| 25 Sep 21 | r01        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 0 | Rail Club du KadiogoRail Club du |
| |
| 01 Oct 21 | r02        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 2 | KikoKiko |
| |
| 09 Oct 21 | r03        | MajesticMajestic | 1 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 17 Oct 21 | r04        | US des Forces ArméesUS des Forces | 2 - 1 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 24 Oct 21 | r05        | RC Bobo-DioulassoRC Bobo-Dioul | 1 - 0 | Vitesse Burkina FasoVitesse Burki |
| |
| 31 Oct 21 | r06        | Royal FC Bobo-DioulassoRoyal FC Bobo | 0 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 07 Nov 21 | r07        | RC Bobo-DioulassoRC Bobo-Dioul | 2 - 1 | Salitas FCSalitas FC |
| |
| 14 Nov 21 | r08        | SONABELSONABEL | 1 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 20 Nov 21 | r09        | ASEC KoudougouASEC Koudougo | 0 - 1 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 28 Nov 21 | r10        | AS DouanesAS Douanes | 0 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 10 Dec 21 | r12        | RC Bobo-DioulassoRC Bobo-Dioul | 1 - 1 | AS KoupelaAS Koupela |
| |
| 19 Dec 21 | r13        | Etoile FilanteEtoile Filant | 2 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 29 Dec 21 | r14        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 0 | ASFA-YennengaASFA-Yennenga |
| |
| 03 Jan 22 | r15        | ASF Bobo DioulassoASF Bobo Diou | 0 - 1 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 26 Feb 22 | r16        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 1 | ASF Bobo DioulassoASF Bobo Diou |
| |
| 02 Mar 22 | r17        | ASFA-YennengaASFA-Yennenga | 2 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 06 Mar 22 | r18        | RC Bobo-DioulassoRC Bobo-Dioul | 1 - 0 | Etoile FilanteEtoile Filant |
| |
| 12 Mar 22 | r19        | AS KoupelaAS Koupela | 1 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 24 Mar 22 | r21        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 1 | AS DouanesAS Douanes |
| |
| 27 Mar 22 | r22        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 0 | ASEC KoudougouASEC Koudougo |
| |
| 03 Apr 22 | r23        | RC Bobo-DioulassoRC Bobo-Dioul | 2 - 1 | SONABELSONABEL |
| |
| 10 Apr 22 | r24        | Salitas FCSalitas FC | 1 - 1 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 16 Apr 22 | r25        | RC Bobo-DioulassoRC Bobo-Dioul | 2 - 1 | Royal FC Bobo-DioulassoRoyal FC Bobo |
| |
| 24 Apr 22 | r26        | Vitesse Burkina FasoVitesse Burki | 0 - 1 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 01 May 22 | r27        | RC Bobo-DioulassoRC Bobo-Dioul | 0 - 0 | US des Forces ArméesUS des Forces |
| |
| 08 May 22 | r28        | RC Bobo-DioulassoRC Bobo-Dioul | 2 - 2 | MajesticMajestic |
| |
| 15 May 22 | r29        | KikoKiko | 0 - 0 | RC Bobo-DioulassoRC Bobo-Dioul |
| |
| 22 May 22 | r30        | Rail Club du KadiogoRail Club du | 2 - 1 | RC Bobo-DioulassoRC Bobo-Dioul |