


Isaiah McGuire (born July 27, 2001) is an American professional football defensive end for the Cleveland Browns of the National Football League (NFL). He played college football for the Missouri Tigers.
Early life
McGuire attended Union High School in Tulsa, Oklahoma. He committed to the University of Missouri to play college football.
College career
As a true freshman at Missouri in 2019, McGuire played in six games and had four tackles. In five games in 2020, he had 18 tackles and three sacks. He started all 13 games his junior year in 2021, recording 55 tackles and six sacks. McGuire returned to Missouri his final year of eligibility in 2022. The senior appeared in 12 games, recording 39 tackles, 13 tackles for a loss, and 7.5 sacks.
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Milestones
Former Youth Teams ![]()






| Quarter Back Hit | NFL | 2024 | 9 |
| Turnover Forced Fumbles | NFL | 2024 | 3 |
| Tackle For a loss | NFL | 2024 | 8 |
| Tackle Sacks | NFL | 2024 | 2.5 |
| Tackle Assists | NFL | 2024 | 18 |
| Total Tackles | NFL | 2024 | 18 |