| 12 Sep 20 | r01        | Crystal PalaceCrystal Palac | 1 - 0 | SouthamptonSouthampton |
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| 19 Sep 20 | r02        | Manchester UnitedManchester Un | 1 - 3 | Crystal PalaceCrystal Palac |
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| 26 Sep 20 | r03        | Crystal PalaceCrystal Palac | 1 - 2 | EvertonEverton |
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| 03 Oct 20 | r04        | ChelseaChelsea | 4 - 0 | Crystal PalaceCrystal Palac |
| |
| 18 Oct 20 | r05        | Crystal PalaceCrystal Palac | 1 - 1 | BrightonBrighton |
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| 24 Oct 20 | r06        | FulhamFulham | 1 - 2 | Crystal PalaceCrystal Palac |
| |
| 30 Oct 20 | r07        | WolvesWolves | 2 - 0 | Crystal PalaceCrystal Palac |
| |
| 07 Nov 20 | r08        | Crystal PalaceCrystal Palac | 4 - 1 | LeedsLeeds |
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| 23 Nov 20 | r09        | BurnleyBurnley | 1 - 0 | Crystal PalaceCrystal Palac |
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| 27 Nov 20 | r10        | Crystal PalaceCrystal Palac | 0 - 2 | NewcastleNewcastle |
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| 06 Dec 20 | r11        | West BromWest Brom | 1 - 5 | Crystal PalaceCrystal Palac |
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| 13 Dec 20 | r12        | Crystal PalaceCrystal Palac | 1 - 1 | TottenhamTottenham |
| |
| 16 Dec 20 | r13        | West HamWest Ham | 1 - 1 | Crystal PalaceCrystal Palac |
| |
| 19 Dec 20 | r14        | Crystal PalaceCrystal Palac | 0 - 7 | LiverpoolLiverpool |
| |
| 26 Dec 20 | r15        | Aston VillaAston Villa | 3 - 0 | Crystal PalaceCrystal Palac |
| |
| 28 Dec 20 | r16        | Crystal PalaceCrystal Palac | 1 - 1 | LeicesterLeicester |
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| 02 Jan 21 | r17        | Crystal PalaceCrystal Palac | 2 - 0 | Sheffield UnitedSheffield Uni |
| |
| 14 Jan 21 | r18        | ArsenalArsenal | 0 - 0 | Crystal PalaceCrystal Palac |
| |
| 17 Jan 21 | r19        | Manchester CityManchester Ci | 4 - 0 | Crystal PalaceCrystal Palac |
| |
| 26 Jan 21 | r20        | Crystal PalaceCrystal Palac | 2 - 3 | West HamWest Ham |
| |
| 30 Jan 21 | r21        | Crystal PalaceCrystal Palac | 1 - 0 | WolvesWolves |
| |
| 02 Feb 21 | r22        | NewcastleNewcastle | 1 - 2 | Crystal PalaceCrystal Palac |
| |
| 08 Feb 21 | r23        | LeedsLeeds | 2 - 0 | Crystal PalaceCrystal Palac |
| |
| 13 Feb 21 | r24        | Crystal PalaceCrystal Palac | 0 - 3 | BurnleyBurnley |
| |
| 22 Feb 21 | r25        | BrightonBrighton | 1 - 2 | Crystal PalaceCrystal Palac |
| |
| 28 Feb 21 | r26        | Crystal PalaceCrystal Palac | 0 - 0 | FulhamFulham |
| |
| 03 Mar 21 | r29        | Crystal PalaceCrystal Palac | 0 - 0 | Manchester UnitedManchester Un |
| |
| 07 Mar 21 | r27        | TottenhamTottenham | 4 - 1 | Crystal PalaceCrystal Palac |
| |
| 13 Mar 21 | r28        | Crystal PalaceCrystal Palac | 1 - 0 | West BromWest Brom |
| |
| 05 Apr 21 | r30        | EvertonEverton | 1 - 1 | Crystal PalaceCrystal Palac |
| |
| 10 Apr 21 | r31        | Crystal PalaceCrystal Palac | 1 - 4 | ChelseaChelsea |
| |
| 26 Apr 21 | r33        | LeicesterLeicester | 2 - 1 | Crystal PalaceCrystal Palac |
| |
| 01 May 21 | r34        | Crystal PalaceCrystal Palac | 0 - 2 | Manchester CityManchester Ci |
| |
| 08 May 21 | r35        | Sheffield UnitedSheffield Uni | 0 - 2 | Crystal PalaceCrystal Palac |
| |
| 11 May 21 | r32        | SouthamptonSouthampton | 3 - 1 | Crystal PalaceCrystal Palac |
| |
| 16 May 21 | r36        | Crystal PalaceCrystal Palac | 3 - 2 | Aston VillaAston Villa |
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| 19 May 21 | r37        | Crystal PalaceCrystal Palac | 1 - 3 | ArsenalArsenal |
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| 23 May 21 | r38        | LiverpoolLiverpool | 2 - 0 | Crystal PalaceCrystal Palac |