1 | BurnleyBurnley |
| |
| 19 May 22 | r27 | ChelseaChelsea | 1 - 1 | LeicesterLeicester |
| |
| 22 May 22 | r38 | ArsenalArsenal | 5 - 1 | EvertonEverton |
| 22 May 22 | r38 | BrentfordBrentford | 1 - 2 | LeedsLeeds |
| 22 May 22 | r38 | BrightonBrighton | 3 - 1 | West HamWest Ham |
| 22 May 22 | r38 | BurnleyBurnley | 1 - 2 | NewcastleNewcastle |
| 22 May 22 | r38 | ChelseaChelsea | 2 - 1 | WatfordWatford |
| 22 May 22 | r38 | Crystal PalaceCrystal Palac | 1 - 0 | Manchester UnitedManchester Un |
| 22 May 22 | r38 | LeicesterLeicester | 4 - 1 | SouthamptonSouthampton |
| 22 May 22 | r38 | LiverpoolLiverpool | 3 - 1 | WolvesWolves |
| 22 May 22 | r38 | Manchester CityManchester Ci | 3 - 2 | Aston VillaAston Villa |
| 22 May 22 | r38 | NorwichNorwich | 0 - 5 | TottenhamTottenham |
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