| 26 Mar 22 | r01   | St. Louis City SC 2St. Louis Cit | 2 - 0 | Rochester New York FCRochester New |
| 26 Mar 22 | r01 | Fort Lauderdale CFFort Lauderda | 2 - 0 | Columbus Crew 2Columbus Crew |
| 27 Mar 22 | r01 | North Texas SCNorth Texas S | 3 - 1 | Minnesota United FC 2Minnesota Uni |
| 27 Mar 22 | r01 | Houston Dynamo 2Houston Dynam | 1 - 0 | Whitecaps FC 2Whitecaps FC |
| 27 Mar 22 | r01 | Bethlehem SteelBethlehem Ste | 2 - 0 | FC Cincinnati 2FC Cincinnati |
| 27 Mar 22 | r01 | Tacoma DefianceTacoma Defian | 4 - 0 | Real MonarchsReal Monarchs |
| |
| 27 Mar 22 | r02 | New York City FC IINew York City | 2 - 2 | New England Revolution IINew England R |
| 28 Mar 22 | r02 | Colorado Rapids 2Colorado Rapi | 1 - 1 | Swope Park RangersSwope Park Ra |
| 31 Mar 22 | r02 | Portland Timbers IIPortland Timb | 0 - 2 | San Jose Earthquakes IISan Jose Eart |
| 03 Apr 22 | r02 | Tacoma DefianceTacoma Defian | 1 - 1 | North Texas SCNorth Texas S |
| 03 Apr 22 | r02 | FC Cincinnati 2FC Cincinnati | 2 - 1 | Toronto FC IIToronto FC II |
| 03 Apr 22 | r02 | Minnesota United FC 2Minnesota Uni | 0 - 2 | Swope Park RangersSwope Park Ra |
| 03 Apr 22 | r02 | New England Revolution IINew England R | 3 - 1 | Rochester New York FCRochester New |
| 03 Apr 22 | r02 | Orlando City BOrlando City | 2 - 2 | New York City FC IINew York City |
| 04 Apr 22 | r02 | Real MonarchsReal Monarchs | 2 - 2 | Whitecaps FC 2Whitecaps FC |
| |
| 04 Apr 22 | r03 | Houston Dynamo 2Houston Dynam | 1 - 0 | San Jose Earthquakes IISan Jose Eart |
| 05 Apr 22 | r03 | Fort Lauderdale CFFort Lauderda | 3 - 3 | Bethlehem SteelBethlehem Ste |
| 09 Apr 22 | r03 | Real MonarchsReal Monarchs | 2 - 3 | Minnesota United FC 2Minnesota Uni |
| 10 Apr 22 | r03 | Toronto FC IIToronto FC II | 3 - 1 | New York City FC IINew York City |
| 10 Apr 22 | r03 | North Texas SCNorth Texas S | 3 - 1 | Colorado Rapids 2Colorado Rapi |
| 10 Apr 22 | r03 | Bethlehem SteelBethlehem Ste | 0 - 1 | Columbus Crew 2Columbus Crew |
| 10 Apr 22 | r03 | Whitecaps FC 2Whitecaps FC | 2 - 2 | Portland Timbers IIPortland Timb |
| 10 Apr 22 | r03 | Fort Lauderdale CFFort Lauderda | 2 - 0 | Orlando City BOrlando City |
| 11 Apr 22 | r03 | Swope Park RangersSwope Park Ra | 0 - 3 | Houston Dynamo 2Houston Dynam |
| |
| 11 Apr 22 | r04 | St. Louis City SC 2St. Louis Cit | 4 - 3 | Tacoma DefianceTacoma Defian |
| 16 Apr 22 | r04 | Columbus Crew 2Columbus Crew | 2 - 0 | Orlando City BOrlando City |
| 16 Apr 22 | r04 | New York City FC IINew York City | 7 - 0 | Fort Lauderdale CFFort Lauderda |
| 17 Apr 22 | r04 | Swope Park RangersSwope Park Ra | 0 - 1 | St. Louis City SC 2St. Louis Cit |
| 17 Apr 22 | r04 | Houston Dynamo 2Houston Dynam | 4 - 1 | Portland Timbers IIPortland Timb |
| 17 Apr 22 | r04 | Minnesota United FC 2Minnesota Uni | 4 - 0 | Colorado Rapids 2Colorado Rapi |
