| 21 Sep 20 | r02        | WolvesWolves | 1 - 3 | Manchester CityManchester Ci |
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| 27 Sep 20 | r03        | Manchester CityManchester Ci | 2 - 5 | LeicesterLeicester |
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| 03 Oct 20 | r04        | LeedsLeeds | 1 - 1 | Manchester CityManchester Ci |
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| 17 Oct 20 | r05        | Manchester CityManchester Ci | 1 - 0 | ArsenalArsenal |
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| 24 Oct 20 | r06        | West HamWest Ham | 1 - 1 | Manchester CityManchester Ci |
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| 31 Oct 20 | r07        | Sheffield UnitedSheffield Uni | 0 - 1 | Manchester CityManchester Ci |
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| 08 Nov 20 | r08        | Manchester CityManchester Ci | 1 - 1 | LiverpoolLiverpool |
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| 21 Nov 20 | r09        | TottenhamTottenham | 2 - 0 | Manchester CityManchester Ci |
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| 28 Nov 20 | r10        | Manchester CityManchester Ci | 5 - 0 | BurnleyBurnley |
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| 05 Dec 20 | r11        | Manchester CityManchester Ci | 2 - 0 | FulhamFulham |
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| 12 Dec 20 | r12        | Manchester UnitedManchester Un | 0 - 0 | Manchester CityManchester Ci |
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| 15 Dec 20 | r13        | Manchester CityManchester Ci | 1 - 1 | West BromWest Brom |
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| 19 Dec 20 | r14        | SouthamptonSouthampton | 0 - 1 | Manchester CityManchester Ci |
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| 26 Dec 20 | r15        | Manchester CityManchester Ci | 2 - 0 | NewcastleNewcastle |
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| 03 Jan 21 | r17        | ChelseaChelsea | 1 - 3 | Manchester CityManchester Ci |
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| 13 Jan 21 | r18        | Manchester CityManchester Ci | 1 - 0 | BrightonBrighton |
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| 17 Jan 21 | r19        | Manchester CityManchester Ci | 4 - 0 | Crystal PalaceCrystal Palac |
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| 20 Jan 21 | r01        | Manchester CityManchester Ci | 2 - 0 | Aston VillaAston Villa |
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| 26 Jan 21 | r20        | West BromWest Brom | 0 - 5 | Manchester CityManchester Ci |
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| 30 Jan 21 | r21        | Manchester CityManchester Ci | 1 - 0 | Sheffield UnitedSheffield Uni |
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| 03 Feb 21 | r22        | BurnleyBurnley | 0 - 2 | Manchester CityManchester Ci |
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| 07 Feb 21 | r23        | LiverpoolLiverpool | 1 - 4 | Manchester CityManchester Ci |
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| 13 Feb 21 | r24        | Manchester CityManchester Ci | 3 - 0 | TottenhamTottenham |
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| 17 Feb 21 | r16        | EvertonEverton | 1 - 3 | Manchester CityManchester Ci |
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| 21 Feb 21 | r25        | ArsenalArsenal | 0 - 1 | Manchester CityManchester Ci |
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| 27 Feb 21 | r26        | Manchester CityManchester Ci | 2 - 1 | West HamWest Ham |
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| 02 Mar 21 | r29        | Manchester CityManchester Ci | 4 - 1 | WolvesWolves |
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| 07 Mar 21 | r27        | Manchester CityManchester Ci | 0 - 2 | Manchester UnitedManchester Un |
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| 10 Mar 21 | r33        | Manchester CityManchester Ci | 5 - 2 | SouthamptonSouthampton |
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| 13 Mar 21 | r28        | FulhamFulham | 0 - 3 | Manchester CityManchester Ci |
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| 03 Apr 21 | r30        | LeicesterLeicester | 0 - 2 | Manchester CityManchester Ci |
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| 10 Apr 21 | r31        | Manchester CityManchester Ci | 1 - 2 | LeedsLeeds |
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| 21 Apr 21 | r32        | Aston VillaAston Villa | 1 - 2 | Manchester CityManchester Ci |
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| 01 May 21 | r34        | Crystal PalaceCrystal Palac | 0 - 2 | Manchester CityManchester Ci |
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| 08 May 21 | r35        | Manchester CityManchester Ci | 1 - 2 | ChelseaChelsea |
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| 14 May 21 | r36        | NewcastleNewcastle | 3 - 4 | Manchester CityManchester Ci |
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| 18 May 21 | r37        | BrightonBrighton | 3 - 2 | Manchester CityManchester Ci |
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| 23 May 21 | r38        | Manchester CityManchester Ci | 5 - 0 | EvertonEverton |