| 06 Nov 21 | r01  | Royal LeopardsRoyal Leopard | 1 - 0 | Mbabane Swallows F.C.Mbabane Swall |
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| 13 Nov 21 | r02 | Milling HotspursMilling Hotsp | 0 - 3 | Royal LeopardsRoyal Leopard |
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| 21 Nov 21 | r03 | Royal LeopardsRoyal Leopard | 5 - 2 | Malanti ChiefsMalanti Chief |
| 24 Nov 21 | r03 | Royal LeopardsRoyal Leopard | 2 - 0 | Rangers FCRangers FC |
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| 07 Dec 21 | r04 | Manzini WanderersManzini Wande | 0 - 0 | Royal LeopardsRoyal Leopard |
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| 11 Dec 21 | r05 | Green Mamba FCGreen Mamba F | 1 - 3 | Royal LeopardsRoyal Leopard |
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| 21 Dec 21 | r06 | Royal LeopardsRoyal Leopard | 2 - 0 | Denver SundownsDenver Sundow |
| 28 Dec 21 | r06 | TambutiTambuti | 0 - 5 | Royal LeopardsRoyal Leopard |
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| 01 Jan 22 | r07 | Moneni PiratesMoneni Pirate | 3 - 2 | Royal LeopardsRoyal Leopard |
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| 09 Jan 22 | r08 | Royal LeopardsRoyal Leopard | 3 - 0 | TinyosiTinyosi |
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| 16 Jan 22 | r09 | Tambankulu CalliesTambankulu Ca | 2 - 1 | Royal LeopardsRoyal Leopard |
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| 31 Jan 22 | r11 | Royal LeopardsRoyal Leopard | 2 - 2 | VovovoVovovo |
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| 10 Feb 22 | r12 | Royal LeopardsRoyal Leopard | 3 - 1 | Young BuffaloesYoung Buffalo |
| 13 Feb 22 | r12 | Manzini Sea BirdsManzini Sea B | 0 - 2 | Royal LeopardsRoyal Leopard |
| 02 Mar 22 | r12 | Royal LeopardsRoyal Leopard | 0 - 2 | Mbabane HighlandersMbabane Highl |
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| 09 Mar 22 | r14 | Royal LeopardsRoyal Leopard | 5 - 0 | Milling HotspursMilling Hotsp |
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| 30 Mar 22 | r15 | Royal LeopardsRoyal Leopard | 2 - 2 | Green Mamba FCGreen Mamba F |
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| 06 Apr 22 | r14 | VovovoVovovo | 2 - 6 | Royal LeopardsRoyal Leopard |
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| 10 Apr 22 | r16 | Rangers FCRangers FC | 0 - 3 | Royal LeopardsRoyal Leopard |
| 13 Apr 22 | r16 | Royal LeopardsRoyal Leopard | 3 - 0 | Moneni PiratesMoneni Pirate |
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| 16 Apr 22 | r17 | Mbabane Swallows F.C.Mbabane Swall | 3 - 2 | Royal LeopardsRoyal Leopard |
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| 19 Apr 22 | r18 | Denver SundownsDenver Sundow | 0 - 0 | Royal LeopardsRoyal Leopard |
| 23 Apr 22 | r18 | Malanti ChiefsMalanti Chief | 0 - 3 | Royal LeopardsRoyal Leopard |
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| 30 Apr 22 | r20 | TinyosiTinyosi | 0 - 3 | Royal LeopardsRoyal Leopard |
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| 04 May 22 | r21 | Royal LeopardsRoyal Leopard | 1 - 0 | Manzini Sea BirdsManzini Sea B |
| 08 May 22 | r21 | Royal LeopardsRoyal Leopard | 3 - 0 | TambutiTambuti |
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| 15 May 22 | r22 | Mbabane HighlandersMbabane Highl | 1 - 1 | Royal LeopardsRoyal Leopard |
| 19 May 22 | r22 | Royal LeopardsRoyal Leopard | 2 - 0 | Tambankulu CalliesTambankulu Ca |
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| 29 May 22 | r23 | Royal LeopardsRoyal Leopard | 2 - 0 | Manzini WanderersManzini Wande |
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| 12 Jun 22 | r25 | Young BuffaloesYoung Buffalo | 0 - 0 | Royal LeopardsRoyal Leopard |
Team 2021-2022 Schedules
Amawele
Ezulwini United
Green Mamba
Malanti Chiefs
Manzini Sea Birds
Manzini Wanderers
Mbabane Highlanders
Mbabane Swallows
Moneni Pirates
Nsingizini Hotspurs
Rangers Shiselweni
Royal Leopards
Sisonkhe
Tabankulu Celtics
Ubombo Sugar
Young Buffaloes
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