| 17 Apr 22 | r04 | New England Revolution IINew England R | 3 - 2 | FC Cincinnati 2FC Cincinnati |
| 17 Apr 22 | r04 | Tacoma DefianceTacoma Defian | 1 - 2 | Whitecaps FC 2Whitecaps FC |
| 18 Apr 22 | r04 | San Jose Earthquakes IISan Jose Eart | 0 - 1 | North Texas SCNorth Texas S |
| |
| 23 Apr 22 | r05 | FC Cincinnati 2FC Cincinnati | 0 - 1 | Fort Lauderdale CFFort Lauderda |
| 23 Apr 22 | r05 | North Texas SCNorth Texas S | 2 - 3 | Houston Dynamo 2Houston Dynam |
| 24 Apr 22 | r05 | Rochester New York FCRochester New | 2 - 3 | New York City FC IINew York City |
| 24 Apr 22 | r05 | Columbus Crew 2Columbus Crew | 2 - 1 | Toronto FC IIToronto FC II |
| 25 Apr 22 | r05 | Orlando City BOrlando City | 0 - 0 | New England Revolution IINew England R |
| 25 Apr 22 | r05 | Whitecaps FC 2Whitecaps FC | 4 - 1 | Swope Park RangersSwope Park Ra |
| 25 Apr 22 | r05 | St. Louis City SC 2St. Louis Cit | 0 - 4 | Minnesota United FC 2Minnesota Uni |
| 25 Apr 22 | r05 | Portland Timbers IIPortland Timb | 1 - 1 | Real MonarchsReal Monarchs |
| 26 Apr 22 | r05 | San Jose Earthquakes IISan Jose Eart | 2 - 2 | Tacoma DefianceTacoma Defian |
| |
| 30 Apr 22 | r06 | Real MonarchsReal Monarchs | 0 - 2 | St. Louis City SC 2St. Louis Cit |
| 30 Apr 22 | r06 | Bethlehem SteelBethlehem Ste | 2 - 1 | New York City FC IINew York City |
| 30 Apr 22 | r06 | Whitecaps FC 2Whitecaps FC | 2 - 0 | San Jose Earthquakes IISan Jose Eart |
| 30 Apr 22 | r06 | Toronto FC IIToronto FC II | 4 - 2 | FC Cincinnati 2FC Cincinnati |
| 01 May 22 | r06 | New England Revolution IINew England R | 1 - 0 | Fort Lauderdale CFFort Lauderda |
| 01 May 22 | r06 | Colorado Rapids 2Colorado Rapi | 3 - 1 | Portland Timbers IIPortland Timb |
| 01 May 22 | r06 | Tacoma DefianceTacoma Defian | 4 - 1 | Houston Dynamo 2Houston Dynam |
| 02 May 22 | r06 | Swope Park RangersSwope Park Ra | 0 - 2 | North Texas SCNorth Texas S |
| 08 May 22 | r06 | Fort Lauderdale CFFort Lauderda | 1 - 2 | Bethlehem SteelBethlehem Ste |
| |
| 08 May 22 | r07 | St. Louis City SC 2St. Louis Cit | 1 - 2 | Whitecaps FC 2Whitecaps FC |
| 08 May 22 | r07 | Swope Park RangersSwope Park Ra | 4 - 2 | Real MonarchsReal Monarchs |
| 08 May 22 | r07 | New York City FC IINew York City | 4 - 1 | Toronto FC IIToronto FC II |
| 08 May 22 | r07 | New England Revolution IINew England R | 0 - 4 | Columbus Crew 2Columbus Crew |
| 08 May 22 | r07 | FC Cincinnati 2FC Cincinnati | 1 - 2 | Rochester New York FCRochester New |
| 08 May 22 | r07 | San Jose Earthquakes IISan Jose Eart | 3 - 0 | Portland Timbers IIPortland Timb |
| 08 May 22 | r07 | North Texas SCNorth Texas S | 1 - 1 | Tacoma DefianceTacoma Defian |
| 09 May 22 | r07 | Houston Dynamo 2Houston Dynam | 2 - 0 | Colorado Rapids 2Colorado Rapi |
| 14 May 22 | r07  | Minnesota United FC 2Minnesota Uni | 1 - 1 | Houston Dynamo 2Houston Dynam |
| |
