| 07 Mar 25 | r01   | Austin FC IIAustin FC II | 4 - 2 | Colorado Rapids 2Colorado Rapi |
| 08 Mar 25 | r01 | Crown LegacyCrown Legacy | 2 - 2 | New York City FC IINew York City |
| 08 Mar 25 | r01 | Inter Miami IIInter Miami I | 1 - 2 | Chattanooga FCChattanooga F |
| 08 Mar 25 | r01 | Atlanta United IIAtlanta Unite | 0 - 1 | New York Red Bulls IINew York Red |
| 08 Mar 25 | r01 | Ventura CountyVentura Count | 3 - 2 | Tacoma DefianceTacoma Defian |
| 09 Mar 25 | r01 | Houston Dynamo 2Houston Dynam | 3 - 1 | Sporting Kansas City IISporting Kans |
| 09 Mar 25 | r01 | New England Revolution IINew England R | 0 - 0 | Philadelphia Union IIPhiladelphia |
| 09 Mar 25 | r01 | Chicago Fire IIChicago Fire | 1 - 4 | Huntsville CityHuntsville Ci |
| 09 Mar 25 | r01 | FC Cincinnati 2FC Cincinnati | 0 - 1 | Toronto FC IIToronto FC II |
| 09 Mar 25 | r01 | Orlando City BOrlando City | 2 - 1 | Columbus Crew 2Columbus Crew |
| |
| 10 Mar 25 | r02 | North Texas SCNorth Texas S | 0 - 3 | St. Louis City SC 2St. Louis Cit |
| 10 Mar 25 | r02 | Los Angeles FC IILos Angeles F | 3 - 3 | Whitecaps FC 2Whitecaps FC |
| 13 Mar 25 | r02 | New England Revolution IINew England R | 2 - 0 | FC Cincinnati 2FC Cincinnati |
| 13 Mar 25 | r02 | Inter Miami IIInter Miami I | 1 - 1 | Carolina CoreCarolina Core |
| 14 Mar 25 | r02 | Chicago Fire IIChicago Fire | 1 - 0 | Toronto FC IIToronto FC II |
| 14 Mar 25 | r02 | Austin FC IIAustin FC II | 0 - 1 | Minnesota United FC 2Minnesota Uni |
| 14 Mar 25 | r02 | Sporting Kansas City IISporting Kans | 0 - 1 | St. Louis City SC 2St. Louis Cit |
| 14 Mar 25 | r02 | New York City FC IINew York City | 2 - 0 | Columbus Crew 2Columbus Crew |
| 15 Mar 25 | r02 | North Texas SCNorth Texas S | 3 - 2 | Whitecaps FC 2Whitecaps FC |
| 15 Mar 25 | r02 | Los Angeles FC IILos Angeles F | 3 - 1 | Ventura CountyVentura Count |
| |
| 15 Mar 25 | r03 | Tacoma DefianceTacoma Defian | 3 - 1 | The Town FCThe Town FC |
| 15 Mar 25 | r03 | Chattanooga FCChattanooga F | 1 - 0 | Huntsville CityHuntsville Ci |
| 16 Mar 25 | r03 | Portland Timbers IIPortland Timb | 2 - 3 | Real MonarchsReal Monarchs |
| 16 Mar 25 | r03 | Orlando City BOrlando City | 2 - 2 | Atlanta United IIAtlanta Unite |
| 17 Mar 25 | r03 | Philadelphia Union IIPhiladelphia | 1 - 1 | New York Red Bulls IINew York Red |
| 23 Mar 25 | r03 | St. Louis City SC 2St. Louis Cit | 2 - 0 | Sporting Kansas City IISporting Kans |
| 23 Mar 25 | r03 | Houston Dynamo 2Houston Dynam | 5 - 1 | North Texas SCNorth Texas S |
| |
| 23 Mar 25 | r19 | Inter Miami IIInter Miami I | 4 - 2 | Columbus Crew 2Columbus Crew |
| |
| 24 Mar 25 | r13 | Real MonarchsReal Monarchs | 2 - 2 | Colorado Rapids 2Colorado Rapi |
| |
| 24 Mar 25 | r03 | New York City FC IINew York City | 2 - 1 | Carolina CoreCarolina Core |
| |
| 26 Mar 25 | r04 | Crown LegacyCrown Legacy | 0 - 1 | Orlando City BOrlando City |
| 27 Mar 25 | r04 | Ventura CountyVentura Count | 1 - 0 | Houston Dynamo 2Houston Dynam |
| 27 Mar 25 | r04 | Portland Timbers IIPortland Timb | 1 - 1 | The Town FCThe Town FC |
| 28 Mar 25 | r04 | New England Revolution IINew England R | 4 - 0 | Toronto FC IIToronto FC II |
| 29 Mar 25 | r04 | Huntsville CityHuntsville Ci | 2 - 2 | Philadelphia Union IIPhiladelphia |
| 29 Mar 25 | r04 | North Texas SCNorth Texas S | 3 - 3 | Sporting Kansas City IISporting Kans |
| 29 Mar 25 | r04 | Whitecaps FC 2Whitecaps FC | 1 - 1 | Portland Timbers IIPortland Timb |
| 30 Mar 25 | r04 | New York Red Bulls IINew York Red | 3 - 2 | New York City FC IINew York City |
| |
| 30 Mar 25 | r05 | Atlanta United IIAtlanta Unite | 2 - 2 | Chattanooga FCChattanooga F |
| |
| 30 Mar 25 | r04 | FC Cincinnati 2FC Cincinnati | 1 - 2 | Chicago Fire IIChicago Fire |
| 30 Mar 25 | r04 | St. Louis City SC 2St. Louis Cit | 0 - 0 | Austin FC IIAustin FC II |
| |
| 31 Mar 25 | r05 | Houston Dynamo 2Houston Dynam | 1 - 3 | Minnesota United FC 2Minnesota Uni |
| 05 Apr 25 | r05 | Portland Timbers IIPortland Timb | 1 - 2 | North Texas SCNorth Texas S |
| 05 Apr 25 | r05 | Carolina CoreCarolina Core | 5 - 0 | New York City FC IINew York City |
| 05 Apr 25 | r05 | Chattanooga FCChattanooga F | 2 - 0 | Orlando City BOrlando City |
| 06 Apr 25 | r05 | New York Red Bulls IINew York Red | 3 - 2 | Chicago Fire IIChicago Fire |
| 06 Apr 25 | r05 | St. Louis City SC 2St. Louis Cit | 0 - 1 | Colorado Rapids 2Colorado Rapi |
| 06 Apr 25 | r05 | Columbus Crew 2Columbus Crew | 1 - 1 | Crown LegacyCrown Legacy |
| 06 Apr 25 | r05 | Houston Dynamo 2Houston Dynam | 1 - 0 | Los Angeles FC IILos Angeles F |
| 07 Apr 25 | r05 | Real MonarchsReal Monarchs | 1 - 2 | Ventura CountyVentura Count |
| |
| 07 Apr 25 | r06  | Tacoma DefianceTacoma Defian | 5 - 3 | Whitecaps FC 2Whitecaps FC |
| 07 Apr 25 | r06 | Atlanta United IIAtlanta Unite | 3 - 2 | Inter Miami IIInter Miami I |
| 09 Apr 25 | r06 | Orlando City BOrlando City | 1 - 0 | New England Revolution IINew England R |
