| 18 Aug 00 | r00  | CharltonCharlton | 4 - 0 | Manchester CityManchester Ci |
| 18 Aug 00 | r00 | ChelseaChelsea | 4 - 2 | West HamWest Ham |
| 18 Aug 00 | r00 | CoventryCoventry | 1 - 3 | MiddlesbroughMiddlesbrough |
| 18 Aug 00 | r00 | DerbyDerby | 2 - 2 | SouthamptonSouthampton |
| 18 Aug 00 | r00 | LeedsLeeds | 2 - 0 | EvertonEverton |
| 18 Aug 00 | r00 | LeicesterLeicester | 0 - 0 | Aston VillaAston Villa |
| 18 Aug 00 | r00 | LiverpoolLiverpool | 1 - 0 | BradfordBradford |
| 18 Aug 00 | r00 | SunderlandSunderland | 1 - 0 | ArsenalArsenal |
| 18 Aug 00 | r00 | TottenhamTottenham | 3 - 1 | IpswichIpswich |
| 19 Aug 00 | r00 | Manchester UnitedManchester Un | 2 - 0 | NewcastleNewcastle |
| 20 Aug 00 | r00 | ArsenalArsenal | 2 - 0 | LiverpoolLiverpool |
| 21 Aug 00 | r00 | BradfordBradford | 2 - 0 | ChelseaChelsea |
| 21 Aug 00 | r00 | IpswichIpswich | 1 - 1 | Manchester UnitedManchester Un |
| 21 Aug 00 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | TottenhamTottenham |
| 22 Aug 00 | r00 | EvertonEverton | 3 - 0 | CharltonCharlton |
| 22 Aug 00 | r00 | Manchester CityManchester Ci | 4 - 2 | SunderlandSunderland |
| 22 Aug 00 | r00 | NewcastleNewcastle | 3 - 2 | DerbyDerby |
| 22 Aug 00 | r00 | SouthamptonSouthampton | 1 - 2 | CoventryCoventry |
| 22 Aug 00 | r00 | West HamWest Ham | 0 - 1 | LeicesterLeicester |
| 25 Aug 00 | r00 | ArsenalArsenal | 5 - 3 | CharltonCharlton |
| 25 Aug 00 | r00 | BradfordBradford | 0 - 0 | LeicesterLeicester |
| 25 Aug 00 | r00 | EvertonEverton | 2 - 2 | DerbyDerby |
| 25 Aug 00 | r00 | IpswichIpswich | 1 - 0 | SunderlandSunderland |
| 25 Aug 00 | r00 | Manchester CityManchester Ci | 1 - 2 | CoventryCoventry |
| 25 Aug 00 | r00 | MiddlesbroughMiddlesbrough | 1 - 2 | LeedsLeeds |
| 25 Aug 00 | r00 | NewcastleNewcastle | 2 - 0 | TottenhamTottenham |
| 25 Aug 00 | r00 | SouthamptonSouthampton | 3 - 3 | LiverpoolLiverpool |
| 25 Aug 00 | r00 | West HamWest Ham | 2 - 2 | Manchester UnitedManchester Un |
| 26 Aug 00 | r00 | Aston VillaAston Villa | 1 - 1 | ChelseaChelsea |
| 04 Sep 00 | r00 | LeedsLeeds | 1 - 2 | Manchester CityManchester Ci |
| 04 Sep 00 | r00 | Manchester UnitedManchester Un | 6 - 0 | BradfordBradford |
| 04 Sep 00 | r00 | SunderlandSunderland | 1 - 1 | West HamWest Ham |
| 04 Sep 00 | r00 | TottenhamTottenham | 3 - 2 | EvertonEverton |
| 05 Sep 00 | r00 | CharltonCharlton | 1 - 1 | SouthamptonSouthampton |
| 05 Sep 00 | r00 | ChelseaChelsea | 2 - 2 | ArsenalArsenal |