| 14 May 22 | r08 | Rochester New York FCRochester New | 4 - 1 | Fort Lauderdale CFFort Lauderda |
| 14 May 22 | r08 | Toronto FC IIToronto FC II | 0 - 1 | New England Revolution IINew England R |
| 15 May 22 | r08 | North Texas SCNorth Texas S | 1 - 0 | Whitecaps FC 2Whitecaps FC |
| 15 May 22 | r08 | New York City FC IINew York City | 0 - 1 | Columbus Crew 2Columbus Crew |
| 16 May 22 | r08 | Portland Timbers IIPortland Timb | 1 - 2 | Swope Park RangersSwope Park Ra |
| 16 May 22 | r08 | Tacoma DefianceTacoma Defian | 2 - 0 | Real MonarchsReal Monarchs |
| 16 May 22 | r08 | San Jose Earthquakes IISan Jose Eart | 7 - 1 | Colorado Rapids 2Colorado Rapi |
| 17 May 22 | r08 | Bethlehem SteelBethlehem Ste | 1 - 0 | Orlando City BOrlando City |
| 21 May 22 | r08 | Real MonarchsReal Monarchs | 0 - 3 | North Texas SCNorth Texas S |
| |
| 21 May 22 | r09 | San Jose Earthquakes IISan Jose Eart | 1 - 2 | Swope Park RangersSwope Park Ra |
| 21 May 22 | r09 | Orlando City BOrlando City | 6 - 0 | Fort Lauderdale CFFort Lauderda |
| 21 May 22 | r09 | Rochester New York FCRochester New | 3 - 0 | Bethlehem SteelBethlehem Ste |
| 21 May 22 | r09 | Whitecaps FC 2Whitecaps FC | 2 - 2 | Minnesota United FC 2Minnesota Uni |
| 22 May 22 | r09 | Columbus Crew 2Columbus Crew | 4 - 2 | Toronto FC IIToronto FC II |
| 22 May 22 | r09 | FC Cincinnati 2FC Cincinnati | 0 - 1 | New England Revolution IINew England R |
| 23 May 22 | r09 | St. Louis City SC 2St. Louis Cit | 3 - 1 | Portland Timbers IIPortland Timb |
| 23 May 22 | r09 | Colorado Rapids 2Colorado Rapi | 0 - 2 | Tacoma DefianceTacoma Defian |
| 26 May 22 | r09 | Real MonarchsReal Monarchs | 0 - 1 | Houston Dynamo 2Houston Dynam |
| |
| 28 May 22 | r10 | New England Revolution IINew England R | 1 - 0 | Bethlehem SteelBethlehem Ste |
| 29 May 22 | r10 | Columbus Crew 2Columbus Crew | 0 - 4 | Rochester New York FCRochester New |
| 29 May 22 | r10 | Swope Park RangersSwope Park Ra | 1 - 1 | Whitecaps FC 2Whitecaps FC |
| 29 May 22 | r10 | Minnesota United FC 2Minnesota Uni | 5 - 1 | Colorado Rapids 2Colorado Rapi |
| 30 May 22 | r10 | Fort Lauderdale CFFort Lauderda | 1 - 2 | New York City FC IINew York City |
| 30 May 22 | r10 | Orlando City BOrlando City | 3 - 5 | FC Cincinnati 2FC Cincinnati |
| 30 May 22 | r10 | St. Louis City SC 2St. Louis Cit | 1 - 1 | San Jose Earthquakes IISan Jose Eart |
| 01 Jun 22 | r10 | Tacoma DefianceTacoma Defian | 3 - 0 | Portland Timbers IIPortland Timb |
| 03 Jun 22 | r10 | Rochester New York FCRochester New | 1 - 1 | Toronto FC IIToronto FC II |
| |
| 04 Jun 22 | r11 | Colorado Rapids 2Colorado Rapi | 1 - 3 | North Texas SCNorth Texas S |
| 05 Jun 22 | r11 | Fort Lauderdale CFFort Lauderda | 2 - 0 | New England Revolution IINew England R |
| 05 Jun 22 | r11 | Orlando City BOrlando City | 1 - 1 | New York City FC IINew York City |