| 09 Apr 25 | r06 | Sporting Kansas City IISporting Kans | 2 - 4 | Minnesota United FC 2Minnesota Uni |
| 09 Apr 25 | r06 | New York City FC IINew York City | 2 - 2 | FC Cincinnati 2FC Cincinnati |
| 10 Apr 25 | r06 | Inter Miami IIInter Miami I | 0 - 1 | Toronto FC IIToronto FC II |
| 10 Apr 25 | r06 | Philadelphia Union IIPhiladelphia | 5 - 1 | Atlanta United IIAtlanta Unite |
| |
| 11 Apr 25 | r27 | Real MonarchsReal Monarchs | 2 - 1 | The Town FCThe Town FC |
| |
| 11 Apr 25 | r06 | Los Angeles FC IILos Angeles F | 3 - 2 | Tacoma DefianceTacoma Defian |
| 12 Apr 25 | r06 | Austin FC IIAustin FC II | 1 - 1 | North Texas SCNorth Texas S |
| |
| 13 Apr 25 | r07 | Carolina CoreCarolina Core | 1 - 4 | Chattanooga FCChattanooga F |
| 13 Apr 25 | r07 | Portland Timbers IIPortland Timb | 1 - 2 | Colorado Rapids 2Colorado Rapi |
| 13 Apr 25 | r07 | Crown LegacyCrown Legacy | 1 - 1 | Huntsville CityHuntsville Ci |
| 14 Apr 25 | r07 | Ventura CountyVentura Count | 3 - 1 | St. Louis City SC 2St. Louis Cit |
| 15 Apr 25 | r07 | Inter Miami IIInter Miami I | 3 - 2 | Orlando City BOrlando City |
| 18 Apr 25 | r07 | Toronto FC IIToronto FC II | 1 - 1 | Carolina CoreCarolina Core |
| 19 Apr 25 | r07 | Chattanooga FCChattanooga F | 2 - 1 | Crown LegacyCrown Legacy |
| |
| 19 Apr 25 | r08 | Whitecaps FC 2Whitecaps FC | 4 - 0 | Austin FC IIAustin FC II |
| 20 Apr 25 | r08 | FC Cincinnati 2FC Cincinnati | 3 - 1 | New York Red Bulls IINew York Red |
| 20 Apr 25 | r08 | Huntsville CityHuntsville Ci | 5 - 0 | Chicago Fire IIChicago Fire |
| 21 Apr 25 | r08 | North Texas SCNorth Texas S | 2 - 3 | Colorado Rapids 2Colorado Rapi |
| 23 Apr 25 | r08 | New England Revolution IINew England R | 2 - 2 | Columbus Crew 2Columbus Crew |
| 23 Apr 25 | r08 | Real MonarchsReal Monarchs | 1 - 1 | Los Angeles FC IILos Angeles F |
| 23 Apr 25 | r08 | Sporting Kansas City IISporting Kans | 1 - 4 | Tacoma DefianceTacoma Defian |
| 23 Apr 25 | r08 | Atlanta United IIAtlanta Unite | 2 - 2 | Carolina CoreCarolina Core |
| 23 Apr 25 | r08 | New York City FC IINew York City | 1 - 4 | Philadelphia Union IIPhiladelphia |
| |
| 24 Apr 25 | r09 | North Texas SCNorth Texas S | 2 - 0 | The Town FCThe Town FC |
| 24 Apr 25 | r09 | Whitecaps FC 2Whitecaps FC | 1 - 3 | Houston Dynamo 2Houston Dynam |
| 24 Apr 25 | r09 | Ventura CountyVentura Count | 2 - 3 | Portland Timbers IIPortland Timb |
| 25 Apr 25 | r09 | Colorado Rapids 2Colorado Rapi | 0 - 2 | Minnesota United FC 2Minnesota Uni |
| 25 Apr 25 | r09 | Toronto FC IIToronto FC II | 2 - 0 | Chicago Fire IIChicago Fire |
| 26 Apr 25 | r09 | New England Revolution IINew England R | 2 - 1 | New York City FC IINew York City |
| 26 Apr 25 | r09 | Carolina CoreCarolina Core | 1 - 2 | Crown LegacyCrown Legacy |
| 27 Apr 25 | r09 | Tacoma DefianceTacoma Defian | 4 - 1 | St. Louis City SC 2St. Louis Cit |
| 27 Apr 25 | r09 | FC Cincinnati 2FC Cincinnati | 0 - 0 | Atlanta United IIAtlanta Unite |
| |
| 27 Apr 25 | r10 | Colorado Rapids 2Colorado Rapi | 3 - 0 | Sporting Kansas City IISporting Kans |
| |
| 27 Apr 25 | r09 | Columbus Crew 2Columbus Crew | 3 - 0 | Chattanooga FCChattanooga F |
| |
| 27 Apr 25 | r10 | Houston Dynamo 2Houston Dynam | 2 - 1 | Austin FC IIAustin FC II |
| 27 Apr 25 | r10 | Huntsville CityHuntsville Ci | 4 - 0 | Inter Miami IIInter Miami I |
| 27 Apr 25 | r10 | Orlando City BOrlando City | 2 - 4 | New York Red Bulls IINew York Red |
| 28 Apr 25 | r10 | The Town FCThe Town FC | 5 - 1 | Los Angeles FC IILos Angeles F |
| 28 Apr 25 | r10 | Whitecaps FC 2Whitecaps FC | 2 - 3 | Ventura CountyVentura Count |
| 02 May 25 | r10 | Minnesota United FC 2Minnesota Uni | 0 - 1 | North Texas SCNorth Texas S |
| 03 May 25 | r10 | Chicago Fire IIChicago Fire | 5 - 1 | Orlando City BOrlando City |
| 03 May 25 | r10 | Austin FC IIAustin FC II | 0 - 0 | Sporting Kansas City IISporting Kans |
| |
| 03 May 25 | r11 | Ventura CountyVentura Count | 1 - 2 | Tacoma DefianceTacoma Defian |
| |
| 03 May 25 | r10 | Whitecaps FC 2Whitecaps FC | 1 - 1 | Real MonarchsReal Monarchs |
| |
| 03 May 25 | r11 | Chattanooga FCChattanooga F | 0 - 0 | Philadelphia Union IIPhiladelphia |
| 04 May 25 | r11 | Huntsville CityHuntsville Ci | 2 - 2 | Atlanta United IIAtlanta Unite |
| 04 May 25 | r11 | Toronto FC IIToronto FC II | 3 - 3 | New England Revolution IINew England R |
| 04 May 25 | r11 | New York Red Bulls IINew York Red | 2 - 2 | Carolina CoreCarolina Core |
| 04 May 25 | r11 | St. Louis City SC 2St. Louis Cit | 3 - 1 | Houston Dynamo 2Houston Dynam |
| 04 May 25 | r11 | Inter Miami IIInter Miami I | 4 - 2 | New York City FC IINew York City |
| 05 May 25 | r11 | The Town FCThe Town FC | 5 - 0 | Portland Timbers IIPortland Timb |
| 05 May 25 | r11 | Los Angeles FC IILos Angeles F | 3 - 2 | Colorado Rapids 2Colorado Rapi |
| |
| 09 May 25 | r12 | Chicago Fire IIChicago Fire | 2 - 1 | FC Cincinnati 2FC Cincinnati |
| |
| 09 May 25 | r11 | Portland Timbers IIPortland Timb | 1 - 0 | Whitecaps FC 2Whitecaps FC |
| |
