| 13 Aug 10 | r00        | Aston VillaAston Villa | 3 - 0 | West HamWest Ham |
| 13 Aug 10 | r00        | BlackburnBlackburn | 1 - 0 | EvertonEverton |
| 13 Aug 10 | r00        | BoltonBolton | 0 - 0 | FulhamFulham |
| 13 Aug 10 | r00        | ChelseaChelsea | 6 - 0 | West BromWest Brom |
| 13 Aug 10 | r00        | SunderlandSunderland | 2 - 2 | BirminghamBirmingham |
| 13 Aug 10 | r00        | TottenhamTottenham | 0 - 0 | Manchester CityManchester Ci |
| 13 Aug 10 | r00        | WiganWigan | 0 - 4 | BlackpoolBlackpool |
| 13 Aug 10 | r00        | WolvesWolves | 2 - 1 | StokeStoke |
| 14 Aug 10 | r00        | LiverpoolLiverpool | 1 - 1 | ArsenalArsenal |
| 15 Aug 10 | r00        | Manchester UnitedManchester Un | 3 - 0 | NewcastleNewcastle |
| 20 Aug 10 | r00        | ArsenalArsenal | 6 - 0 | BlackpoolBlackpool |
| 20 Aug 10 | r00        | BirminghamBirmingham | 2 - 1 | BlackburnBlackburn |
| 20 Aug 10 | r00        | EvertonEverton | 1 - 1 | WolvesWolves |
| 20 Aug 10 | r00        | StokeStoke | 1 - 2 | TottenhamTottenham |
| 20 Aug 10 | r00        | West BromWest Brom | 1 - 0 | SunderlandSunderland |
| 20 Aug 10 | r00        | West HamWest Ham | 1 - 3 | BoltonBolton |
| 20 Aug 10 | r00        | WiganWigan | 0 - 6 | ChelseaChelsea |
| 21 Aug 10 | r00        | FulhamFulham | 2 - 2 | Manchester UnitedManchester Un |
| 21 Aug 10 | r00        | NewcastleNewcastle | 6 - 0 | Aston VillaAston Villa |
| 22 Aug 10 | r00        | Manchester CityManchester Ci | 3 - 0 | LiverpoolLiverpool |
| 27 Aug 10 | r00        | BlackburnBlackburn | 1 - 2 | ArsenalArsenal |
| 27 Aug 10 | r00        | BlackpoolBlackpool | 2 - 2 | FulhamFulham |
| 27 Aug 10 | r00        | ChelseaChelsea | 2 - 0 | StokeStoke |
| 27 Aug 10 | r00        | Manchester UnitedManchester Un | 3 - 0 | West HamWest Ham |
| 27 Aug 10 | r00        | TottenhamTottenham | 0 - 1 | WiganWigan |
| 27 Aug 10 | r00        | WolvesWolves | 1 - 1 | NewcastleNewcastle |
| 28 Aug 10 | r00        | Aston VillaAston Villa | 1 - 0 | EvertonEverton |
| 28 Aug 10 | r00        | BoltonBolton | 2 - 2 | BirminghamBirmingham |
| 28 Aug 10 | r00        | LiverpoolLiverpool | 1 - 0 | West BromWest Brom |
| 28 Aug 10 | r00        | SunderlandSunderland | 1 - 0 | Manchester CityManchester Ci |
| 10 Sep 10 | r00        | ArsenalArsenal | 4 - 1 | BoltonBolton |
| 10 Sep 10 | r00        | EvertonEverton | 3 - 3 | Manchester UnitedManchester Un |
| 10 Sep 10 | r00        | FulhamFulham | 2 - 1 | WolvesWolves |
| 10 Sep 10 | r00        | Manchester CityManchester Ci | 1 - 1 | BlackburnBlackburn |
| 10 Sep 10 | r00        | NewcastleNewcastle | 0 - 2 | BlackpoolBlackpool |
| 10 Sep 10 | r00        | West BromWest Brom | 1 - 1 | TottenhamTottenham |
| 10 Sep 10 | r00        | West HamWest Ham | 1 - 3 | ChelseaChelsea |
| 10 Sep 10 | r00        | WiganWigan | 1 - 1 | SunderlandSunderland |
| 11 Sep 10 | r00        | BirminghamBirmingham | 0 - 0 | LiverpoolLiverpool |
| 12 Sep 10 | r00        | StokeStoke | 2 - 1 | Aston VillaAston Villa |
| 17 Sep 10 | r00        | Aston VillaAston Villa | 1 - 1 | BoltonBolton |
| 17 Sep 10 | r00        | BlackburnBlackburn | 1 - 1 | FulhamFulham |
| 17 Sep 10 | r00        | EvertonEverton | 0 - 1 | NewcastleNewcastle |
| 17 Sep 10 | r00        | StokeStoke | 1 - 1 | West HamWest Ham |
| 17 Sep 10 | r00        | SunderlandSunderland | 1 - 1 | ArsenalArsenal |
| 17 Sep 10 | r00        | TottenhamTottenham | 3 - 1 | WolvesWolves |
| 17 Sep 10 | r00        | West BromWest Brom | 3 - 1 | BirminghamBirmingham |
| 18 Sep 10 | r00        | ChelseaChelsea | 4 - 0 | BlackpoolBlackpool |
| 18 Sep 10 | r00        | Manchester UnitedManchester Un | 3 - 2 | LiverpoolLiverpool |
| 18 Sep 10 | r00        | WiganWigan | 0 - 2 | Manchester CityManchester Ci |