| 05 Jun 22 | r11 | Swope Park RangersSwope Park Ra | 1 - 2 | Minnesota United FC 2Minnesota Uni |
| 05 Jun 22 | r11 | St. Louis City SC 2St. Louis Cit | 2 - 0 | Houston Dynamo 2Houston Dynam |
| 05 Jun 22 | r11 | Tacoma DefianceTacoma Defian | 6 - 1 | San Jose Earthquakes IISan Jose Eart |
| 06 Jun 22 | r11 | Whitecaps FC 2Whitecaps FC | 4 - 0 | Real MonarchsReal Monarchs |
| 09 Jun 22 | r11 | Colorado Rapids 2Colorado Rapi | 2 - 2 | St. Louis City SC 2St. Louis Cit |
| 09 Jun 22 | r11 | San Jose Earthquakes IISan Jose Eart | 2 - 1 | Minnesota United FC 2Minnesota Uni |
| |
| 10 Jun 22 | r12 | Columbus Crew 2Columbus Crew | 5 - 0 | Fort Lauderdale CFFort Lauderda |
| 11 Jun 22 | r12 | Houston Dynamo 2Houston Dynam | 0 - 1 | Swope Park RangersSwope Park Ra |
| 11 Jun 22 | r12 | Toronto FC IIToronto FC II | 1 - 0 | Bethlehem SteelBethlehem Ste |
| 12 Jun 22 | r12 | FC Cincinnati 2FC Cincinnati | 1 - 0 | Rochester New York FCRochester New |
| 12 Jun 22 | r12 | New England Revolution IINew England R | 2 - 1 | Orlando City BOrlando City |
| 12 Jun 22 | r12 | North Texas SCNorth Texas S | 2 - 1 | Portland Timbers IIPortland Timb |
| 12 Jun 22 | r12 | Whitecaps FC 2Whitecaps FC | 2 - 2 | Tacoma DefianceTacoma Defian |
| 13 Jun 22 | r12 | Colorado Rapids 2Colorado Rapi | 3 - 1 | Real MonarchsReal Monarchs |
| 18 Jun 22 | r12 | Swope Park RangersSwope Park Ra | 1 - 2 | St. Louis City SC 2St. Louis Cit |
| |
| 18 Jun 22 | r13 | Real MonarchsReal Monarchs | 0 - 1 | San Jose Earthquakes IISan Jose Eart |
| 18 Jun 22 | r13 | Whitecaps FC 2Whitecaps FC | 3 - 1 | North Texas SCNorth Texas S |
| 18 Jun 22 | r13 | New York City FC IINew York City | 0 - 2 | Toronto FC IIToronto FC II |
| 19 Jun 22 | r13 | New England Revolution IINew England R | 1 - 1 | Rochester New York FCRochester New |
| 19 Jun 22 | r13 | Tacoma DefianceTacoma Defian | 4 - 1 | Colorado Rapids 2Colorado Rapi |
| 19 Jun 22 | r13 | Columbus Crew 2Columbus Crew | 6 - 1 | Orlando City BOrlando City |
| 20 Jun 22 | r13 | Fort Lauderdale CFFort Lauderda | 4 - 0 | FC Cincinnati 2FC Cincinnati |
| 20 Jun 22 | r13 | Portland Timbers IIPortland Timb | 2 - 1 | Houston Dynamo 2Houston Dynam |
| 25 Jun 22 | r13 | Rochester New York FCRochester New | 0 - 0 | Columbus Crew 2Columbus Crew |
| |
| 25 Jun 22 | r14 | Whitecaps FC 2Whitecaps FC | 2 - 3 | San Jose Earthquakes IISan Jose Eart |
| 25 Jun 22 | r14 | FC Cincinnati 2FC Cincinnati | 1 - 3 | Orlando City BOrlando City |
| 26 Jun 22 | r14 | St. Louis City SC 2St. Louis Cit | 2 - 0 | Real MonarchsReal Monarchs |
| 27 Jun 22 | r14 | Houston Dynamo 2Houston Dynam | 1 - 0 | Tacoma DefianceTacoma Defian |
| 27 Jun 22 | r14 | North Texas SCNorth Texas S | 4 - 0 | Minnesota United FC 2Minnesota Uni |
| 27 Jun 22 | r14 | Portland Timbers IIPortland Timb | 2 - 4 | Colorado Rapids 2Colorado Rapi |
| 28 Jun 22 | r14 | Bethlehem SteelBethlehem Ste | 0 - 5 | New York City FC IINew York City |