| 09 May 25 | r12 | Crown LegacyCrown Legacy | 4 - 2 | Inter Miami IIInter Miami I |
| 09 May 25 | r12 | Houston Dynamo 2Houston Dynam | 0 - 0 | Colorado Rapids 2Colorado Rapi |
| 09 May 25 | r12 | Toronto FC IIToronto FC II | 1 - 2 | Chattanooga FCChattanooga F |
| 09 May 25 | r12 | New York City FC IINew York City | 5 - 2 | New York Red Bulls IINew York Red |
| 10 May 25 | r12 | Ventura CountyVentura Count | 2 - 1 | Los Angeles FC IILos Angeles F |
| 10 May 25 | r12 | Carolina CoreCarolina Core | 0 - 0 | Huntsville CityHuntsville Ci |
| 11 May 25 | r12 | Philadelphia Union IIPhiladelphia | 3 - 0 | Columbus Crew 2Columbus Crew |
| 12 May 25 | r12 | The Town FCThe Town FC | 4 - 0 | St. Louis City SC 2St. Louis Cit |
| 14 May 25 | r12 | Ventura CountyVentura Count | 0 - 1 | Austin FC IIAustin FC II |
| |
| 15 May 25 | r13 | Whitecaps FC 2Whitecaps FC | 5 - 0 | Tacoma DefianceTacoma Defian |
| 15 May 25 | r13 | Portland Timbers IIPortland Timb | 3 - 0 | Los Angeles FC IILos Angeles F |
| 15 May 25 | r13 | New York City FC IINew York City | 3 - 0 | Toronto FC IIToronto FC II |
| 17 May 25 | r13 | Orlando City BOrlando City | 3 - 0 | Inter Miami IIInter Miami I |
| 18 May 25 | r13 | Huntsville CityHuntsville Ci | 1 - 2 | Chattanooga FCChattanooga F |
| 18 May 25 | r13 | Sporting Kansas City IISporting Kans | 0 - 0 | The Town FCThe Town FC |
| 18 May 25 | r13 | Columbus Crew 2Columbus Crew | 1 - 0 | FC Cincinnati 2FC Cincinnati |
| 18 May 25 | r13 | Minnesota United FC 2Minnesota Uni | 2 - 3 | St. Louis City SC 2St. Louis Cit |
| 18 May 25 | r13 | New York Red Bulls IINew York Red | 4 - 1 | New England Revolution IINew England R |
| |
| 18 May 25 | r14 | Whitecaps FC 2Whitecaps FC | 0 - 2 | Ventura CountyVentura Count |
| |
| 19 May 25 | r03 | Colorado Rapids 2Colorado Rapi | 2 - 1 | Real MonarchsReal Monarchs |
| |
| 19 May 25 | r14 | North Texas SCNorth Texas S | 2 - 1 | Houston Dynamo 2Houston Dynam |
| 19 May 25 | r14 | Portland Timbers IIPortland Timb | 2 - 1 | Tacoma DefianceTacoma Defian |
| 19 May 25 | r14 | Atlanta United IIAtlanta Unite | 2 - 2 | Crown LegacyCrown Legacy |
| 23 May 25 | r14 | New York City FC IINew York City | 2 - 2 | Chicago Fire IIChicago Fire |
| 23 May 25 | r14 | Sporting Kansas City IISporting Kans | 0 - 3 | Los Angeles FC IILos Angeles F |
| 23 May 25 | r14 | Toronto FC IIToronto FC II | 1 - 2 | Huntsville CityHuntsville Ci |
| 24 May 25 | r14 | St. Louis City SC 2St. Louis Cit | 6 - 3 | Portland Timbers IIPortland Timb |
| 24 May 25 | r14 | Austin FC IIAustin FC II | 1 - 1 | Minnesota United FC 2Minnesota Uni |
| |
| 24 May 25 | r15 | Chattanooga FCChattanooga F | 1 - 0 | New England Revolution IINew England R |
| |
| 25 May 25 | r03 | Philadelphia Union IIPhiladelphia | 0 - 1 | Inter Miami IIInter Miami I |
| |
| 25 May 25 | r15 | Columbus Crew 2Columbus Crew | 0 - 1 | New York Red Bulls IINew York Red |
| |
| 25 May 25 | r14 | Atlanta United IIAtlanta Unite | 3 - 0 | Orlando City BOrlando City |
| |
| 25 May 25 | r15 | Crown LegacyCrown Legacy | 2 - 0 | FC Cincinnati 2FC Cincinnati |
| 26 May 25 | r15 | Colorado Rapids 2Colorado Rapi | 0 - 3 | The Town FCThe Town FC |
| 26 May 25 | r15 | Tacoma DefianceTacoma Defian | 2 - 3 | North Texas SCNorth Texas S |
| 29 May 25 | r15 | Real MonarchsReal Monarchs | 4 - 1 | Portland Timbers IIPortland Timb |
| 29 May 25 | r15 | Minnesota United FC 2Minnesota Uni | 2 - 3 | Whitecaps FC 2Whitecaps FC |
| 30 May 25 | r15 | New York Red Bulls IINew York Red | 1 - 0 | Atlanta United IIAtlanta Unite |
| 30 May 25 | r15 | Toronto FC IIToronto FC II | 1 - 0 | Crown LegacyCrown Legacy |
| 31 May 25 | r15 | Austin FC IIAustin FC II | 1 - 1 | Houston Dynamo 2Houston Dynam |
| |
| 31 May 25 | r16 | New York City FC IINew York City | 0 - 1 | New England Revolution IINew England R |
| 01 Jun 25 | r16 | Tacoma DefianceTacoma Defian | 1 - 1 | Minnesota United FC 2Minnesota Uni |
| 01 Jun 25 | r16 | Sporting Kansas City IISporting Kans | 1 - 4 | Colorado Rapids 2Colorado Rapi |
| 01 Jun 25 | r16 | Chicago Fire IIChicago Fire | 5 - 0 | Columbus Crew 2Columbus Crew |
| 01 Jun 25 | r16 | Inter Miami IIInter Miami I | 1 - 2 | Carolina CoreCarolina Core |
| 01 Jun 25 | r16 | Orlando City BOrlando City | 2 - 1 | Chattanooga FCChattanooga F |
| 02 Jun 25 | r16 | Los Angeles FC IILos Angeles F | 1 - 2 | The Town FCThe Town FC |
| 02 Jun 25 | r16 | Ventura CountyVentura Count | 3 - 3 | Real MonarchsReal Monarchs |
| 03 Jun 25 | r16 | FC Cincinnati 2FC Cincinnati | 1 - 4 | Philadelphia Union IIPhiladelphia |
| 04 Jun 25 | r16 | Crown LegacyCrown Legacy | 2 - 5 | New York Red Bulls IINew York Red |
| |
| 05 Jun 25 | r17 | St. Louis City SC 2St. Louis Cit | 2 - 0 | North Texas SCNorth Texas S |
| 06 Jun 25 | r17 | Atlanta United IIAtlanta Unite | 2 - 3 | New York City FC IINew York City |
| 07 Jun 25 | r17 | Huntsville CityHuntsville Ci | 2 - 3 | Orlando City BOrlando City |
| 07 Jun 25 | r17 | Chattanooga FCChattanooga F | 3 - 3 | Inter Miami IIInter Miami I |
