| 27 Mar 22 | r01        | Bethlehem SteelBethlehem Ste | 2 - 0 | FC Cincinnati 2FC Cincinnati |
| |
| 05 Apr 22 | r03        | Fort Lauderdale CFFort Lauderda | 3 - 3 | Bethlehem SteelBethlehem Ste |
| 10 Apr 22 | r03        | Bethlehem SteelBethlehem Ste | 0 - 1 | Columbus Crew 2Columbus Crew |
| |
| 30 Apr 22 | r06        | Bethlehem SteelBethlehem Ste | 2 - 1 | New York City FC IINew York City |
| 08 May 22 | r06        | Fort Lauderdale CFFort Lauderda | 1 - 2 | Bethlehem SteelBethlehem Ste |
| |
| 17 May 22 | r08        | Bethlehem SteelBethlehem Ste | 1 - 0 | Orlando City BOrlando City |
| |
| 21 May 22 | r09        | Rochester New York FCRochester New | 3 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 28 May 22 | r10        | New England Revolution IINew England R | 1 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 11 Jun 22 | r12        | Toronto FC IIToronto FC II | 1 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 28 Jun 22 | r14        | Bethlehem SteelBethlehem Ste | 0 - 5 | New York City FC IINew York City |
| |
| 08 Jul 22 | r15        | Rochester New York FCRochester New | 3 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 18 Jul 22 | r17        | Bethlehem SteelBethlehem Ste | 1 - 2 | Toronto FC IIToronto FC II |
| |
| 25 Jul 22 | r18        | Orlando City BOrlando City | 1 - 3 | Bethlehem SteelBethlehem Ste |
| |
| 01 Aug 22 | r19        | Bethlehem SteelBethlehem Ste | 2 - 1 | Columbus Crew 2Columbus Crew |
| |
| 07 Aug 22 | r20        | FC Cincinnati 2FC Cincinnati | 2 - 3 | Bethlehem SteelBethlehem Ste |
| |
| 14 Aug 22 | r21        | Bethlehem SteelBethlehem Ste | 2 - 2 | Fort Lauderdale CFFort Lauderda |
| |
| 22 Aug 22 | r22        | Bethlehem SteelBethlehem Ste | 5 - 1 | New England Revolution IINew England R |
| 24 Aug 22 | r22        | New York City FC IINew York City | 1 - 2 | Bethlehem SteelBethlehem Ste |
| |
| 27 Aug 22 | r15        | Columbus Crew 2Columbus Crew | 2 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 04 Sep 22 | r24        | Bethlehem SteelBethlehem Ste | 1 - 2 | Rochester New York FCRochester New |
| 11 Sep 22 | r24        | Bethlehem SteelBethlehem Ste | 6 - 1 | Orlando City BOrlando City |
| |
| 18 Sep 22 | r25        | New England Revolution IINew England R | 1 - 3 | Bethlehem SteelBethlehem Ste |
| |
| 25 Sep 22 | r00        | Toronto FC IIToronto FC II | 1 - 0 | Bethlehem SteelBethlehem Ste |