| 05 Sep 00 | r00 | CoventryCoventry | 0 - 2 | NewcastleNewcastle |
| 05 Sep 00 | r00 | DerbyDerby | 3 - 3 | MiddlesbroughMiddlesbrough |
| 05 Sep 00 | r00 | LeicesterLeicester | 2 - 1 | IpswichIpswich |
| 05 Sep 00 | r00 | LiverpoolLiverpool | 3 - 1 | Aston VillaAston Villa |
| 08 Sep 00 | r00 | BradfordBradford | 1 - 1 | ArsenalArsenal |
| 08 Sep 00 | r00 | CoventryCoventry | 0 - 0 | LeedsLeeds |
| 08 Sep 00 | r00 | IpswichIpswich | 1 - 2 | Aston VillaAston Villa |
| 08 Sep 00 | r00 | LeicesterLeicester | 1 - 0 | SouthamptonSouthampton |
| 08 Sep 00 | r00 | LiverpoolLiverpool | 3 - 2 | Manchester CityManchester Ci |
| 08 Sep 00 | r00 | Manchester UnitedManchester Un | 3 - 0 | SunderlandSunderland |
| 08 Sep 00 | r00 | MiddlesbroughMiddlesbrough | 1 - 2 | EvertonEverton |
| 08 Sep 00 | r00 | NewcastleNewcastle | 0 - 0 | ChelseaChelsea |
| 09 Sep 00 | r00 | DerbyDerby | 2 - 2 | CharltonCharlton |
| 10 Sep 00 | r00 | TottenhamTottenham | 1 - 0 | West HamWest Ham |
| 15 Sep 00 | r00 | ArsenalArsenal | 2 - 1 | CoventryCoventry |
| 15 Sep 00 | r00 | Aston VillaAston Villa | 2 - 0 | BradfordBradford |
| 15 Sep 00 | r00 | CharltonCharlton | 1 - 0 | TottenhamTottenham |
| 15 Sep 00 | r00 | EvertonEverton | 1 - 3 | Manchester UnitedManchester Un |
| 15 Sep 00 | r00 | LeedsLeeds | 1 - 2 | IpswichIpswich |
| 15 Sep 00 | r00 | SouthamptonSouthampton | 2 - 0 | NewcastleNewcastle |
| 15 Sep 00 | r00 | SunderlandSunderland | 2 - 1 | DerbyDerby |
| 16 Sep 00 | r00 | ChelseaChelsea | 0 - 2 | LeicesterLeicester |
| 16 Sep 00 | r00 | Manchester CityManchester Ci | 1 - 1 | MiddlesbroughMiddlesbrough |
| 16 Sep 00 | r00 | West HamWest Ham | 1 - 1 | LiverpoolLiverpool |
| 22 Sep 00 | r00 | BradfordBradford | 0 - 1 | SouthamptonSouthampton |
| 22 Sep 00 | r00 | CoventryCoventry | 0 - 3 | West HamWest Ham |
| 22 Sep 00 | r00 | DerbyDerby | 1 - 1 | LeedsLeeds |
| 22 Sep 00 | r00 | IpswichIpswich | 1 - 1 | ArsenalArsenal |
| 22 Sep 00 | r00 | LiverpoolLiverpool | 1 - 1 | SunderlandSunderland |
| 22 Sep 00 | r00 | Manchester UnitedManchester Un | 3 - 3 | ChelseaChelsea |
| 22 Sep 00 | r00 | MiddlesbroughMiddlesbrough | 1 - 1 | Aston VillaAston Villa |
| 22 Sep 00 | r00 | NewcastleNewcastle | 0 - 1 | CharltonCharlton |
| 22 Sep 00 | r00 | TottenhamTottenham | 0 - 0 | Manchester CityManchester Ci |
| 23 Sep 00 | r00 | LeicesterLeicester | 1 - 1 | EvertonEverton |
| 29 Sep 00 | r00 | Aston VillaAston Villa | 4 - 1 | DerbyDerby |