| 08 Jun 25 | r17 | Houston Dynamo 2Houston Dynam | 1 - 1 | Sporting Kansas City IISporting Kans |
| 08 Jun 25 | r17 | FC Cincinnati 2FC Cincinnati | 1 - 1 | Toronto FC IIToronto FC II |
| 09 Jun 25 | r17 | Colorado Rapids 2Colorado Rapi | 1 - 0 | Austin FC IIAustin FC II |
| |
| 09 Jun 25 | r06 | Chicago Fire IIChicago Fire | 2 - 2 | New England Revolution IINew England R |
| |
| 11 Jun 25 | r17 | Atlanta United IIAtlanta Unite | 0 - 1 | Huntsville CityHuntsville Ci |
| 11 Jun 25 | r17 | Carolina CoreCarolina Core | 1 - 0 | Orlando City BOrlando City |
| |
| 12 Jun 25 | r18 | Real MonarchsReal Monarchs | 2 - 1 | Tacoma DefianceTacoma Defian |
| 12 Jun 25 | r18 | Portland Timbers IIPortland Timb | 2 - 3 | Ventura CountyVentura Count |
| 12 Jun 25 | r18 | Columbus Crew 2Columbus Crew | 1 - 1 | New York City FC IINew York City |
| 12 Jun 25 | r18 | Toronto FC IIToronto FC II | 2 - 0 | Inter Miami IIInter Miami I |
| 13 Jun 25 | r18 | Minnesota United FC 2Minnesota Uni | 4 - 1 | Houston Dynamo 2Houston Dynam |
| 13 Jun 25 | r18 | Whitecaps FC 2Whitecaps FC | 2 - 0 | Los Angeles FC IILos Angeles F |
| 14 Jun 25 | r18 | Carolina CoreCarolina Core | 1 - 1 | Chicago Fire IIChicago Fire |
| 15 Jun 25 | r18 | North Texas SCNorth Texas S | 1 - 2 | Austin FC IIAustin FC II |
| 15 Jun 25 | r18 | New England Revolution IINew England R | 0 - 1 | FC Cincinnati 2FC Cincinnati |
| |
| 15 Jun 25 | r19 | New York Red Bulls IINew York Red | 5 - 2 | Chattanooga FCChattanooga F |
| |
| 15 Jun 25 | r18 | Philadelphia Union IIPhiladelphia | 3 - 0 | Crown LegacyCrown Legacy |
| |
| 16 Jun 25 | r19 | Colorado Rapids 2Colorado Rapi | 2 - 3 | St. Louis City SC 2St. Louis Cit |
| 16 Jun 25 | r19 | Minnesota United FC 2Minnesota Uni | 0 - 2 | Ventura CountyVentura Count |
| 16 Jun 25 | r19 | Real MonarchsReal Monarchs | 1 - 1 | Houston Dynamo 2Houston Dynam |
| 19 Jun 25 | r19 | Colorado Rapids 2Colorado Rapi | 1 - 1 | North Texas SCNorth Texas S |
| 21 Jun 25 | r19 | Huntsville CityHuntsville Ci | 3 - 3 | Crown LegacyCrown Legacy |
| 21 Jun 25 | r19 | Portland Timbers IIPortland Timb | 1 - 1 | Austin FC IIAustin FC II |
| 21 Jun 25 | r19 | Columbus Crew 2Columbus Crew | 1 - 3 | Philadelphia Union IIPhiladelphia |
| 21 Jun 25 | r19 | Chattanooga FCChattanooga F | 0 - 0 | FC Cincinnati 2FC Cincinnati |
| |
| 21 Jun 25 | r20 | Whitecaps FC 2Whitecaps FC | 4 - 3 | North Texas SCNorth Texas S |
| 21 Jun 25 | r20 | Carolina CoreCarolina Core | 1 - 2 | New York Red Bulls IINew York Red |
| 22 Jun 25 | r20 | St. Louis City SC 2St. Louis Cit | 3 - 1 | The Town FCThe Town FC |
| 25 Jun 25 | r20 | Inter Miami IIInter Miami I | 1 - 3 | Chicago Fire IIChicago Fire |
| 25 Jun 25 | r20 | Orlando City BOrlando City | 1 - 2 | Toronto FC IIToronto FC II |
| 26 Jun 25 | r20 | Los Angeles FC IILos Angeles F | 1 - 0 | Minnesota United FC 2Minnesota Uni |
| 26 Jun 25 | r20 | Philadelphia Union IIPhiladelphia | 2 - 2 | New England Revolution IINew England R |
| 28 Jun 25 | r20 | Austin FC IIAustin FC II | 1 - 0 | Sporting Kansas City IISporting Kans |
| 28 Jun 25 | r20 | Columbus Crew 2Columbus Crew | 1 - 0 | Carolina CoreCarolina Core |
| |
| 28 Jun 25 | r21 | St. Louis City SC 2St. Louis Cit | 1 - 0 | Houston Dynamo 2Houston Dynam |
| |
| 29 Jun 25 | r20 | Minnesota United FC 2Minnesota Uni | 2 - 1 | Colorado Rapids 2Colorado Rapi |
| |
| 29 Jun 25 | r21 | Los Angeles FC IILos Angeles F | 2 - 3 | Tacoma DefianceTacoma Defian |
| 29 Jun 25 | r21 | New York Red Bulls IINew York Red | 3 - 3 | FC Cincinnati 2FC Cincinnati |
| 29 Jun 25 | r21 | Whitecaps FC 2Whitecaps FC | 2 - 3 | Real MonarchsReal Monarchs |
| 30 Jun 25 | r21 | The Town FCThe Town FC | 1 - 1 | Ventura CountyVentura Count |
| 30 Jun 25 | r21 | Philadelphia Union IIPhiladelphia | 1 - 1 | Orlando City BOrlando City |
| 01 Jul 25 | r21 | Chicago Fire IIChicago Fire | 1 - 1 | Crown LegacyCrown Legacy |
| 04 Jul 25 | r21 | North Texas SCNorth Texas S | 3 - 1 | Minnesota United FC 2Minnesota Uni |
| |
| 04 Jul 25 | r22 | Tacoma DefianceTacoma Defian | 4 - 4 | The Town FCThe Town FC |
| 04 Jul 25 | r22 | Ventura CountyVentura Count | 1 - 2 | Whitecaps FC 2Whitecaps FC |
| 04 Jul 25 | r22 | Carolina CoreCarolina Core | 1 - 2 | Inter Miami IIInter Miami I |
| 05 Jul 25 | r22 | Austin FC IIAustin FC II | 4 - 1 | Los Angeles FC IILos Angeles F |
| 05 Jul 25 | r22 | Sporting Kansas City IISporting Kans | 0 - 4 | Portland Timbers IIPortland Timb |
| 05 Jul 25 | r22 | Columbus Crew 2Columbus Crew | 1 - 2 | New England Revolution IINew England R |
| 05 Jul 25 | r22 | Chattanooga FCChattanooga F | 0 - 1 | Chicago Fire IIChicago Fire |
| 06 Jul 25 | r22 | Philadelphia Union IIPhiladelphia | 5 - 0 | Toronto FC IIToronto FC II |
| 06 Jul 25 | r22 | FC Cincinnati 2FC Cincinnati | 2 - 2 | New York City FC IINew York City |
| 06 Jul 25 | r22 | Crown LegacyCrown Legacy | 2 - 2 | Orlando City BOrlando City |
| |
| 06 Jul 25 | r23 | New York Red Bulls IINew York Red | 1 - 2 | Huntsville CityHuntsville Ci |