| |
| 02 Jul 22 | r06 | Rochester New York FCRochester New | 3 - 2 | Orlando City BOrlando City |
| |
| 02 Jul 22 | r14 | Real MonarchsReal Monarchs | 4 - 0 | Portland Timbers IIPortland Timb |
| |
| 02 Jul 22 | r15 | San Jose Earthquakes IISan Jose Eart | 1 - 1 | Houston Dynamo 2Houston Dynam |
| 03 Jul 22 | r15 | New York City FC IINew York City | 5 - 1 | FC Cincinnati 2FC Cincinnati |
| 03 Jul 22 | r15 | Swope Park RangersSwope Park Ra | 4 - 2 | North Texas SCNorth Texas S |
| 03 Jul 22 | r15 | St. Louis City SC 2St. Louis Cit | 1 - 2 | Colorado Rapids 2Colorado Rapi |
| 03 Jul 22 | r15 | Minnesota United FC 2Minnesota Uni | 2 - 0 | Whitecaps FC 2Whitecaps FC |
| 04 Jul 22 | r15 | Toronto FC IIToronto FC II | 1 - 1 | New England Revolution IINew England R |
| 08 Jul 22 | r15 | Rochester New York FCRochester New | 3 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 10 Jul 22 | r16 | New England Revolution IINew England R | 0 - 4 | New York City FC IINew York City |
| 11 Jul 22 | r16 | Orlando City BOrlando City | 1 - 3 | Fort Lauderdale CFFort Lauderda |
| 11 Jul 22 | r16 | Toronto FC IIToronto FC II | 0 - 0 | Columbus Crew 2Columbus Crew |
| 11 Jul 22 | r16 | Colorado Rapids 2Colorado Rapi | 0 - 2 | Swope Park RangersSwope Park Ra |
| 11 Jul 22 | r16 | Houston Dynamo 2Houston Dynam | 4 - 1 | Real MonarchsReal Monarchs |
| 11 Jul 22 | r16 | North Texas SCNorth Texas S | 1 - 3 | San Jose Earthquakes IISan Jose Eart |
| 11 Jul 22 | r16 | Minnesota United FC 2Minnesota Uni | 1 - 2 | St. Louis City SC 2St. Louis Cit |
| 11 Jul 22 | r16 | Portland Timbers IIPortland Timb | 1 - 6 | Tacoma DefianceTacoma Defian |
| 15 Jul 22 | r16 | Colorado Rapids 2Colorado Rapi | 2 - 1 | San Jose Earthquakes IISan Jose Eart |
| 16 Jul 22 | r16 | North Texas SCNorth Texas S | 3 - 3 | Houston Dynamo 2Houston Dynam |
| |
| 17 Jul 22 | r17 | Columbus Crew 2Columbus Crew | 4 - 0 | FC Cincinnati 2FC Cincinnati |
| 17 Jul 22 | r17 | New York City FC IINew York City | 0 - 1 | Rochester New York FCRochester New |
| 17 Jul 22 | r17 | Real MonarchsReal Monarchs | 1 - 0 | Swope Park RangersSwope Park Ra |
| 17 Jul 22 | r17 | Portland Timbers IIPortland Timb | 1 - 2 | Whitecaps FC 2Whitecaps FC |
| 18 Jul 22 | r17 | Tacoma DefianceTacoma Defian | 3 - 2 | Minnesota United FC 2Minnesota Uni |
| 18 Jul 22 | r17 | Bethlehem SteelBethlehem Ste | 1 - 2 | Toronto FC IIToronto FC II |
| 22 Jul 22 | r17 | Portland Timbers IIPortland Timb | 1 - 2 | San Jose Earthquakes IISan Jose Eart |
| 22 Jul 22 | r17 | Rochester New York FCRochester New | 0 - 2 | FC Cincinnati 2FC Cincinnati |
| 23 Jul 22 | r17 | Swope Park RangersSwope Park Ra | 0 - 3 | Tacoma DefianceTacoma Defian |
| |
| 23 Jul 22 | r18 | St. Louis City SC 2St. Louis Cit | 2 - 0 | North Texas SCNorth Texas S |
| 24 Jul 22 | r18 | Columbus Crew 2Columbus Crew | 4 - 1 | New England Revolution IINew England R |
