| 21 Sep 21 | r00  | Alliance Sport AlsaceAlliance Spor | 67 - 74 | Denain Voltaire BasketDenain Voltai |
| 21 Sep 21 | r00 | BC Gries OberhoffenBC Gries Ober | - | Denain Voltaire BasketDenain Voltai |
| 21 Sep 21 | r00 | Stade Rochelais BasketStade Rochela | 78 - 93 | Boulazac Basket DordogneBoulazac Bask |
| 21 Sep 21 | r00 | UJAP Quimper 29UJAP Quimper | 76 - 53 | Caen Basket CalvadosCaen Basket C |
| 22 Sep 21 | r00 | Paris BasketballParis Basketb | 94 - 80 | Étoile Angers BasketÉtoile Angers |
| 22 Sep 21 | r00 | JA Vichy-Clermont MétropoJA Vichy-Cler | 82 - 80 | Élan ChalonÉlan Chalon |
| 22 Sep 21 | r00 | Saint-Vallier Basket DrômSaint-Vallier | 76 - 82 | Fos Provence BasketFos Provence |
| 18 Oct 21 | r00 | Union Tours Basket MétropUnion Tours B | 64 - 80 | Pau-Lacq-OrthezPau-Lacq-Orth |
| 19 Oct 21 | r00 | JA Vichy-Clermont MétropoJA Vichy-Cler | 86 - 83 | Antibes SharksAntibes Shark |
| 19 Oct 21 | r00 | AMSBAMSB | 90 - 91 | Chorale Roanne BasketChorale Roann |
| 19 Oct 21 | r00 | Boulazac Basket DordogneBoulazac Bask | 68 - 63 | UJAP Quimper 29UJAP Quimper |
| 19 Oct 21 | r00 | CholetCholet | 87 - 77 | Poitiers Basket 86Poitiers Bask |
| 19 Oct 21 | r00 | Denain Voltaire BasketDenain Voltai | 64 - 98 | Gravelines-DunkerqueGravelines-Du |
| 19 Oct 21 | r00 | NanterreNanterre | 77 - 85 | Saint-Quentin Basket-BallSaint-Quentin |
| 19 Oct 21 | r00 | Hermine Nantes BasketHermine Nante | 61 - 84 | LimogesLimoges |
| 19 Oct 21 | r00 | BC OrchiesBC Orchies | 60 - 62 | ALM Évreux BasketALM Évreux Ba |
| 19 Oct 21 | r00 | Lille Métropole BCLille Métropo | 71 - 81 | Châlons-ReimsChâlons-Reims |
| 20 Oct 21 | r00 | Paris BasketballParis Basketb | 107 - 81 | RouenRouen |
| 16 Nov 21 | r00 | Boulazac Basket DordogneBoulazac Bask | 75 - 70 | ALM Évreux BasketALM Évreux Ba |
| 16 Nov 21 | r00 | JA Vichy-Clermont MétropoJA Vichy-Cler | 98 - 78 | Châlons-ReimsChâlons-Reims |
| 16 Nov 21 | r00 | Paris BasketballParis Basketb | 89 - 73 | Chorale Roanne BasketChorale Roann |
| 16 Nov 21 | r00 | Pau-Lacq-OrthezPau-Lacq-Orth | 99 - 92 | CholetCholet |
| 16 Nov 21 | r00 | Saint-Quentin Basket-BallSaint-Quentin | 76 - 57 | ADA BloisADA Blois |
| 17 Nov 21 | r00 | Gravelines-DunkerqueGravelines-Du | 92 - 61 | SLUC Nancy BasketSLUC Nancy Ba |
| 15 Feb 22 | r00 | Bourg-en-BresseBourg-en-Bres | 88 - 82 | LimogesLimoges |
| 15 Feb 22 | r00 | Fos Provence BasketFos Provence | 81 - 68 | Boulazac Basket DordogneBoulazac Bask |
| 15 Feb 22 | r00 | StrasbourgStrasbourg | 94 - 90 | DijonDijon |
| 16 Feb 22 | r00 | AS Monaco BasketAS Monaco Bas | 92 - 76 | Le Mans Sarthe BasketLe Mans Sarth |
| 16 Feb 22 | r00 | Lyon-VilleurbanneLyon-Villeurb | 90 - 70 | JA Vichy-Clermont MétropoJA Vichy-Cler |
| 16 Feb 22 | r00 | Orléans Loiret BasketOrléans Loire | 70 - 77 | Pau-Lacq-OrthezPau-Lacq-Orth |
| 16 Feb 22 | r00 | Saint-Quentin Basket-BallSaint-Quentin | 105 - 111 | Gravelines-DunkerqueGravelines-Du |
| 17 Feb 22 | r00 | Metropolitans 92Metropolitans | 88 - 81 | Paris BasketballParis Basketb |
| 26 Mar 22 | r00 | Pau-Lacq-OrthezPau-Lacq-Orth | 93 - 72 | Fos Provence BasketFos Provence |
| 26 Mar 22 | r00 | StrasbourgStrasbourg | 95 - 87 | Metropolitans 92Metropolitans |
| 26 Mar 22 | r00 | AS Monaco BasketAS Monaco Bas | 74 - 65 | Bourg-en-BresseBourg-en-Bres |
| 26 Mar 22 | r00 | Lyon-VilleurbanneLyon-Villeurb | 78 - 79 | Gravelines-DunkerqueGravelines-Du |
| 27 Mar 22 | r00 | StrasbourgStrasbourg | 86 - 73 | AS Monaco BasketAS Monaco Bas |
| 27 Mar 22 | r00 | Pau-Lacq-OrthezPau-Lacq-Orth | 88 - 85 | Gravelines-DunkerqueGravelines-Du |
| 23 Apr 22 | r00 | Pau-Lacq-OrthezPau-Lacq-Orth | 95 - 86 | StrasbourgStrasbourg |
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