| 07 Jul 25 | r23 | Colorado Rapids 2Colorado Rapi | 2 - 1 | Houston Dynamo 2Houston Dynam |
| 07 Jul 25 | r23 | Real MonarchsReal Monarchs | 1 - 3 | St. Louis City SC 2St. Louis Cit |
| 09 Jul 25 | r23 | Crown LegacyCrown Legacy | 0 - 0 | Carolina CoreCarolina Core |
| 09 Jul 25 | r23 | Atlanta United IIAtlanta Unite | 0 - 0 | FC Cincinnati 2FC Cincinnati |
| 11 Jul 25 | r23 | Toronto FC IIToronto FC II | 2 - 2 | New York Red Bulls IINew York Red |
| 12 Jul 25 | r23 | Austin FC IIAustin FC II | 2 - 4 | St. Louis City SC 2St. Louis Cit |
| 13 Jul 25 | r23 | Chicago Fire IIChicago Fire | 3 - 4 | New England Revolution IINew England R |
| 13 Jul 25 | r23 | Philadelphia Union IIPhiladelphia | 3 - 3 | Chattanooga FCChattanooga F |
| 13 Jul 25 | r23 | Minnesota United FC 2Minnesota Uni | 2 - 1 | Real MonarchsReal Monarchs |
| |
| 13 Jul 25 | r24 | FC Cincinnati 2FC Cincinnati | 1 - 0 | Huntsville CityHuntsville Ci |
| 13 Jul 25 | r24 | Inter Miami IIInter Miami I | 3 - 4 | Crown LegacyCrown Legacy |
| 13 Jul 25 | r24 | Orlando City BOrlando City | 3 - 1 | Carolina CoreCarolina Core |
| 13 Jul 25 | r24 | Atlanta United IIAtlanta Unite | 3 - 2 | Columbus Crew 2Columbus Crew |
| 14 Jul 25 | r24 | Colorado Rapids 2Colorado Rapi | 0 - 0 | Whitecaps FC 2Whitecaps FC |
| 14 Jul 25 | r24 | Houston Dynamo 2Houston Dynam | 3 - 0 | North Texas SCNorth Texas S |
| 14 Jul 25 | r24 | The Town FCThe Town FC | 3 - 1 | Sporting Kansas City IISporting Kans |
| 14 Jul 25 | r24 | Los Angeles FC IILos Angeles F | 1 - 0 | Portland Timbers IIPortland Timb |
| 16 Jul 25 | r24 | New York City FC IINew York City | 1 - 0 | Toronto FC IIToronto FC II |
| 17 Jul 25 | r24 | St. Louis City SC 2St. Louis Cit | 1 - 1 | Ventura CountyVentura Count |
| |
| 18 Jul 25 | r25 | Houston Dynamo 2Houston Dynam | 2 - 4 | Whitecaps FC 2Whitecaps FC |
| 18 Jul 25 | r25 | Tacoma DefianceTacoma Defian | 2 - 2 | Real MonarchsReal Monarchs |
| 19 Jul 25 | r25 | Huntsville CityHuntsville Ci | 2 - 1 | Columbus Crew 2Columbus Crew |
| 19 Jul 25 | r25 | Sporting Kansas City IISporting Kans | 1 - 4 | North Texas SCNorth Texas S |
| 19 Jul 25 | r25 | Portland Timbers IIPortland Timb | 1 - 1 | Minnesota United FC 2Minnesota Uni |
| 19 Jul 25 | r25 | Chattanooga FCChattanooga F | 2 - 2 | Inter Miami IIInter Miami I |
| 19 Jul 25 | r25 | Crown LegacyCrown Legacy | 0 - 4 | Philadelphia Union IIPhiladelphia |
| 20 Jul 25 | r25 | Carolina CoreCarolina Core | 1 - 1 | Atlanta United IIAtlanta Unite |
| 20 Jul 25 | r25 | Carolina CoreCarolina Core | 1 - 0 | Atlanta United IIAtlanta Unite |
| 20 Jul 25 | r25 | New England Revolution IINew England R | 3 - 0 | Orlando City BOrlando City |
| 20 Jul 25 | r25 | Toronto FC IIToronto FC II | 2 - 3 | Chicago Fire IIChicago Fire |
| |
| 20 Jul 25 | r26 | New York Red Bulls IINew York Red | 4 - 2 | New York City FC IINew York City |
| 21 Jul 25 | r26 | Real MonarchsReal Monarchs | 1 - 1 | Austin FC IIAustin FC II |
| 21 Jul 25 | r26 | Colorado Rapids 2Colorado Rapi | 6 - 4 | Tacoma DefianceTacoma Defian |
| 21 Jul 25 | r26 | Ventura CountyVentura Count | 3 - 3 | Los Angeles FC IILos Angeles F |
| |
| 23 Jul 25 | r08 | The Town FCThe Town FC | 3 - 2 | Minnesota United FC 2Minnesota Uni |
| |
| 26 Jul 25 | r26 | Huntsville CityHuntsville Ci | 4 - 0 | Orlando City BOrlando City |
| 26 Jul 25 | r26 | Austin FC IIAustin FC II | 2 - 0 | Houston Dynamo 2Houston Dynam |
| 26 Jul 25 | r26 | New York City FC IINew York City | 0 - 2 | Philadelphia Union IIPhiladelphia |
| 26 Jul 25 | r26 | Chattanooga FCChattanooga F | 1 - 3 | Crown LegacyCrown Legacy |
| |
| 27 Jul 25 | r07 | The Town FCThe Town FC | 4 - 0 | Real MonarchsReal Monarchs |
| |
| 27 Jul 25 | r26 | Chicago Fire IIChicago Fire | 9 - 2 | New York Red Bulls IINew York Red |
| 27 Jul 25 | r26 | Columbus Crew 2Columbus Crew | 1 - 2 | Toronto FC IIToronto FC II |
| |
| 27 Jul 25 | r27 | Inter Miami IIInter Miami I | 0 - 3 | FC Cincinnati 2FC Cincinnati |
| 27 Jul 25 | r27 | St. Louis City SC 2St. Louis Cit | 4 - 0 | Minnesota United FC 2Minnesota Uni |
| 28 Jul 25 | r27 | Los Angeles FC IILos Angeles F | 1 - 3 | Sporting Kansas City IISporting Kans |
| 28 Jul 25 | r27 | Tacoma DefianceTacoma Defian | 1 - 2 | Portland Timbers IIPortland Timb |
| 30 Jul 25 | r27 | New England Revolution IINew England R | 3 - 0 | Atlanta United IIAtlanta Unite |
| 30 Jul 25 | r27 | Carolina CoreCarolina Core | 3 - 2 | Philadelphia Union IIPhiladelphia |
| 31 Jul 25 | r27 | Columbus Crew 2Columbus Crew | 1 - 2 | New York Red Bulls IINew York Red |
| 01 Aug 25 | r27 | Whitecaps FC 2Whitecaps FC | 2 - 3 | Sporting Kansas City IISporting Kans |
| 02 Aug 25 | r27 | Tacoma DefianceTacoma Defian | 4 - 6 | Ventura CountyVentura Count |
| |
| 02 Aug 25 | r28 | Crown LegacyCrown Legacy | 0 - 4 | Huntsville CityHuntsville Ci |
| 02 Aug 25 | r28 | Chattanooga FCChattanooga F | 1 - 2 | Toronto FC IIToronto FC II |