| 24 Jul 22 | r18 | New York City FC IINew York City | 2 - 2 | Fort Lauderdale CFFort Lauderda |
| 25 Jul 22 | r18 | Orlando City BOrlando City | 1 - 3 | Bethlehem SteelBethlehem Ste |
| 25 Jul 22 | r18 | Colorado Rapids 2Colorado Rapi | 2 - 2 | Whitecaps FC 2Whitecaps FC |
| 25 Jul 22 | r18 | Houston Dynamo 2Houston Dynam | 1 - 0 | Minnesota United FC 2Minnesota Uni |
| 30 Jul 22 | r18 | Whitecaps FC 2Whitecaps FC | 2 - 2 | Houston Dynamo 2Houston Dynam |
| 31 Jul 22 | r18 | Tacoma DefianceTacoma Defian | 5 - 1 | St. Louis City SC 2St. Louis Cit |
| 31 Jul 22 | r18 | FC Cincinnati 2FC Cincinnati | 1 - 1 | Fort Lauderdale CFFort Lauderda |
| |
| 31 Jul 22 | r19 | Minnesota United FC 2Minnesota Uni | 3 - 1 | Portland Timbers IIPortland Timb |
| 01 Aug 22 | r19 | New England Revolution IINew England R | 0 - 2 | Toronto FC IIToronto FC II |
| 01 Aug 22 | r19 | Bethlehem SteelBethlehem Ste | 2 - 1 | Columbus Crew 2Columbus Crew |
| 01 Aug 22 | r19 | North Texas SCNorth Texas S | 3 - 0 | Swope Park RangersSwope Park Ra |
| 01 Aug 22 | r19 | San Jose Earthquakes IISan Jose Eart | 3 - 1 | Real MonarchsReal Monarchs |
| 06 Aug 22 | r19 | Real MonarchsReal Monarchs | 3 - 1 | Whitecaps FC 2Whitecaps FC |
| 06 Aug 22 | r19 | San Jose Earthquakes IISan Jose Eart | 0 - 2 | Tacoma DefianceTacoma Defian |
| 07 Aug 22 | r19 | Colorado Rapids 2Colorado Rapi | 3 - 3 | Minnesota United FC 2Minnesota Uni |
| 07 Aug 22 | r19 | Columbus Crew 2Columbus Crew | 3 - 0 | New York City FC IINew York City |
| |
| 07 Aug 22 | r20 | FC Cincinnati 2FC Cincinnati | 2 - 3 | Bethlehem SteelBethlehem Ste |
| 08 Aug 22 | r20 | Fort Lauderdale CFFort Lauderda | 4 - 2 | New England Revolution IINew England R |
| 08 Aug 22 | r20 | Toronto FC IIToronto FC II | 3 - 0 | Orlando City BOrlando City |
| 08 Aug 22 | r20 | Houston Dynamo 2Houston Dynam | 3 - 0 | Swope Park RangersSwope Park Ra |
| 08 Aug 22 | r20 | Portland Timbers IIPortland Timb | 2 - 2 | North Texas SCNorth Texas S |
| 13 Aug 22 | r20 | Rochester New York FCRochester New | 1 - 2 | Toronto FC IIToronto FC II |
| 13 Aug 22 | r20 | New York City FC IINew York City | 0 - 2 | Orlando City BOrlando City |
| 13 Aug 22 | r20 | North Texas SCNorth Texas S | 4 - 0 | Real MonarchsReal Monarchs |
| 14 Aug 22 | r20 | Whitecaps FC 2Whitecaps FC | 1 - 4 | St. Louis City SC 2St. Louis Cit |
| 14 Aug 22 | r20 | FC Cincinnati 2FC Cincinnati | 3 - 3 | Columbus Crew 2Columbus Crew |
| |
| 14 Aug 22 | r21 | Swope Park RangersSwope Park Ra | 2 - 0 | Portland Timbers IIPortland Timb |
| 14 Aug 22 | r21 | Bethlehem SteelBethlehem Ste | 2 - 2 | Fort Lauderdale CFFort Lauderda |
| 15 Aug 22 | r21 | Houston Dynamo 2Houston Dynam | 1 - 1 | Colorado Rapids 2Colorado Rapi |
| 16 Aug 22 | r21 | Minnesota United FC 2Minnesota Uni | 2 - 1 | Tacoma DefianceTacoma Defian |
