| 12 Sep 20 | r01      | FulhamFulham | 0 - 3 | ArsenalArsenal |
| 12 Sep 20 | r01 | Crystal PalaceCrystal Palac | 1 - 0 | SouthamptonSouthampton |
| 12 Sep 20 | r01 | LiverpoolLiverpool | 4 - 3 | LeedsLeeds |
| 12 Sep 20 | r01 | West HamWest Ham | 0 - 2 | NewcastleNewcastle |
| 13 Sep 20 | r01 | West BromWest Brom | 0 - 3 | LeicesterLeicester |
| 13 Sep 20 | r01 | TottenhamTottenham | 0 - 1 | EvertonEverton |
| 14 Sep 20 | r01 | Sheffield UnitedSheffield Uni | 0 - 2 | WolvesWolves |
| 14 Sep 20 | r01 | BrightonBrighton | 1 - 3 | ChelseaChelsea |
| |
| 19 Sep 20 | r02 | EvertonEverton | 5 - 2 | West BromWest Brom |
| 19 Sep 20 | r02 | LeedsLeeds | 4 - 3 | FulhamFulham |
| 19 Sep 20 | r02 | Manchester UnitedManchester Un | 1 - 3 | Crystal PalaceCrystal Palac |
| 19 Sep 20 | r02 | ArsenalArsenal | 2 - 1 | West HamWest Ham |
| 20 Sep 20 | r02 | SouthamptonSouthampton | 2 - 5 | TottenhamTottenham |
| 20 Sep 20 | r02 | NewcastleNewcastle | 0 - 3 | BrightonBrighton |
| 20 Sep 20 | r02 | ChelseaChelsea | 0 - 2 | LiverpoolLiverpool |
| 20 Sep 20 | r02 | LeicesterLeicester | 4 - 2 | BurnleyBurnley |
| 21 Sep 20 | r02 | Aston VillaAston Villa | 1 - 0 | Sheffield UnitedSheffield Uni |
| 21 Sep 20 | r02 | WolvesWolves | 1 - 3 | Manchester CityManchester Ci |
| |
| 26 Sep 20 | r03 | BrightonBrighton | 2 - 3 | Manchester UnitedManchester Un |
| 26 Sep 20 | r03 | Crystal PalaceCrystal Palac | 1 - 2 | EvertonEverton |
| 26 Sep 20 | r03 | West BromWest Brom | 3 - 3 | ChelseaChelsea |
| 26 Sep 20 | r03 | BurnleyBurnley | 0 - 1 | SouthamptonSouthampton |
| 27 Sep 20 | r03 | Sheffield UnitedSheffield Uni | 0 - 1 | LeedsLeeds |
| 27 Sep 20 | r03 | TottenhamTottenham | 1 - 1 | NewcastleNewcastle |
| 27 Sep 20 | r03 | Manchester CityManchester Ci | 2 - 5 | LeicesterLeicester |
| 27 Sep 20 | r03 | West HamWest Ham | 4 - 0 | WolvesWolves |
| 28 Sep 20 | r03 | FulhamFulham | 0 - 3 | Aston VillaAston Villa |
| 28 Sep 20 | r03 | LiverpoolLiverpool | 3 - 1 | ArsenalArsenal |
| |
| 03 Oct 20 | r04 | ChelseaChelsea | 4 - 0 | Crystal PalaceCrystal Palac |
| 03 Oct 20 | r04 | EvertonEverton | 4 - 2 | BrightonBrighton |
| 03 Oct 20 | r04 | LeedsLeeds | 1 - 1 | Manchester CityManchester Ci |
| 03 Oct 20 | r04 | NewcastleNewcastle | 3 - 1 | BurnleyBurnley |
| 04 Oct 20 | r04 | LeicesterLeicester | 0 - 3 | West HamWest Ham |
| 04 Oct 20 | r04 | SouthamptonSouthampton | 2 - 0 | West BromWest Brom |
| 04 Oct 20 | r04 | ArsenalArsenal | 2 - 1 | Sheffield UnitedSheffield Uni |
| 04 Oct 20 | r04 | WolvesWolves | 1 - 0 | FulhamFulham |
| 04 Oct 20 | r04 | Manchester UnitedManchester Un | 1 - 6 | TottenhamTottenham |
| 04 Oct 20 | r04  | Aston VillaAston Villa | 7 - 2 | LiverpoolLiverpool |
| |
| 17 Oct 20 | r05 | EvertonEverton | 2 - 2 | LiverpoolLiverpool |
| 17 Oct 20 | r05 | ChelseaChelsea | 3 - 3 | SouthamptonSouthampton |
| 17 Oct 20 | r05 | Manchester CityManchester Ci | 1 - 0 | ArsenalArsenal |
| 17 Oct 20 | r05 | NewcastleNewcastle | 1 - 4 | Manchester UnitedManchester Un |
| 18 Oct 20 | r05 | Sheffield UnitedSheffield Uni | 1 - 1 | FulhamFulham |
| 18 Oct 20 | r05 | Crystal PalaceCrystal Palac | 1 - 1 | BrightonBrighton |
| 18 Oct 20 | r05 | TottenhamTottenham | 3 - 3 | West HamWest Ham |
| 18 Oct 20 | r05 | LeicesterLeicester | 0 - 1 | Aston VillaAston Villa |
| 19 Oct 20 | r05 | West BromWest Brom | 0 - 0 | BurnleyBurnley |
| 19 Oct 20 | r05 | LeedsLeeds | 0 - 1 | WolvesWolves |