| 24 Sep 10 | r00        | ArsenalArsenal | 2 - 3 | West BromWest Brom |
| 24 Sep 10 | r00        | BirminghamBirmingham | 0 - 0 | WiganWigan |
| 24 Sep 10 | r00        | BlackpoolBlackpool | 1 - 2 | BlackburnBlackburn |
| 24 Sep 10 | r00        | FulhamFulham | 0 - 0 | EvertonEverton |
| 24 Sep 10 | r00        | LiverpoolLiverpool | 2 - 2 | SunderlandSunderland |
| 24 Sep 10 | r00        | Manchester CityManchester Ci | 1 - 0 | ChelseaChelsea |
| 24 Sep 10 | r00        | West HamWest Ham | 1 - 0 | TottenhamTottenham |
| 25 Sep 10 | r00        | BoltonBolton | 2 - 2 | Manchester UnitedManchester Un |
| 25 Sep 10 | r00        | NewcastleNewcastle | 1 - 2 | StokeStoke |
| 25 Sep 10 | r00        | WolvesWolves | 1 - 2 | Aston VillaAston Villa |
| 01 Oct 10 | r00        | BirminghamBirmingham | 0 - 2 | EvertonEverton |
| 01 Oct 10 | r00        | StokeStoke | 1 - 0 | BlackburnBlackburn |
| 01 Oct 10 | r00        | SunderlandSunderland | 0 - 0 | Manchester UnitedManchester Un |
| 01 Oct 10 | r00        | TottenhamTottenham | 2 - 1 | Aston VillaAston Villa |
| 01 Oct 10 | r00        | West BromWest Brom | 1 - 1 | BoltonBolton |
| 01 Oct 10 | r00        | West HamWest Ham | 1 - 1 | FulhamFulham |
| 01 Oct 10 | r00        | WiganWigan | 2 - 0 | WolvesWolves |
| 02 Oct 10 | r00        | ChelseaChelsea | 2 - 0 | ArsenalArsenal |
| 02 Oct 10 | r00        | LiverpoolLiverpool | 1 - 2 | BlackpoolBlackpool |
| 02 Oct 10 | r00        | Manchester CityManchester Ci | 2 - 1 | NewcastleNewcastle |
| 15 Oct 10 | r00        | ArsenalArsenal | 2 - 1 | BirminghamBirmingham |
| 15 Oct 10 | r00        | Aston VillaAston Villa | 0 - 0 | ChelseaChelsea |
| 15 Oct 10 | r00        | BoltonBolton | 2 - 1 | StokeStoke |
| 15 Oct 10 | r00        | FulhamFulham | 1 - 2 | TottenhamTottenham |
| 15 Oct 10 | r00        | Manchester UnitedManchester Un | 2 - 2 | West BromWest Brom |
| 15 Oct 10 | r00        | NewcastleNewcastle | 2 - 2 | WiganWigan |
| 15 Oct 10 | r00        | WolvesWolves | 1 - 1 | West HamWest Ham |
| 16 Oct 10 | r00        | BlackpoolBlackpool | 2 - 3 | Manchester CityManchester Ci |
| 16 Oct 10 | r00        | EvertonEverton | 2 - 0 | LiverpoolLiverpool |
| 17 Oct 10 | r00        | BlackburnBlackburn | 0 - 0 | SunderlandSunderland |
| 22 Oct 10 | r00        | BirminghamBirmingham | 2 - 0 | BlackpoolBlackpool |
| 22 Oct 10 | r00        | ChelseaChelsea | 2 - 0 | WolvesWolves |
| 22 Oct 10 | r00        | SunderlandSunderland | 1 - 0 | Aston VillaAston Villa |
| 22 Oct 10 | r00        | TottenhamTottenham | 1 - 1 | EvertonEverton |
| 22 Oct 10 | r00        | West BromWest Brom | 2 - 1 | FulhamFulham |
| 22 Oct 10 | r00        | West HamWest Ham | 1 - 2 | NewcastleNewcastle |
| 22 Oct 10 | r00        | WiganWigan | 1 - 1 | BoltonBolton |
| 23 Oct 10 | r00        | LiverpoolLiverpool | 2 - 1 | BlackburnBlackburn |
| 23 Oct 10 | r00        | Manchester CityManchester Ci | 0 - 3 | ArsenalArsenal |
| 23 Oct 10 | r00        | StokeStoke | 1 - 2 | Manchester UnitedManchester Un |
| 29 Oct 10 | r00        | ArsenalArsenal | 1 - 0 | West HamWest Ham |
| 29 Oct 10 | r00        | BlackburnBlackburn | 1 - 2 | ChelseaChelsea |
| 29 Oct 10 | r00        | EvertonEverton | 1 - 0 | StokeStoke |
| 29 Oct 10 | r00        | FulhamFulham | 2 - 0 | WiganWigan |
| 29 Oct 10 | r00        | Manchester UnitedManchester Un | 2 - 0 | TottenhamTottenham |
| 29 Oct 10 | r00        | WolvesWolves | 2 - 1 | Manchester CityManchester Ci |
| 30 Oct 10 | r00        | Aston VillaAston Villa | 0 - 0 | BirminghamBirmingham |
| 30 Oct 10 | r00        | BoltonBolton | 0 - 1 | LiverpoolLiverpool |
| 30 Oct 10 | r00        | NewcastleNewcastle | 5 - 1 | SunderlandSunderland |
| 31 Oct 10 | r00        | BlackpoolBlackpool | 2 - 1 | West BromWest Brom |