| 22 Oct 22 | r12        | Bedworth UnitedBedworth Unit | 3 - 0 | Gresley RoversGresley Rover |
| 22 Oct 22 | r12        | Boldmere St MichaelsBoldmere St M | 3 - 1 | Cambridge CityCambridge Cit |
| 22 Oct 22 | r12        | ChasetownChasetown | 0 - 2 | Coleshill TownColeshill Tow |
| 22 Oct 22 | r12        | Corby TownCorby Town | 3 - 0 | Dereham TownDereham Town |
| 22 Oct 22 | r12        | DaventryDaventry | 3 - 2 | Shepshed DynamoShepshed Dyna |
| 22 Oct 22 | r12        | Halesowen TownHalesowen Tow | 3 - 0 | Hinckley Leicester RoadHinckley Leic |
| 22 Oct 22 | r12        | Harborough TownHarborough To | 1 - 1 | St Neots TownSt Neots Town |
| 22 Oct 22 | r12        | Loughborough DynamoLoughborough | 0 - 4 | Spalding UnitedSpalding Unit |
| 22 Oct 22 | r12        | Stamford AFCStamford AFC | 0 - 3 | Sutton Coldfield TownSutton Coldfi |
| 22 Oct 22 | r12        | YaxleyYaxley | 0 - 4 | Sporting KhalsaSporting Khal |