| 02 Aug 25 | r28 | Carolina CoreCarolina Core | 1 - 0 | New England Revolution IINew England R |
| 03 Aug 25 | r28 | Minnesota United FC 2Minnesota Uni | 2 - 2 | Houston Dynamo 2Houston Dynam |
| 03 Aug 25 | r28 | North Texas SCNorth Texas S | 1 - 4 | Colorado Rapids 2Colorado Rapi |
| 03 Aug 25 | r28 | Sporting Kansas City IISporting Kans | 1 - 3 | Austin FC IIAustin FC II |
| 03 Aug 25 | r28 | Chicago Fire IIChicago Fire | 6 - 1 | Columbus Crew 2Columbus Crew |
| 03 Aug 25 | r28 | Philadelphia Union IIPhiladelphia | 1 - 0 | FC Cincinnati 2FC Cincinnati |
| |
| 03 Aug 25 | r21 | Inter Miami IIInter Miami I | 2 - 1 | Atlanta United IIAtlanta Unite |
| |
| 03 Aug 25 | r28 | Orlando City BOrlando City | 1 - 4 | New York City FC IINew York City |
| 04 Aug 25 | r28 | Portland Timbers IIPortland Timb | 1 - 2 | Real MonarchsReal Monarchs |
| |
| 04 Aug 25 | r29 | Los Angeles FC IILos Angeles F | 3 - 4 | The Town FCThe Town FC |
| 07 Aug 25 | r29 | Whitecaps FC 2Whitecaps FC | 2 - 4 | St. Louis City SC 2St. Louis Cit |
| 08 Aug 25 | r29 | Toronto FC IIToronto FC II | 1 - 3 | Atlanta United IIAtlanta Unite |
| 08 Aug 25 | r29 | New York City FC IINew York City | 3 - 3 | Chicago Fire IIChicago Fire |
| 09 Aug 25 | r29 | Minnesota United FC 2Minnesota Uni | 3 - 2 | Sporting Kansas City IISporting Kans |
| 09 Aug 25 | r29 | Austin FC IIAustin FC II | 1 - 1 | North Texas SCNorth Texas S |
| 09 Aug 25 | r29 | Orlando City BOrlando City | 2 - 2 | Chattanooga FCChattanooga F |
| 10 Aug 25 | r29 | Houston Dynamo 2Houston Dynam | 0 - 4 | Real MonarchsReal Monarchs |
| |
| 10 Aug 25 | r30 | The Town FCThe Town FC | 2 - 1 | Whitecaps FC 2Whitecaps FC |
| |
| 10 Aug 25 | r29 | Ventura CountyVentura Count | 2 - 2 | Portland Timbers IIPortland Timb |
| |
| 10 Aug 25 | r30 | Huntsville CityHuntsville Ci | 3 - 2 | Carolina CoreCarolina Core |
| 10 Aug 25 | r30 | St. Louis City SC 2St. Louis Cit | 2 - 2 | Colorado Rapids 2Colorado Rapi |
| |
| 11 Aug 25 | r29 | New England Revolution IINew England R | 2 - 2 | Columbus Crew 2Columbus Crew |
| |
| 11 Aug 25 | r30 | Tacoma DefianceTacoma Defian | 4 - 2 | Los Angeles FC IILos Angeles F |
| 11 Aug 25 | r30 | New York Red Bulls IINew York Red | 2 - 0 | Philadelphia Union IIPhiladelphia |
| 11 Aug 25 | r30 | FC Cincinnati 2FC Cincinnati | 4 - 3 | Crown LegacyCrown Legacy |
| 14 Aug 25 | r30 | Inter Miami IIInter Miami I | 2 - 2 | Huntsville CityHuntsville Ci |
| 15 Aug 25 | r30 | New England Revolution IINew England R | 4 - 2 | New York Red Bulls IINew York Red |
| 15 Aug 25 | r30 | Toronto FC IIToronto FC II | 1 - 0 | FC Cincinnati 2FC Cincinnati |
| 16 Aug 25 | r30 | Chicago Fire IIChicago Fire | 2 - 0 | Philadelphia Union IIPhiladelphia |
| |
| 16 Aug 25 | r31 | Minnesota United FC 2Minnesota Uni | 1 - 1 | Tacoma DefianceTacoma Defian |
| 16 Aug 25 | r31 | The Town FCThe Town FC | 4 - 1 | Ventura CountyVentura Count |
| 16 Aug 25 | r31 | Colorado Rapids 2Colorado Rapi | 4 - 1 | Austin FC IIAustin FC II |
| 16 Aug 25 | r31 | Carolina CoreCarolina Core | 0 - 1 | Chattanooga FCChattanooga F |
| 17 Aug 25 | r31 | North Texas SCNorth Texas S | 1 - 3 | St. Louis City SC 2St. Louis Cit |
| 17 Aug 25 | r31 | Sporting Kansas City IISporting Kans | 1 - 3 | Houston Dynamo 2Houston Dynam |
| 17 Aug 25 | r31 | Columbus Crew 2Columbus Crew | 2 - 1 | Orlando City BOrlando City |
| 17 Aug 25 | r31 | Huntsville CityHuntsville Ci | 2 - 1 | New York City FC IINew York City |
| 17 Aug 25 | r31 | Atlanta United IIAtlanta Unite | 1 - 0 | Crown LegacyCrown Legacy |
| 18 Aug 25 | r31 | Real MonarchsReal Monarchs | 0 - 1 | Los Angeles FC IILos Angeles F |
| |
| 20 Aug 25 | r32 | Philadelphia Union IIPhiladelphia | 2 - 2 | Toronto FC IIToronto FC II |
| 21 Aug 25 | r32 | Colorado Rapids 2Colorado Rapi | 1 - 0 | Portland Timbers IIPortland Timb |
| 22 Aug 25 | r32 | Los Angeles FC IILos Angeles F | 1 - 3 | Whitecaps FC 2Whitecaps FC |
| 22 Aug 25 | r32 | Crown LegacyCrown Legacy | 6 - 0 | Inter Miami IIInter Miami I |
| 22 Aug 25 | r32 | New York City FC IINew York City | 3 - 1 | Columbus Crew 2Columbus Crew |
| 23 Aug 25 | r32 | Houston Dynamo 2Houston Dynam | 0 - 1 | The Town FCThe Town FC |
| 23 Aug 25 | r32 | Austin FC IIAustin FC II | 2 - 1 | Ventura CountyVentura Count |
| 23 Aug 25 | r32 | Chattanooga FCChattanooga F | 1 - 0 | Huntsville CityHuntsville Ci |
| 23 Aug 25 | r32 | Orlando City BOrlando City | 2 - 1 | Atlanta United IIAtlanta Unite |
| |
| 24 Aug 25 | r33 | FC Cincinnati 2FC Cincinnati | 2 - 3 | Carolina CoreCarolina Core |
| |
| 24 Aug 25 | r32 | Philadelphia Union IIPhiladelphia | 1 - 3 | New England Revolution IINew England R |
| |
| 24 Aug 25 | r33 | New York Red Bulls IINew York Red | 1 - 0 | Chicago Fire IIChicago Fire |
| 24 Aug 25 | r33 | St. Louis City SC 2St. Louis Cit | 3 - 0 | Sporting Kansas City IISporting Kans |
| 25 Aug 25 | r33 | North Texas SCNorth Texas S | 0 - 4 | Los Angeles FC IILos Angeles F |
| 25 Aug 25 | r33 | Real MonarchsReal Monarchs | 3 - 2 | Minnesota United FC 2Minnesota Uni |