| 18 Aug 22 | r21 | Orlando City BOrlando City | 5 - 2 | Rochester New York FCRochester New |
| 21 Aug 22 | r21 | Orlando City BOrlando City | 2 - 2 | Columbus Crew 2Columbus Crew |
| 21 Aug 22 | r21 | Tacoma DefianceTacoma Defian | 1 - 0 | Swope Park RangersSwope Park Ra |
| |
| 21 Aug 22 | r22 | Toronto FC IIToronto FC II | 2 - 1 | FC Cincinnati 2FC Cincinnati |
| 22 Aug 22 | r22 | Fort Lauderdale CFFort Lauderda | 2 - 1 | Rochester New York FCRochester New |
| 22 Aug 22 | r22 | Bethlehem SteelBethlehem Ste | 5 - 1 | New England Revolution IINew England R |
| 22 Aug 22 | r22 | Minnesota United FC 2Minnesota Uni | 1 - 1 | Real MonarchsReal Monarchs |
| 22 Aug 22 | r22 | Colorado Rapids 2Colorado Rapi | 1 - 1 | North Texas SCNorth Texas S |
| 22 Aug 22 | r22 | San Jose Earthquakes IISan Jose Eart | 2 - 5 | St. Louis City SC 2St. Louis Cit |
| 24 Aug 22 | r22 | New York City FC IINew York City | 1 - 2 | Bethlehem SteelBethlehem Ste |
| 26 Aug 22 | r22 | Whitecaps FC 2Whitecaps FC | 1 - 2 | Colorado Rapids 2Colorado Rapi |
| 27 Aug 22 | r22 | Real MonarchsReal Monarchs | 1 - 0 | Tacoma DefianceTacoma Defian |
| |
| 27 Aug 22 | r15 | Columbus Crew 2Columbus Crew | 2 - 0 | Bethlehem SteelBethlehem Ste |
| |
| 27 Aug 22 | r23 | Rochester New York FCRochester New | 2 - 0 | New England Revolution IINew England R |
| 28 Aug 22 | r23 | Minnesota United FC 2Minnesota Uni | 0 - 1 | Houston Dynamo 2Houston Dynam |
| 28 Aug 22 | r23 | Portland Timbers IIPortland Timb | 3 - 5 | St. Louis City SC 2St. Louis Cit |
| 28 Aug 22 | r23 | Swope Park RangersSwope Park Ra | 1 - 4 | San Jose Earthquakes IISan Jose Eart |
| 30 Aug 22 | r23 | Orlando City BOrlando City | 2 - 2 | FC Cincinnati 2FC Cincinnati |
| 02 Sep 22 | r23 | New England Revolution IINew England R | 2 - 0 | Orlando City BOrlando City |
| 04 Sep 22 | r23 | Fort Lauderdale CFFort Lauderda | 1 - 4 | Toronto FC IIToronto FC II |
| 04 Sep 22 | r23 | Minnesota United FC 2Minnesota Uni | 1 - 2 | North Texas SCNorth Texas S |
| 04 Sep 22 | r23 | Houston Dynamo 2Houston Dynam | 1 - 0 | St. Louis City SC 2St. Louis Cit |
| 04 Sep 22 | r23 | Real MonarchsReal Monarchs | 4 - 2 | Portland Timbers IIPortland Timb |
| |
| 04 Sep 22 | r24 | Bethlehem SteelBethlehem Ste | 1 - 2 | Rochester New York FCRochester New |
| 06 Sep 22 | r24 | Swope Park RangersSwope Park Ra | 5 - 0 | Colorado Rapids 2Colorado Rapi |
| 06 Sep 22 | r24 | San Jose Earthquakes IISan Jose Eart | 3 - 1 | Whitecaps FC 2Whitecaps FC |
| 10 Sep 22 | r24 | San Jose Earthquakes IISan Jose Eart | 2 - 2 | Real MonarchsReal Monarchs |
| 10 Sep 22 | r24 | Whitecaps FC 2Whitecaps FC | 0 - 1 | Tacoma DefianceTacoma Defian |
| 10 Sep 22 | r24 | New York City FC IINew York City | 0 - 0 | New England Revolution IINew England R |
| 11 Sep 22 | r24 | Bethlehem SteelBethlehem Ste | 6 - 1 | Orlando City BOrlando City |
| |