| |
| 23 Oct 20 | r06 | Aston VillaAston Villa | 0 - 3 | LeedsLeeds |
| 24 Oct 20 | r06 | West HamWest Ham | 1 - 1 | Manchester CityManchester Ci |
| 24 Oct 20 | r06 | FulhamFulham | 1 - 2 | Crystal PalaceCrystal Palac |
| 24 Oct 20 | r06 | Manchester UnitedManchester Un | 0 - 0 | ChelseaChelsea |
| 24 Oct 20 | r06 | LiverpoolLiverpool | 2 - 1 | Sheffield UnitedSheffield Uni |
| 25 Oct 20 | r06 | SouthamptonSouthampton | 2 - 0 | EvertonEverton |
| 25 Oct 20 | r06 | WolvesWolves | 1 - 1 | NewcastleNewcastle |
| 25 Oct 20 | r06 | ArsenalArsenal | 0 - 1 | LeicesterLeicester |
| 26 Oct 20 | r06 | BrightonBrighton | 1 - 1 | West BromWest Brom |
| 26 Oct 20 | r06 | BurnleyBurnley | 0 - 1 | TottenhamTottenham |
| |
| 30 Oct 20 | r07 | WolvesWolves | 2 - 0 | Crystal PalaceCrystal Palac |
| 31 Oct 20 | r07 | Sheffield UnitedSheffield Uni | 0 - 1 | Manchester CityManchester Ci |
| 31 Oct 20 | r07 | BurnleyBurnley | 0 - 3 | ChelseaChelsea |
| 31 Oct 20 | r07 | LiverpoolLiverpool | 2 - 1 | West HamWest Ham |
| 01 Nov 20 | r07 | Aston VillaAston Villa | 3 - 4 | SouthamptonSouthampton |
| 01 Nov 20 | r07 | NewcastleNewcastle | 2 - 1 | EvertonEverton |
| 01 Nov 20 | r07 | Manchester UnitedManchester Un | 0 - 1 | ArsenalArsenal |
| 01 Nov 20 | r07 | TottenhamTottenham | 2 - 1 | BrightonBrighton |
| 02 Nov 20 | r07 | FulhamFulham | 2 - 0 | West BromWest Brom |
| 02 Nov 20 | r07 | LeedsLeeds | 1 - 4 | LeicesterLeicester |
| |
| 06 Nov 20 | r08 | BrightonBrighton | 0 - 0 | BurnleyBurnley |
| 06 Nov 20 | r08 | SouthamptonSouthampton | 2 - 0 | NewcastleNewcastle |
| 07 Nov 20 | r08 | EvertonEverton | 1 - 3 | Manchester UnitedManchester Un |
| 07 Nov 20 | r08 | Crystal PalaceCrystal Palac | 4 - 1 | LeedsLeeds |
| 07 Nov 20 | r08 | ChelseaChelsea | 4 - 1 | Sheffield UnitedSheffield Uni |
| 07 Nov 20 | r08 | West HamWest Ham | 1 - 0 | FulhamFulham |
| 08 Nov 20 | r08 | West BromWest Brom | 0 - 1 | TottenhamTottenham |
| 08 Nov 20 | r08 | LeicesterLeicester | 1 - 0 | WolvesWolves |
| 08 Nov 20 | r08 | Manchester CityManchester Ci | 1 - 1 | LiverpoolLiverpool |
| 08 Nov 20 | r08 | ArsenalArsenal | 0 - 3 | Aston VillaAston Villa |
| |
| 21 Nov 20 | r09 | NewcastleNewcastle | 0 - 2 | ChelseaChelsea |
| 21 Nov 20 | r09 | Aston VillaAston Villa | 1 - 2 | BrightonBrighton |
| 21 Nov 20 | r09 | TottenhamTottenham | 2 - 0 | Manchester CityManchester Ci |
| 21 Nov 20 | r09 | Manchester UnitedManchester Un | 1 - 0 | West BromWest Brom |
| 22 Nov 20 | r09 | FulhamFulham | 2 - 3 | EvertonEverton |
| 22 Nov 20 | r09 | Sheffield UnitedSheffield Uni | 0 - 1 | West HamWest Ham |
| 22 Nov 20 | r09 | LeedsLeeds | 0 - 0 | ArsenalArsenal |
| 22 Nov 20 | r09 | LiverpoolLiverpool | 3 - 0 | LeicesterLeicester |
| 23 Nov 20 | r09 | BurnleyBurnley | 1 - 0 | Crystal PalaceCrystal Palac |
| 23 Nov 20 | r09 | WolvesWolves | 1 - 1 | SouthamptonSouthampton |
| |
| 27 Nov 20 | r10 | Crystal PalaceCrystal Palac | 0 - 2 | NewcastleNewcastle |
| 28 Nov 20 | r10 | BrightonBrighton | 1 - 1 | LiverpoolLiverpool |
| 28 Nov 20 | r10 | Manchester CityManchester Ci | 5 - 0 | BurnleyBurnley |
| 28 Nov 20 | r10 | EvertonEverton | 0 - 1 | LeedsLeeds |
| 28 Nov 20 | r10 | West BromWest Brom | 1 - 0 | Sheffield UnitedSheffield Uni |
| 29 Nov 20 | r10 | SouthamptonSouthampton | 2 - 3 | Manchester UnitedManchester Un |
| 29 Nov 20 | r10 | ChelseaChelsea | 0 - 0 | TottenhamTottenham |
| 29 Nov 20 | r10 | ArsenalArsenal | 1 - 2 | WolvesWolves |