| 25 Aug 25 | r33 | Portland Timbers IIPortland Timb | 2 - 1 | Tacoma DefianceTacoma Defian |
| 27 Aug 25 | r33 | Atlanta United IIAtlanta Unite | 4 - 1 | Inter Miami IIInter Miami I |
| 28 Aug 25 | r33 | The Town FCThe Town FC | 0 - 0 | Real MonarchsReal Monarchs |
| 30 Aug 25 | r33 | Los Angeles FC IILos Angeles F | 1 - 0 | Austin FC IIAustin FC II |
| 30 Aug 25 | r33 | Atlanta United IIAtlanta Unite | 2 - 0 | Huntsville CityHuntsville Ci |
| |
| 31 Aug 25 | r34 | Sporting Kansas City IISporting Kans | 2 - 3 | Colorado Rapids 2Colorado Rapi |
| 31 Aug 25 | r34 | New England Revolution IINew England R | 2 - 2 | Chicago Fire IIChicago Fire |
| 31 Aug 25 | r34 | Toronto FC IIToronto FC II | 3 - 0 | New York City FC IINew York City |
| 31 Aug 25 | r34 | New York Red Bulls IINew York Red | 7 - 4 | Columbus Crew 2Columbus Crew |
| 31 Aug 25 | r34 | Orlando City BOrlando City | 1 - 0 | Crown LegacyCrown Legacy |
| 31 Aug 25 | r34 | Whitecaps FC 2Whitecaps FC | 4 - 1 | Portland Timbers IIPortland Timb |
| 31 Aug 25 | r34 | FC Cincinnati 2FC Cincinnati | 1 - 2 | Philadelphia Union IIPhiladelphia |
| 01 Sep 25 | r34 | Houston Dynamo 2Houston Dynam | 2 - 2 | St. Louis City SC 2St. Louis Cit |
| 01 Sep 25 | r34 | Minnesota United FC 2Minnesota Uni | 1 - 0 | The Town FCThe Town FC |
| 01 Sep 25 | r34 | Real MonarchsReal Monarchs | 3 - 0 | Tacoma DefianceTacoma Defian |
| |
| 01 Sep 25 | r35 | Ventura CountyVentura Count | 0 - 1 | North Texas SCNorth Texas S |
| 04 Sep 25 | r35 | Crown LegacyCrown Legacy | 3 - 4 | Carolina CoreCarolina Core |
| 05 Sep 25 | r35 | Tacoma DefianceTacoma Defian | 1 - 3 | Whitecaps FC 2Whitecaps FC |
| 05 Sep 25 | r35 | Minnesota United FC 2Minnesota Uni | 1 - 0 | Austin FC IIAustin FC II |
| 06 Sep 25 | r35 | Sporting Kansas City IISporting Kans | 2 - 1 | Real MonarchsReal Monarchs |
| 07 Sep 25 | r35 | The Town FCThe Town FC | 2 - 2 | Portland Timbers IIPortland Timb |
| 07 Sep 25 | r35 | North Texas SCNorth Texas S | 1 - 1 | Ventura CountyVentura Count |
| 07 Sep 25 | r35 | Columbus Crew 2Columbus Crew | 4 - 0 | Inter Miami IIInter Miami I |
| |
| 08 Sep 25 | r21 | New England Revolution IINew England R | 1 - 0 | Huntsville CityHuntsville Ci |
| |
| 10 Sep 25 | r35 | Chicago Fire IIChicago Fire | 2 - 1 | FC Cincinnati 2FC Cincinnati |
| 12 Sep 25 | r35 | New England Revolution IINew England R | 2 - 1 | Toronto FC IIToronto FC II |
| |
| 12 Sep 25 | r36 | Crown LegacyCrown Legacy | 2 - 4 | Chattanooga FCChattanooga F |
| 13 Sep 25 | r36 | St. Louis City SC 2St. Louis Cit | 1 - 1 | Minnesota United FC 2Minnesota Uni |
| 13 Sep 25 | r36 | Tacoma DefianceTacoma Defian | 1 - 2 | Austin FC IIAustin FC II |
| 13 Sep 25 | r36 | Whitecaps FC 2Whitecaps FC | 3 - 1 | The Town FCThe Town FC |
| 13 Sep 25 | r36 | Carolina CoreCarolina Core | 4 - 2 | Atlanta United IIAtlanta Unite |
| 14 Sep 25 | r36 | Huntsville CityHuntsville Ci | 2 - 3 | New York Red Bulls IINew York Red |
| 14 Sep 25 | r36 | Columbus Crew 2Columbus Crew | 1 - 3 | Philadelphia Union IIPhiladelphia |
| 14 Sep 25 | r36 | Portland Timbers IIPortland Timb | 5 - 3 | Los Angeles FC IILos Angeles F |
| 14 Sep 25 | r36 | Colorado Rapids 2Colorado Rapi | 0 - 1 | Houston Dynamo 2Houston Dynam |
| 14 Sep 25 | r36 | Inter Miami IIInter Miami I | 1 - 1 | Orlando City BOrlando City |
| |
| 15 Sep 25 | r37 | North Texas SCNorth Texas S | 1 - 1 | Sporting Kansas City IISporting Kans |
| 15 Sep 25 | r37 | Chicago Fire IIChicago Fire | 4 - 5 | New York City FC IINew York City |
| 15 Sep 25 | r37 | Real MonarchsReal Monarchs | 2 - 1 | Ventura CountyVentura Count |
| |
| 18 Sep 25 | r07 | Houston Dynamo 2Houston Dynam | 1 - 2 | Tacoma DefianceTacoma Defian |
| |
| 18 Sep 25 | r37 | New York City FC IINew York City | 1 - 3 | New England Revolution IINew England R |
| 19 Sep 25 | r37 | Sporting Kansas City IISporting Kans | 2 - 2 | Whitecaps FC 2Whitecaps FC |
| 19 Sep 25 | r37 | Toronto FC IIToronto FC II | 0 - 0 | Columbus Crew 2Columbus Crew |
| |
| 20 Sep 25 | r38 | Austin FC IIAustin FC II | 1 - 2 | St. Louis City SC 2St. Louis Cit |
| |
| 20 Sep 25 | r37 | Los Angeles FC IILos Angeles F | 1 - 3 | Real MonarchsReal Monarchs |
| 20 Sep 25 | r37 | Crown LegacyCrown Legacy | 0 - 1 | Atlanta United IIAtlanta Unite |
| 21 Sep 25 | r37 | Philadelphia Union IIPhiladelphia | 5 - 2 | Chicago Fire IIChicago Fire |
| |
| 21 Sep 25 | r38 | Chattanooga FCChattanooga F | 0 - 0 | Carolina CoreCarolina Core |
| |
| 21 Sep 25 | r37 | Minnesota United FC 2Minnesota Uni | 1 - 2 | North Texas SCNorth Texas S |
| |
| 21 Sep 25 | r38 | New York Red Bulls IINew York Red | 1 - 1 | Inter Miami IIInter Miami I |
| 21 Sep 25 | r38 | FC Cincinnati 2FC Cincinnati | 3 - 1 | New England Revolution IINew England R |
| 21 Sep 25 | r38 | Orlando City BOrlando City | 0 - 1 | Huntsville CityHuntsville Ci |
| 22 Sep 25 | r38 | Houston Dynamo 2Houston Dynam | 3 - 1 | Portland Timbers IIPortland Timb |