| 11 Sep 22 | r25 | North Texas SCNorth Texas S | 3 - 1 | St. Louis City SC 2St. Louis Cit |
| 11 Sep 22 | r25 | Toronto FC IIToronto FC II | 0 - 1 | Rochester New York FCRochester New |
| 12 Sep 22 | r25 | Fort Lauderdale CFFort Lauderda | 1 - 1 | Columbus Crew 2Columbus Crew |
| 12 Sep 22 | r25 | Colorado Rapids 2Colorado Rapi | 1 - 0 | Houston Dynamo 2Houston Dynam |
| 12 Sep 22 | r25 | Portland Timbers IIPortland Timb | 2 - 4 | Minnesota United FC 2Minnesota Uni |
| |
| 14 Sep 22 | r24 | FC Cincinnati 2FC Cincinnati | 0 - 4 | New York City FC IINew York City |
| |
| 15 Sep 22 | r14 | Toronto FC IIToronto FC II | 3 - 4 | Fort Lauderdale CFFort Lauderda |
| |
| 15 Sep 22 | r21 | Portland Timbers IIPortland Timb | 2 - 2 | Whitecaps FC 2Whitecaps FC |
| |
| 18 Sep 22 | r25 | Columbus Crew 2Columbus Crew | 9 - 0 | FC Cincinnati 2FC Cincinnati |
| 18 Sep 22 | r25 | New England Revolution IINew England R | 1 - 3 | Bethlehem SteelBethlehem Ste |
| 18 Sep 22 | r25 | Orlando City BOrlando City | 1 - 2 | Toronto FC IIToronto FC II |
| 18 Sep 22 | r25 | Rochester New York FCRochester New | 2 - 2 | New York City FC IINew York City |
| |
| 19 Sep 22 | r26 | Houston Dynamo 2Houston Dynam | 2 - 0 | North Texas SCNorth Texas S |
| 19 Sep 22 | r26 | Minnesota United FC 2Minnesota Uni | 1 - 4 | San Jose Earthquakes IISan Jose Eart |
| 19 Sep 22 | r26 | Real MonarchsReal Monarchs | 2 - 1 | Colorado Rapids 2Colorado Rapi |
| 19 Sep 22 | r26 | Tacoma DefianceTacoma Defian | 0 - 2 | Portland Timbers IIPortland Timb |
| 19 Sep 22 | r26 | St. Louis City SC 2St. Louis Cit | 1 - 1 | Swope Park RangersSwope Park Ra |
| |
| 24 Sep 22 | r00  | Columbus Crew 2Columbus Crew | 4 - 1 | Rochester New York FCRochester New |
| 25 Sep 22 | r00 | Toronto FC IIToronto FC II | 1 - 0 | Bethlehem SteelBethlehem Ste |
| 26 Sep 22 | r00 | St. Louis City SC 2St. Louis Cit | 2 - 0 | North Texas SCNorth Texas S |
| 26 Sep 22 | r00 | Tacoma DefianceTacoma Defian | 2 - 2 | Houston Dynamo 2Houston Dynam |
| 02 Oct 22 | r00 | Columbus Crew 2Columbus Crew | 4 - 3 | Toronto FC IIToronto FC II |
| 03 Oct 22 | r00 | St. Louis City SC 2St. Louis Cit | 2 - 1 | Tacoma DefianceTacoma Defian |
| 08 Oct 22 | r00 | Columbus Crew 2Columbus Crew | 4 - 1 | St. Louis City SC 2St. Louis Cit |
Team 2022 Schedules
Atlanta United II
Austin FC II
Carolina Core
Chattanooga FC
Chicago Fire II
Colorado Rapids 2
Columbus Crew 2
Connecticut United
Crown Legacy
FC Cincinnati 2
Houston Dynamo 2
Huntsville City
Inter Miami II
Los Angeles FC II
Minnesota United FC 2
New England Revolution II
New York City FC II
New York Red Bulls II
North Texas SC
Orlando City B
Philadelphia Union II
Portland Timbers II
Real Monarchs
San Jose Earthquakes II
Sporting Kansas City II
St. Louis City SC 2
Tacoma Defiance
Toronto FC II
Ventura County
Whitecaps FC 2
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