| 30 Nov 20 | r10 | LeicesterLeicester | 1 - 2 | FulhamFulham |
| 30 Nov 20 | r10 | West HamWest Ham | 2 - 1 | Aston VillaAston Villa |
| |
| 05 Dec 20 | r11 | BurnleyBurnley | 1 - 1 | EvertonEverton |
| 05 Dec 20 | r11 | Manchester CityManchester Ci | 2 - 0 | FulhamFulham |
| 05 Dec 20 | r11 | West HamWest Ham | 1 - 3 | Manchester UnitedManchester Un |
| 05 Dec 20 | r11 | ChelseaChelsea | 3 - 1 | LeedsLeeds |
| 06 Dec 20 | r11 | West BromWest Brom | 1 - 5 | Crystal PalaceCrystal Palac |
| 06 Dec 20 | r11 | Sheffield UnitedSheffield Uni | 1 - 2 | LeicesterLeicester |
| 06 Dec 20 | r11 | TottenhamTottenham | 2 - 0 | ArsenalArsenal |
| 06 Dec 20 | r11 | LiverpoolLiverpool | 4 - 0 | WolvesWolves |
| 07 Dec 20 | r11 | BrightonBrighton | 1 - 2 | SouthamptonSouthampton |
| |
| 11 Dec 20 | r12 | LeedsLeeds | 1 - 2 | West HamWest Ham |
| 12 Dec 20 | r12 | WolvesWolves | 0 - 1 | Aston VillaAston Villa |
| 12 Dec 20 | r12 | NewcastleNewcastle | 2 - 1 | West BromWest Brom |
| 12 Dec 20 | r12 | Manchester UnitedManchester Un | 0 - 0 | Manchester CityManchester Ci |
| 12 Dec 20 | r12 | EvertonEverton | 1 - 0 | ChelseaChelsea |
| 13 Dec 20 | r12 | SouthamptonSouthampton | 3 - 0 | Sheffield UnitedSheffield Uni |
| 13 Dec 20 | r12 | Crystal PalaceCrystal Palac | 1 - 1 | TottenhamTottenham |
| 13 Dec 20 | r12 | FulhamFulham | 1 - 1 | LiverpoolLiverpool |
| 13 Dec 20 | r12 | LeicesterLeicester | 3 - 0 | BrightonBrighton |
| 13 Dec 20 | r12 | ArsenalArsenal | 0 - 1 | BurnleyBurnley |
| |
| 15 Dec 20 | r13 | WolvesWolves | 2 - 1 | ChelseaChelsea |
| 15 Dec 20 | r13 | Manchester CityManchester Ci | 1 - 1 | West BromWest Brom |
| 16 Dec 20 | r13 | ArsenalArsenal | 1 - 1 | SouthamptonSouthampton |
| 16 Dec 20 | r13 | LeedsLeeds | 5 - 2 | NewcastleNewcastle |
| 16 Dec 20 | r13 | LeicesterLeicester | 0 - 2 | EvertonEverton |
| 16 Dec 20 | r13 | FulhamFulham | 0 - 0 | BrightonBrighton |
| 16 Dec 20 | r13 | West HamWest Ham | 1 - 1 | Crystal PalaceCrystal Palac |
| 16 Dec 20 | r13 | LiverpoolLiverpool | 2 - 1 | TottenhamTottenham |
| 17 Dec 20 | r13 | Aston VillaAston Villa | 0 - 0 | BurnleyBurnley |
| 17 Dec 20 | r13 | Sheffield UnitedSheffield Uni | 2 - 3 | Manchester UnitedManchester Un |
| |
| 19 Dec 20 | r14 | Crystal PalaceCrystal Palac | 0 - 7 | LiverpoolLiverpool |
| 19 Dec 20 | r14 | SouthamptonSouthampton | 0 - 1 | Manchester CityManchester Ci |
| 19 Dec 20 | r14 | EvertonEverton | 2 - 1 | ArsenalArsenal |
| 19 Dec 20 | r14 | NewcastleNewcastle | 1 - 1 | FulhamFulham |
| 20 Dec 20 | r14 | BrightonBrighton | 1 - 1 | Sheffield UnitedSheffield Uni |
| 20 Dec 20 | r14 | TottenhamTottenham | 0 - 2 | LeicesterLeicester |
| 20 Dec 20 | r14 | Manchester UnitedManchester Un | 6 - 2 | LeedsLeeds |
| 20 Dec 20 | r14 | West BromWest Brom | 0 - 3 | Aston VillaAston Villa |
| 21 Dec 20 | r14 | BurnleyBurnley | 2 - 1 | WolvesWolves |
| 21 Dec 20 | r14 | ChelseaChelsea | 3 - 0 | West HamWest Ham |
| |
| 26 Dec 20 | r15 | LeicesterLeicester | 2 - 2 | Manchester UnitedManchester Un |
| 26 Dec 20 | r15 | Aston VillaAston Villa | 3 - 0 | Crystal PalaceCrystal Palac |
| 26 Dec 20 | r15 | FulhamFulham | 0 - 0 | SouthamptonSouthampton |
| 26 Dec 20 | r15 | ArsenalArsenal | 3 - 1 | ChelseaChelsea |
| 26 Dec 20 | r15 | Manchester CityManchester Ci | 2 - 0 | NewcastleNewcastle |
| 26 Dec 20 | r15 | Sheffield UnitedSheffield Uni | 0 - 1 | EvertonEverton |