| 29 Sep 00 | r00 | CharltonCharlton | 2 - 2 | CoventryCoventry |
| 29 Sep 00 | r00 | EvertonEverton | 0 - 3 | IpswichIpswich |
| 29 Sep 00 | r00 | LeedsLeeds | 4 - 3 | TottenhamTottenham |
| 29 Sep 00 | r00 | Manchester CityManchester Ci | 0 - 1 | NewcastleNewcastle |
| 29 Sep 00 | r00 | SouthamptonSouthampton | 1 - 3 | MiddlesbroughMiddlesbrough |
| 29 Sep 00 | r00 | West HamWest Ham | 1 - 1 | BradfordBradford |
| 30 Sep 00 | r00 | ArsenalArsenal | 1 - 0 | Manchester UnitedManchester Un |
| 30 Sep 00 | r00 | ChelseaChelsea | 3 - 0 | LiverpoolLiverpool |
| 30 Sep 00 | r00 | SunderlandSunderland | 0 - 0 | LeicesterLeicester |
| 13 Oct 00 | r00 | ArsenalArsenal | 1 - 0 | Aston VillaAston Villa |
| 13 Oct 00 | r00 | CoventryCoventry | 2 - 1 | TottenhamTottenham |
| 13 Oct 00 | r00 | EvertonEverton | 1 - 1 | SouthamptonSouthampton |
| 13 Oct 00 | r00 | IpswichIpswich | 1 - 1 | West HamWest Ham |
| 13 Oct 00 | r00 | LeedsLeeds | 3 - 1 | CharltonCharlton |
| 13 Oct 00 | r00 | LeicesterLeicester | 0 - 3 | Manchester UnitedManchester Un |
| 13 Oct 00 | r00 | Manchester CityManchester Ci | 2 - 0 | BradfordBradford |
| 13 Oct 00 | r00 | SunderlandSunderland | 1 - 0 | ChelseaChelsea |
| 14 Oct 00 | r00 | DerbyDerby | 0 - 4 | LiverpoolLiverpool |
| 15 Oct 00 | r00 | MiddlesbroughMiddlesbrough | 1 - 3 | NewcastleNewcastle |
| 20 Oct 00 | r00 | BradfordBradford | 0 - 2 | IpswichIpswich |
| 20 Oct 00 | r00 | CharltonCharlton | 1 - 0 | MiddlesbroughMiddlesbrough |
| 20 Oct 00 | r00 | ChelseaChelsea | 6 - 1 | CoventryCoventry |
| 20 Oct 00 | r00 | LiverpoolLiverpool | 1 - 0 | LeicesterLeicester |
| 20 Oct 00 | r00 | Manchester UnitedManchester Un | 3 - 0 | LeedsLeeds |
| 20 Oct 00 | r00 | NewcastleNewcastle | 0 - 1 | EvertonEverton |
| 20 Oct 00 | r00 | TottenhamTottenham | 3 - 1 | DerbyDerby |
| 20 Oct 00 | r00 | West HamWest Ham | 1 - 2 | ArsenalArsenal |
| 21 Oct 00 | r00 | Aston VillaAston Villa | 0 - 0 | SunderlandSunderland |
| 22 Oct 00 | r00 | SouthamptonSouthampton | 0 - 2 | Manchester CityManchester Ci |
| 27 Oct 00 | r00 | ArsenalArsenal | 5 - 0 | Manchester CityManchester Ci |
Team 2000-2001 Schedules
Arsenal
Aston Villa
Bournemouth
Brentford
Brighton and Hove Albion
Chelsea
Coventry City
Crystal Palace
Everton
Fulham
Hull City
Ipswich Town
Leeds United
Liverpool
Manchester City
Manchester United
Newcastle United
Nottingham Forest
Sunderland
Tottenham Hotspur
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