| 22 Sep 25 | r38 | Tacoma DefianceTacoma Defian | 1 - 4 | Colorado Rapids 2Colorado Rapi |
| 22 Sep 25 | r38 | Ventura CountyVentura Count | 0 - 4 | The Town FCThe Town FC |
| |
| 25 Sep 25 | r07 | FC Cincinnati 2FC Cincinnati | 4 - 3 | Columbus Crew 2Columbus Crew |
| |
| 26 Sep 25 | r38 | New England Revolution IINew England R | 0 - 1 | Crown LegacyCrown Legacy |
| |
| 26 Sep 25 | r39 | Toronto FC IIToronto FC II | 1 - 2 | Philadelphia Union IIPhiladelphia |
| 27 Sep 25 | r39 | Austin FC IIAustin FC II | 1 - 2 | Portland Timbers IIPortland Timb |
| 27 Sep 25 | r39 | Colorado Rapids 2Colorado Rapi | 1 - 2 | Minnesota United FC 2Minnesota Uni |
| 27 Sep 25 | r39 | Carolina CoreCarolina Core | 3 - 3 | Orlando City BOrlando City |
| 28 Sep 25 | r39 | North Texas SCNorth Texas S | 2 - 4 | Real MonarchsReal Monarchs |
| 28 Sep 25 | r39 | Sporting Kansas City IISporting Kans | 1 - 2 | Ventura CountyVentura Count |
| 28 Sep 25 | r39 | Chicago Fire IIChicago Fire | 2 - 5 | Atlanta United IIAtlanta Unite |
| 28 Sep 25 | r39 | St. Louis City SC 2St. Louis Cit | 1 - 1 | Los Angeles FC IILos Angeles F |
| |
| 28 Sep 25 | r40 | The Town FCThe Town FC | 0 - 1 | Tacoma DefianceTacoma Defian |
| |
| 28 Sep 25 | r39 | New York City FC IINew York City | 0 - 1 | Chattanooga FCChattanooga F |
| |
| 29 Sep 25 | r40 | Huntsville CityHuntsville Ci | 4 - 1 | Inter Miami IIInter Miami I |
| |
| 01 Oct 25 | r39 | FC Cincinnati 2FC Cincinnati | 2 - 1 | New York Red Bulls IINew York Red |
| |
| 02 Oct 25 | r17 | The Town FCThe Town FC | 2 - 1 | Whitecaps FC 2Whitecaps FC |
| |
| 02 Oct 25 | r38 | Atlanta United IIAtlanta Unite | 0 - 1 | Chattanooga FCChattanooga F |
| |
| 05 Oct 25 | r40 | Chattanooga FCChattanooga F | 1 - 1 | Atlanta United IIAtlanta Unite |
| 05 Oct 25 | r40 | Columbus Crew 2Columbus Crew | 3 - 3 | Chicago Fire IIChicago Fire |
| 05 Oct 25 | r40 | Huntsville CityHuntsville Ci | 3 - 0 | Carolina CoreCarolina Core |
| 05 Oct 25 | r40 | Inter Miami IIInter Miami I | 2 - 5 | New England Revolution IINew England R |
| 05 Oct 25 | r40 | New York Red Bulls IINew York Red | 2 - 1 | Toronto FC IIToronto FC II |
| 05 Oct 25 | r40 | Orlando City BOrlando City | 1 - 4 | FC Cincinnati 2FC Cincinnati |
| 05 Oct 25 | r40 | Philadelphia Union IIPhiladelphia | 4 - 3 | New York City FC IINew York City |
| 05 Oct 25 | r40 | Los Angeles FC IILos Angeles F | 2 - 4 | North Texas SCNorth Texas S |
| |
| 05 Oct 25 | r41 | Minnesota United FC 2Minnesota Uni | 3 - 1 | Sporting Kansas City IISporting Kans |
| 05 Oct 25 | r41 | Real MonarchsReal Monarchs | 4 - 1 | Whitecaps FC 2Whitecaps FC |
| 05 Oct 25 | r41 | Tacoma DefianceTacoma Defian | 5 - 1 | Houston Dynamo 2Houston Dynam |
| 05 Oct 25 | r41 | Portland Timbers IIPortland Timb | 2 - 1 | St. Louis City SC 2St. Louis Cit |
| 05 Oct 25 | r41 | The Town FCThe Town FC | 1 - 2 | Austin FC IIAustin FC II |
| 05 Oct 25 | r41 | Ventura CountyVentura Count | 0 - 2 | Colorado Rapids 2Colorado Rapi |
| |
| 19 Oct 25 | r16 | Colorado Rapids 2Colorado Rapi | 3 - 2 | Whitecaps FC 2Whitecaps FC |
| 19 Oct 25 | r16 | Philadelphia Union IIPhiladelphia | 2 - 1 | FC Cincinnati 2FC Cincinnati |
| 19 Oct 25 | r16 | New England Revolution IINew England R | 0 - 1 | Chicago Fire IIChicago Fire |
| 19 Oct 25 | r16 | Chattanooga FCChattanooga F | 0 - 2 | Huntsville CityHuntsville Ci |
| 19 Oct 25 | r16 | New York Red Bulls IINew York Red | 5 - 1 | Carolina CoreCarolina Core |
| 19 Oct 25 | r16 | St. Louis City SC 2St. Louis Cit | 3 - 0 | Ventura CountyVentura Count |
| 20 Oct 25 | r16 | Real MonarchsReal Monarchs | 1 - 2 | Minnesota United FC 2Minnesota Uni |
| 20 Oct 25 | r16 | The Town FCThe Town FC | 3 - 0 | North Texas SCNorth Texas S |
| |
| 25 Oct 25 | r00 | Philadelphia Union IIPhiladelphia | 1 - 0 | Huntsville CityHuntsville Ci |
| 26 Oct 25 | r00 | St. Louis City SC 2St. Louis Cit | 0 - 2 | Minnesota United FC 2Minnesota Uni |
| 26 Oct 25 | r00 | New York Red Bulls IINew York Red | 5 - 3 | Chicago Fire IIChicago Fire |
| 27 Oct 25 | r00 | The Town FCThe Town FC | 2 - 4 | Colorado Rapids 2Colorado Rapi |
| 01 Nov 25 | r00 | New York Red Bulls IINew York Red | 2 - 1 | Philadelphia Union IIPhiladelphia |
| 03 Nov 25 | r00 | Colorado Rapids 2Colorado Rapi | 2 - 1 | Minnesota United FC 2Minnesota Uni |
| 09 Nov 25 | r00 | New York Red Bulls IINew York Red | 3 - 3 | Colorado Rapids 2Colorado Rapi |
Team 2025 Schedules
Atlanta United II
Austin FC II
Carolina Core
Chattanooga FC
Chicago Fire II
Colorado Rapids 2
Columbus Crew 2
Connecticut United
Crown Legacy
FC Cincinnati 2
Houston Dynamo 2
Huntsville City
Inter Miami II
Los Angeles FC II
Minnesota United FC 2
New England Revolution II
New York City FC II
New York Red Bulls II
North Texas SC
Orlando City B
Philadelphia Union II
Portland Timbers II
Real Monarchs
San Jose Earthquakes II
Sporting Kansas City II
St. Louis City SC 2
Tacoma Defiance
Toronto FC II
Ventura County
Whitecaps FC 2
League Table
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