| 27 Dec 20 | r15 | LeedsLeeds | 1 - 0 | BurnleyBurnley |
| 27 Dec 20 | r15 | West HamWest Ham | 2 - 2 | BrightonBrighton |
| 27 Dec 20 | r15 | LiverpoolLiverpool | 1 - 1 | West BromWest Brom |
| 27 Dec 20 | r15 | WolvesWolves | 1 - 1 | TottenhamTottenham |
| |
| 28 Dec 20 | r16 | Crystal PalaceCrystal Palac | 1 - 1 | LeicesterLeicester |
| 28 Dec 20 | r16 | ChelseaChelsea | 1 - 1 | Aston VillaAston Villa |
| 29 Dec 20 | r16 | BrightonBrighton | 0 - 1 | ArsenalArsenal |
| 29 Dec 20 | r16 | BurnleyBurnley | 1 - 0 | Sheffield UnitedSheffield Uni |
| 29 Dec 20 | r16 | SouthamptonSouthampton | 0 - 0 | West HamWest Ham |
| 29 Dec 20 | r16 | West BromWest Brom | 0 - 5 | LeedsLeeds |
| 29 Dec 20 | r16 | Manchester UnitedManchester Un | 1 - 0 | WolvesWolves |
| 30 Dec 20 | r16 | NewcastleNewcastle | 0 - 0 | LiverpoolLiverpool |
| |
| 01 Jan 21 | r17 | EvertonEverton | 0 - 1 | West HamWest Ham |
| 01 Jan 21 | r17 | Manchester UnitedManchester Un | 2 - 1 | Aston VillaAston Villa |
| 02 Jan 21 | r17 | TottenhamTottenham | 3 - 0 | LeedsLeeds |
| 02 Jan 21 | r17 | Crystal PalaceCrystal Palac | 2 - 0 | Sheffield UnitedSheffield Uni |
| 02 Jan 21 | r17 | BrightonBrighton | 3 - 3 | WolvesWolves |
| 02 Jan 21 | r17 | West BromWest Brom | 0 - 4 | ArsenalArsenal |
| 03 Jan 21 | r17 | NewcastleNewcastle | 1 - 2 | LeicesterLeicester |
| 03 Jan 21 | r17 | ChelseaChelsea | 1 - 3 | Manchester CityManchester Ci |
| 04 Jan 21 | r17 | SouthamptonSouthampton | 1 - 0 | LiverpoolLiverpool |
| |
| 12 Jan 21 | r18 | Sheffield UnitedSheffield Uni | 1 - 0 | NewcastleNewcastle |
| 12 Jan 21 | r18 | WolvesWolves | 1 - 2 | EvertonEverton |
| |
| 12 Jan 21 | r01 | BurnleyBurnley | 0 - 1 | Manchester UnitedManchester Un |
| |
| 13 Jan 21 | r18 | Manchester CityManchester Ci | 1 - 0 | BrightonBrighton |
| |
| 13 Jan 21 | r16 | TottenhamTottenham | 1 - 1 | FulhamFulham |
| |
| 14 Jan 21 | r18 | ArsenalArsenal | 0 - 0 | Crystal PalaceCrystal Palac |
| |
| 16 Jan 21 | r19 | WolvesWolves | 2 - 3 | West BromWest Brom |
| 16 Jan 21 | r19 | LeedsLeeds | 0 - 1 | BrightonBrighton |
| 16 Jan 21 | r19 | West HamWest Ham | 1 - 0 | BurnleyBurnley |
| 16 Jan 21 | r19 | FulhamFulham | 0 - 1 | ChelseaChelsea |
| 16 Jan 21 | r19 | LeicesterLeicester | 2 - 0 | SouthamptonSouthampton |
| 17 Jan 21 | r19 | Sheffield UnitedSheffield Uni | 1 - 3 | TottenhamTottenham |
| 17 Jan 21 | r19 | LiverpoolLiverpool | 0 - 0 | Manchester UnitedManchester Un |
| 17 Jan 21 | r19 | Manchester CityManchester Ci | 4 - 0 | Crystal PalaceCrystal Palac |
| 18 Jan 21 | r19 | ArsenalArsenal | 3 - 0 | NewcastleNewcastle |
| |
| 19 Jan 21 | r18 | West HamWest Ham | 2 - 1 | West BromWest Brom |
| 19 Jan 21 | r18 | LeicesterLeicester | 2 - 0 | ChelseaChelsea |
| |
| 20 Jan 21 | r01 | Manchester CityManchester Ci | 2 - 0 | Aston VillaAston Villa |
| |
| 20 Jan 21 | r18 | FulhamFulham | 1 - 2 | Manchester UnitedManchester Un |
| 21 Jan 21 | r18 | LiverpoolLiverpool | 0 - 1 | BurnleyBurnley |
| |
| 23 Jan 21 | r11 | Aston VillaAston Villa | 2 - 0 | NewcastleNewcastle |
| |
| 26 Jan 21 | r20 | NewcastleNewcastle | 1 - 2 | LeedsLeeds |
| 26 Jan 21 | r20 | Crystal PalaceCrystal Palac | 2 - 3 | West HamWest Ham |
| 26 Jan 21 | r20 | West BromWest Brom | 0 - 5 | Manchester CityManchester Ci |
| 26 Jan 21 | r20 | SouthamptonSouthampton | 1 - 3 | ArsenalArsenal |
| 27 Jan 21 | r20 | BurnleyBurnley | 3 - 2 | Aston VillaAston Villa |
