| 06 Nov 21 | r01  | Young BuffaloesYoung Buffalo | 1 - 2 | Mbabane HighlandersMbabane Highl |
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| 13 Nov 21 | r02 | Manzini Sea BirdsManzini Sea B | 2 - 0 | Young BuffaloesYoung Buffalo |
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| 21 Nov 21 | r03 | Young BuffaloesYoung Buffalo | 0 - 2 | Moneni PiratesMoneni Pirate |
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| 28 Nov 21 | r04 | TinyosiTinyosi | 0 - 0 | Young BuffaloesYoung Buffalo |
| 05 Dec 21 | r04 | Milling HotspursMilling Hotsp | 0 - 3 | Young BuffaloesYoung Buffalo |
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| 11 Dec 21 | r05 | Young BuffaloesYoung Buffalo | 1 - 0 | Manzini WanderersManzini Wande |
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| 19 Dec 21 | r06 | Young BuffaloesYoung Buffalo | 0 - 0 | Tambankulu CalliesTambankulu Ca |
| 29 Dec 21 | r06 | Denver SundownsDenver Sundow | 1 - 4 | Young BuffaloesYoung Buffalo |
| |
| 02 Jan 22 | r08 | Young BuffaloesYoung Buffalo | 1 - 0 | VovovoVovovo |
| 08 Jan 22 | r08 | TambutiTambuti | 0 - 2 | Young BuffaloesYoung Buffalo |
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| 16 Jan 22 | r09 | Young BuffaloesYoung Buffalo | 5 - 1 | Malanti ChiefsMalanti Chief |
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| 29 Jan 22 | r10 | Young BuffaloesYoung Buffalo | 4 - 0 | Rangers FCRangers FC |
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| 06 Feb 22 | r11 | Green Mamba FCGreen Mamba F | 1 - 4 | Young BuffaloesYoung Buffalo |
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| 10 Feb 22 | r12 | Royal LeopardsRoyal Leopard | 3 - 1 | Young BuffaloesYoung Buffalo |
| 13 Feb 22 | r12 | Young BuffaloesYoung Buffalo | 1 - 1 | Mbabane Swallows F.C.Mbabane Swall |
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| 05 Mar 22 | r13 | Young BuffaloesYoung Buffalo | 4 - 0 | Manzini Sea BirdsManzini Sea B |
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| 13 Mar 22 | r14 | Rangers FCRangers FC | 0 - 4 | Young BuffaloesYoung Buffalo |
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| 30 Mar 22 | r15 | Manzini WanderersManzini Wande | 2 - 5 | Young BuffaloesYoung Buffalo |
| 03 Apr 22 | r15 | VovovoVovovo | 0 - 1 | Young BuffaloesYoung Buffalo |
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| 10 Apr 22 | r16 | Young BuffaloesYoung Buffalo | 4 - 1 | TinyosiTinyosi |
| |
| 16 Apr 22 | r17 | Mbabane HighlandersMbabane Highl | 1 - 3 | Young BuffaloesYoung Buffalo |
| 19 Apr 22 | r17 | Tambankulu CalliesTambankulu Ca | 2 - 2 | Young BuffaloesYoung Buffalo |
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| 23 Apr 22 | r18 | Moneni PiratesMoneni Pirate | 0 - 5 | Young BuffaloesYoung Buffalo |
| |
| 30 Apr 22 | r20 | Young BuffaloesYoung Buffalo | 5 - 1 | TambutiTambuti |
| 04 May 22 | r20 | Young BuffaloesYoung Buffalo | 1 - 1 | Green Mamba FCGreen Mamba F |
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| 08 May 22 | r21 | Young BuffaloesYoung Buffalo | 3 - 0 | Denver SundownsDenver Sundow |
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| 15 May 22 | r22 | Mbabane Swallows F.C.Mbabane Swall | 0 - 0 | Young BuffaloesYoung Buffalo |
| 19 May 22 | r22 | Malanti ChiefsMalanti Chief | 0 - 5 | Young BuffaloesYoung Buffalo |
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| 29 May 22 | r23 | Young BuffaloesYoung Buffalo | 2 - 0 | Milling HotspursMilling Hotsp |
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| 12 Jun 22 | r25 | Young BuffaloesYoung Buffalo | 0 - 0 | Royal LeopardsRoyal Leopard |
Team 2021-2022 Schedules
Amawele
Ezulwini United
Green Mamba
Malanti Chiefs
Manzini Sea Birds
Manzini Wanderers
Mbabane Highlanders
Mbabane Swallows
Moneni Pirates
Nsingizini Hotspurs
Rangers Shiselweni
Royal Leopards
Sisonkhe
Tabankulu Celtics
Ubombo Sugar
Young Buffaloes
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