| 27 Jan 21 | r20 | ChelseaChelsea | 0 - 0 | WolvesWolves |
| 27 Jan 21 | r20 | BrightonBrighton | 0 - 0 | FulhamFulham |
| 27 Jan 21 | r20 | EvertonEverton | 1 - 1 | LeicesterLeicester |
| 27 Jan 21 | r20 | Manchester UnitedManchester Un | 1 - 2 | Sheffield UnitedSheffield Uni |
| 28 Jan 21 | r20 | TottenhamTottenham | 1 - 3 | LiverpoolLiverpool |
| |
| 30 Jan 21 | r21 | EvertonEverton | 0 - 2 | NewcastleNewcastle |
| 30 Jan 21 | r21 | Crystal PalaceCrystal Palac | 1 - 0 | WolvesWolves |
| 30 Jan 21 | r21 | Manchester CityManchester Ci | 1 - 0 | Sheffield UnitedSheffield Uni |
| 30 Jan 21 | r21 | West BromWest Brom | 2 - 2 | FulhamFulham |
| 30 Jan 21 | r21 | ArsenalArsenal | 0 - 0 | Manchester UnitedManchester Un |
| 30 Jan 21 | r21 | SouthamptonSouthampton | 0 - 1 | Aston VillaAston Villa |
| 31 Jan 21 | r21 | ChelseaChelsea | 2 - 0 | BurnleyBurnley |
| 31 Jan 21 | r21 | LeicesterLeicester | 1 - 3 | LeedsLeeds |
| 31 Jan 21 | r21 | West HamWest Ham | 1 - 3 | LiverpoolLiverpool |
| 31 Jan 21 | r21 | BrightonBrighton | 1 - 0 | TottenhamTottenham |
| |
| 02 Feb 21 | r22 | Sheffield UnitedSheffield Uni | 2 - 1 | West BromWest Brom |
| 02 Feb 21 | r22 | WolvesWolves | 2 - 1 | ArsenalArsenal |
| 02 Feb 21 | r22 | Manchester UnitedManchester Un | 9 - 0 | SouthamptonSouthampton |
| 02 Feb 21 | r22 | NewcastleNewcastle | 1 - 2 | Crystal PalaceCrystal Palac |
| 03 Feb 21 | r22 | BurnleyBurnley | 0 - 2 | Manchester CityManchester Ci |
| 03 Feb 21 | r22 | FulhamFulham | 0 - 2 | LeicesterLeicester |
| 03 Feb 21 | r22 | LeedsLeeds | 1 - 2 | EvertonEverton |
| 03 Feb 21 | r22 | Aston VillaAston Villa | 1 - 3 | West HamWest Ham |
| 03 Feb 21 | r22 | LiverpoolLiverpool | 0 - 1 | BrightonBrighton |
| 04 Feb 21 | r22 | TottenhamTottenham | 0 - 1 | ChelseaChelsea |
| |
| 06 Feb 21 | r23 | Aston VillaAston Villa | 1 - 0 | ArsenalArsenal |
| 06 Feb 21 | r23 | BurnleyBurnley | 1 - 1 | BrightonBrighton |
| 06 Feb 21 | r23 | NewcastleNewcastle | 3 - 2 | SouthamptonSouthampton |
| 06 Feb 21 | r23 | FulhamFulham | 0 - 0 | West HamWest Ham |
| 06 Feb 21 | r23 | Manchester UnitedManchester Un | 3 - 3 | EvertonEverton |
| 07 Feb 21 | r23 | TottenhamTottenham | 2 - 0 | West BromWest Brom |
| 07 Feb 21 | r23 | WolvesWolves | 0 - 0 | LeicesterLeicester |
| 07 Feb 21 | r23 | LiverpoolLiverpool | 1 - 4 | Manchester CityManchester Ci |
| 07 Feb 21 | r23 | Sheffield UnitedSheffield Uni | 1 - 2 | ChelseaChelsea |
| 08 Feb 21 | r23 | LeedsLeeds | 2 - 0 | Crystal PalaceCrystal Palac |
| |
| 13 Feb 21 | r24 | LeicesterLeicester | 3 - 1 | LiverpoolLiverpool |
| 13 Feb 21 | r24 | Crystal PalaceCrystal Palac | 0 - 3 | BurnleyBurnley |
| 13 Feb 21 | r24 | Manchester CityManchester Ci | 3 - 0 | TottenhamTottenham |
| 13 Feb 21 | r24 | BrightonBrighton | 0 - 0 | Aston VillaAston Villa |
| 14 Feb 21 | r24 | SouthamptonSouthampton | 1 - 2 | WolvesWolves |
| 14 Feb 21 | r24 | West BromWest Brom | 1 - 1 | Manchester UnitedManchester Un |
| 14 Feb 21 | r24 | ArsenalArsenal | 4 - 2 | LeedsLeeds |
| 14 Feb 21 | r24 | EvertonEverton | 0 - 2 | FulhamFulham |
| 15 Feb 21 | r24 | West HamWest Ham | 3 - 0 | Sheffield UnitedSheffield Uni |
| 15 Feb 21 | r24 | ChelseaChelsea | 2 - 0 | NewcastleNewcastle |
| |
| 17 Feb 21 | r17 | BurnleyBurnley | 1 - 1 | FulhamFulham |
| |
| 17 Feb 21 | r16 | EvertonEverton | 1 - 3 | Manchester CityManchester Ci |
| |
| 19 Feb 21 | r25 | WolvesWolves | 1 - 0 | LeedsLeeds |
| 20 Feb 21 | r25 | SouthamptonSouthampton | 1 - 1 | ChelseaChelsea |
| 20 Feb 21 | r25 | BurnleyBurnley | 0 - 0 | West BromWest Brom |
| 20 Feb 21 | r25 | LiverpoolLiverpool | 0 - 2 | EvertonEverton |
| 20 Feb 21 | r25 | FulhamFulham | 1 - 0 | Sheffield UnitedSheffield Uni |
| 21 Feb 21 | r25 | West HamWest Ham | 2 - 1 | TottenhamTottenham |
| 21 Feb 21 | r25 | Aston VillaAston Villa | 1 - 2 | LeicesterLeicester |
| 21 Feb 21 | r25 | ArsenalArsenal | 0 - 1 | Manchester CityManchester Ci |
| 21 Feb 21 | r25 | Manchester UnitedManchester Un | 3 - 1 | NewcastleNewcastle |
| 22 Feb 21 | r25 | BrightonBrighton | 1 - 2 | Crystal PalaceCrystal Palac |
| |
| 23 Feb 21 | r18 | LeedsLeeds | 3 - 0 | SouthamptonSouthampton |
| |
| 27 Feb 21 | r26 | Manchester CityManchester Ci | 2 - 1 | West HamWest Ham |
| 27 Feb 21 | r26 | West BromWest Brom | 1 - 0 | BrightonBrighton |
| 27 Feb 21 | r26 | LeedsLeeds | 0 - 1 | Aston VillaAston Villa |
| 27 Feb 21 | r26 | NewcastleNewcastle | 1 - 1 | WolvesWolves |
| 28 Feb 21 | r26 | Crystal PalaceCrystal Palac | 0 - 0 | FulhamFulham |
| 28 Feb 21 | r26 | LeicesterLeicester | 1 - 3 | ArsenalArsenal |
| 28 Feb 21 | r26 | TottenhamTottenham | 4 - 0 | BurnleyBurnley |
| 28 Feb 21 | r26 | ChelseaChelsea | 0 - 0 | Manchester UnitedManchester Un |
| 28 Feb 21 | r26 | Sheffield UnitedSheffield Uni | 0 - 2 | LiverpoolLiverpool |
| 01 Mar 21 | r26 | EvertonEverton | 1 - 0 | SouthamptonSouthampton |
| |
| 02 Mar 21 | r29 | Manchester CityManchester Ci | 4 - 1 | WolvesWolves |
| 03 Mar 21 | r29 | BurnleyBurnley | 1 - 1 | LeicesterLeicester |
| 03 Mar 21 | r29 | Sheffield UnitedSheffield Uni | 1 - 0 | Aston VillaAston Villa |
| 03 Mar 21 | r29 | Crystal PalaceCrystal Palac | 0 - 0 | Manchester UnitedManchester Un |
| 04 Mar 21 | r29 | West BromWest Brom | 0 - 1 | EvertonEverton |
| |
| 04 Mar 21 | r33 | FulhamFulham | 0 - 1 | TottenhamTottenham |
| |
| 04 Mar 21 | r29 | LiverpoolLiverpool | 0 - 1 | ChelseaChelsea |
| |
| 06 Mar 21 | r27 | BurnleyBurnley | 1 - 1 | ArsenalArsenal |
| 06 Mar 21 | r27 | Sheffield UnitedSheffield Uni | 0 - 2 | SouthamptonSouthampton |
| 06 Mar 21 | r27 | Aston VillaAston Villa | 0 - 0 | WolvesWolves |
| 06 Mar 21 | r27 | BrightonBrighton | 1 - 2 | LeicesterLeicester |
| 07 Mar 21 | r27 | West BromWest Brom | 0 - 0 | NewcastleNewcastle |
| 07 Mar 21 | r27 | LiverpoolLiverpool | 0 - 1 | FulhamFulham |
| 07 Mar 21 | r27 | Manchester CityManchester Ci | 0 - 2 | Manchester UnitedManchester Un |
| 07 Mar 21 | r27 | TottenhamTottenham | 4 - 1 | Crystal PalaceCrystal Palac |
| 08 Mar 21 | r27 | ChelseaChelsea | 2 - 0 | EvertonEverton |
| 08 Mar 21 | r27 | West HamWest Ham | 2 - 0 | LeedsLeeds |
| |
| 10 Mar 21 | r33 | Manchester CityManchester Ci | 5 - 2 | SouthamptonSouthampton |
| |
| 12 Mar 21 | r28 | NewcastleNewcastle | 1 - 1 | Aston VillaAston Villa |
| 13 Mar 21 | r28 | LeedsLeeds | 0 - 0 | ChelseaChelsea |
| 13 Mar 21 | r28 | Crystal PalaceCrystal Palac | 1 - 0 | West BromWest Brom |
| 13 Mar 21 | r28 | EvertonEverton | 1 - 2 | BurnleyBurnley |
| 13 Mar 21 | r28 | FulhamFulham | 0 - 3 | Manchester CityManchester Ci |
| 14 Mar 21 | r28 | SouthamptonSouthampton | 1 - 2 | BrightonBrighton |
| 14 Mar 21 | r28 | LeicesterLeicester | 5 - 0 | Sheffield UnitedSheffield Uni |
| 14 Mar 21 | r28 | ArsenalArsenal | 2 - 1 | TottenhamTottenham |
| 14 Mar 21 | r28 | Manchester UnitedManchester Un | 1 - 0 | West HamWest Ham |
| 15 Mar 21 | r28 | WolvesWolves | 0 - 1 | LiverpoolLiverpool |
| |
| 19 Mar 21 | r29 | FulhamFulham | 1 - 2 | LeedsLeeds |
| 20 Mar 21 | r29 | BrightonBrighton | 3 - 0 | NewcastleNewcastle |
| 21 Mar 21 | r29 | West HamWest Ham | 3 - 3 | ArsenalArsenal |
| |
| 21 Mar 21 | r18 | Aston VillaAston Villa | 0 - 2 | TottenhamTottenham |
| |
| 03 Apr 21 | r30 | ChelseaChelsea | 2 - 5 | West BromWest Brom |
| 03 Apr 21 | r30 | LeedsLeeds | 2 - 1 | Sheffield UnitedSheffield Uni |
| 03 Apr 21 | r30 | LeicesterLeicester | 0 - 2 | Manchester CityManchester Ci |
| 03 Apr 21 | r30 | ArsenalArsenal | 0 - 3 | LiverpoolLiverpool |
| 04 Apr 21 | r30 | SouthamptonSouthampton | 3 - 2 | BurnleyBurnley |
| 04 Apr 21 | r30 | NewcastleNewcastle | 2 - 2 | TottenhamTottenham |
| 04 Apr 21 | r30 | Aston VillaAston Villa | 3 - 1 | FulhamFulham |
| 04 Apr 21 | r30 | Manchester UnitedManchester Un | 2 - 1 | BrightonBrighton |
| 05 Apr 21 | r30 | EvertonEverton | 1 - 1 | Crystal PalaceCrystal Palac |
| 05 Apr 21 | r30 | WolvesWolves | 2 - 3 | West HamWest Ham |
| |
| 09 Apr 21 | r31 | FulhamFulham | 0 - 1 | WolvesWolves |
| 10 Apr 21 | r31 | Manchester CityManchester Ci | 1 - 2 | LeedsLeeds |
| 10 Apr 21 | r31 | LiverpoolLiverpool | 2 - 1 | Aston VillaAston Villa |
| 10 Apr 21 | r31 | Crystal PalaceCrystal Palac | 1 - 4 | ChelseaChelsea |
| 11 Apr 21 | r31 | BurnleyBurnley | 1 - 2 | NewcastleNewcastle |
| 11 Apr 21 | r31 | West HamWest Ham | 3 - 2 | LeicesterLeicester |
| 11 Apr 21 | r31 | TottenhamTottenham | 1 - 3 | Manchester UnitedManchester Un |
| 11 Apr 21 | r31 | Sheffield UnitedSheffield Uni | 0 - 3 | ArsenalArsenal |
| 12 Apr 21 | r31 | West BromWest Brom | 3 - 0 | SouthamptonSouthampton |
| 12 Apr 21 | r31 | BrightonBrighton | 0 - 0 | EvertonEverton |
| |
| 16 Apr 21 | r32 | EvertonEverton | 2 - 2 | TottenhamTottenham |
| 17 Apr 21 | r32 | NewcastleNewcastle | 3 - 2 | West HamWest Ham |
| 17 Apr 21 | r32 | WolvesWolves | 1 - 0 | Sheffield UnitedSheffield Uni |
| 18 Apr 21 | r32 | ArsenalArsenal | 1 - 1 | FulhamFulham |
| 18 Apr 21 | r32 | Manchester UnitedManchester Un | 3 - 1 | BurnleyBurnley |
| 19 Apr 21 | r32 | LeedsLeeds | 1 - 1 | LiverpoolLiverpool |
| 20 Apr 21 | r32 | ChelseaChelsea | 0 - 0 | BrightonBrighton |
| |
| 21 Apr 21 | r29 | TottenhamTottenham | 2 - 1 | SouthamptonSouthampton |
| |
| 21 Apr 21 | r32 | Aston VillaAston Villa | 1 - 2 | Manchester CityManchester Ci |
| 22 Apr 21 | r32 | LeicesterLeicester | 3 - 0 | West BromWest Brom |
| |
| 23 Apr 21 | r33 | ArsenalArsenal | 0 - 1 | EvertonEverton |
| 24 Apr 21 | r33 | LiverpoolLiverpool | 1 - 1 | NewcastleNewcastle |
| 24 Apr 21 | r33 | West HamWest Ham | 0 - 1 | ChelseaChelsea |
| 24 Apr 21 | r33 | Sheffield UnitedSheffield Uni | 1 - 0 | BrightonBrighton |
| 25 Apr 21 | r33 | WolvesWolves | 0 - 4 | BurnleyBurnley |
| 25 Apr 21 | r33 | LeedsLeeds | 0 - 0 | Manchester UnitedManchester Un |
| 25 Apr 21 | r33 | Aston VillaAston Villa | 2 - 2 | West BromWest Brom |
| 26 Apr 21 | r33 | LeicesterLeicester | 2 - 1 | Crystal PalaceCrystal Palac |
| |
| 30 Apr 21 | r34 | SouthamptonSouthampton | 1 - 1 | LeicesterLeicester |
| 01 May 21 | r34 | Crystal PalaceCrystal Palac | 0 - 2 | Manchester CityManchester Ci |
| 01 May 21 | r34 | BrightonBrighton | 2 - 0 | LeedsLeeds |
| 01 May 21 | r34 | ChelseaChelsea | 2 - 0 | FulhamFulham |
| 01 May 21 | r34 | EvertonEverton | 1 - 2 | Aston VillaAston Villa |
| 02 May 21 | r34 | NewcastleNewcastle | 0 - 2 | ArsenalArsenal |
| 02 May 21 | r34 | TottenhamTottenham | 4 - 0 | Sheffield UnitedSheffield Uni |
| 03 May 21 | r34 | West BromWest Brom | 1 - 1 | WolvesWolves |
| 03 May 21 | r34 | BurnleyBurnley | 1 - 2 | West HamWest Ham |
| |
| 07 May 21 | r35 | LeicesterLeicester | 2 - 4 | NewcastleNewcastle |
| 08 May 21 | r35 | LeedsLeeds | 3 - 1 | TottenhamTottenham |
| 08 May 21 | r35 | Sheffield UnitedSheffield Uni | 0 - 2 | Crystal PalaceCrystal Palac |
| 08 May 21 | r35 | Manchester CityManchester Ci | 1 - 2 | ChelseaChelsea |
| 08 May 21 | r35 | LiverpoolLiverpool | 2 - 0 | SouthamptonSouthampton |
| 09 May 21 | r35 | WolvesWolves | 2 - 1 | BrightonBrighton |
| 09 May 21 | r35 | Aston VillaAston Villa | 1 - 3 | Manchester UnitedManchester Un |
| 09 May 21 | r35 | West HamWest Ham | 0 - 1 | EvertonEverton |
| 09 May 21 | r35 | ArsenalArsenal | 3 - 1 | West BromWest Brom |
| 10 May 21 | r35 | FulhamFulham | 0 - 2 | BurnleyBurnley |
| |
| 11 May 21 | r36 | Manchester UnitedManchester Un | 1 - 2 | LeicesterLeicester |
| |
| 11 May 21 | r32 | SouthamptonSouthampton | 3 - 1 | Crystal PalaceCrystal Palac |
| |
| 12 May 21 | r36 | ChelseaChelsea | 0 - 1 | ArsenalArsenal |
| |
| 13 May 21 | r19 | Aston VillaAston Villa | 0 - 0 | EvertonEverton |
| |
| 13 May 21 | r34 | Manchester UnitedManchester Un | 2 - 4 | LiverpoolLiverpool |
| |
| 14 May 21 | r36 | NewcastleNewcastle | 3 - 4 | Manchester CityManchester Ci |
| 15 May 21 | r36 | BurnleyBurnley | 0 - 4 | LeedsLeeds |
| 15 May 21 | r36 | SouthamptonSouthampton | 3 - 1 | FulhamFulham |
| 15 May 21 | r36 | BrightonBrighton | 1 - 1 | West HamWest Ham |
| 16 May 21 | r36 | Crystal PalaceCrystal Palac | 3 - 2 | Aston VillaAston Villa |
| 16 May 21 | r36 | TottenhamTottenham | 2 - 0 | WolvesWolves |
| 16 May 21 | r36 | West BromWest Brom | 1 - 2 | LiverpoolLiverpool |
| 16 May 21 | r36 | EvertonEverton | 0 - 1 | Sheffield UnitedSheffield Uni |
| |
| 18 May 21 | r37 | Manchester UnitedManchester Un | 1 - 1 | FulhamFulham |
| 18 May 21 | r37 | SouthamptonSouthampton | 0 - 2 | LeedsLeeds |
| 18 May 21 | r37 | BrightonBrighton | 3 - 2 | Manchester CityManchester Ci |
| 18 May 21 | r37 | ChelseaChelsea | 2 - 1 | LeicesterLeicester |
| 19 May 21 | r37 | EvertonEverton | 1 - 0 | WolvesWolves |
| 19 May 21 | r37 | NewcastleNewcastle | 1 - 0 | Sheffield UnitedSheffield Uni |
| 19 May 21 | r37 | TottenhamTottenham | 1 - 2 | Aston VillaAston Villa |
| 19 May 21 | r37 | Crystal PalaceCrystal Palac | 1 - 3 | ArsenalArsenal |
| 19 May 21 | r37 | BurnleyBurnley | 0 - 3 | LiverpoolLiverpool |
| 19 May 21 | r37 | West BromWest Brom | 1 - 3 | West HamWest Ham |
| |
| 23 May 21 | r38 | ArsenalArsenal | 2 - 0 | BrightonBrighton |
| 23 May 21 | r38 | Aston VillaAston Villa | 2 - 1 | ChelseaChelsea |
| 23 May 21 | r38 | FulhamFulham | 0 - 2 | NewcastleNewcastle |
| 23 May 21 | r38 | LeedsLeeds | 3 - 1 | West BromWest Brom |
| 23 May 21 | r38 | LeicesterLeicester | 2 - 4 | TottenhamTottenham |
| 23 May 21 | r38 | LiverpoolLiverpool | 2 - 0 | Crystal PalaceCrystal Palac |
| 23 May 21 | r38 | Manchester CityManchester Ci | 5 - 0 | EvertonEverton |
| 23 May 21 | r38 | Sheffield UnitedSheffield Uni | 1 - 0 | BurnleyBurnley |
| 23 May 21 | r38 | West HamWest Ham | 3 - 0 | SouthamptonSouthampton |
| 23 May 21 | r38 | WolvesWolves | 1 - 2 | Manchester UnitedManchester Un |
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