| 31 Oct 21 | r01        | RequinsRequins | 2 - 3 | Coton Sport OuidahCoton Sport O |
| |
| 14 Nov 21 | r02        | SitatungaSitatunga | 1 - 4 | Coton Sport OuidahCoton Sport O |
| |
| 17 Nov 21 | r03        | Coton Sport OuidahCoton Sport O | 1 - 0 | AS CotonouAS Cotonou |
| |
| 28 Nov 21 | r05        | Coton Sport OuidahCoton Sport O | 4 - 1 | AS Police BeninAS Police Ben |
| |
| 01 Dec 21 | r06        | AdjidjaAdjidja | 1 - 3 | Coton Sport OuidahCoton Sport O |
| |
| 04 Dec 21 | r07        | Coton Sport OuidahCoton Sport O | 3 - 1 | ASPACASPAC |
| |
| 12 Dec 21 | r08        | EternelEternel | 1 - 0 | Coton Sport OuidahCoton Sport O |
| |
| 19 Dec 21 | r09        | UPI-ONMUPI-ONM | 0 - 0 | Coton Sport OuidahCoton Sport O |
| |
| 22 Dec 21 | r10        | Coton Sport OuidahCoton Sport O | 1 - 0 | RequinsRequins |
| |
| 29 Dec 21 | r11        | Coton Sport OuidahCoton Sport O | 1 - 0 | SitatungaSitatunga |
| |
| 05 Jan 22 | r12        | AS CotonouAS Cotonou | 2 - 1 | Coton Sport OuidahCoton Sport O |
| |
| 16 Jan 22 | r14        | AS Police BeninAS Police Ben | 0 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 19 Jan 22 | r15        | Coton Sport OuidahCoton Sport O | 3 - 2 | AdjidjaAdjidja |
| |
| 22 Jan 22 | r16        | ASPACASPAC | 1 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 26 Jan 22 | r17        | Coton Sport OuidahCoton Sport O | 1 - 0 | EternelEternel |
| |
| 30 Jan 22 | r18        | Coton Sport OuidahCoton Sport O | 2 - 2 | UPI-ONMUPI-ONM |
| |
| 05 Mar 22 | r01        | PanthèresPanthères | 0 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 09 Mar 22 | r02        | DadjèDadjè | 0 - 1 | Coton Sport OuidahCoton Sport O |
| |
| 12 Mar 22 | r03        | Coton Sport OuidahCoton Sport O | 1 - 1 | JS PobeJS Pobe |
| |
| 20 Mar 22 | r05        | Coton Sport OuidahCoton Sport O | 2 - 1 | Cavaliers FC de NikkiCavaliers FC |
| |
| 23 Mar 22 | r06        | Loto PopoLoto Popo | 1 - 0 | Coton Sport OuidahCoton Sport O |
| |
| 03 Apr 22 | r08        | Les Buffles du BorgouLes Buffles d | 3 - 1 | Coton Sport OuidahCoton Sport O |
| |
| 10 Apr 22 | r09        | Coton Sport OuidahCoton Sport O | 2 - 0 | Dynamo AbomeyDynamo Abomey |
| |
| 13 Apr 22 | r10        | AyemaAyema | 0 - 0 | Coton Sport OuidahCoton Sport O |
| |
| 17 Apr 22 | r11        | Béké BembèrèkèBéké Bembèrèk | 1 - 1 | Coton Sport OuidahCoton Sport O |
| |
| 20 Apr 22 | r01        | Coton Sport OuidahCoton Sport O | 4 - 0 | DjeffaDjeffa |
| |
| 24 Apr 22 | r12        | Coton Sport OuidahCoton Sport O | 2 - 1 | Espoir SavalouEspoir Savalo |
| |
| 08 May 22 | r13        | DjeffaDjeffa | 1 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 11 May 22 | r14        | Coton Sport OuidahCoton Sport O | 1 - 0 | PanthèresPanthères |
| |
| 14 May 22 | r15        | Coton Sport OuidahCoton Sport O | 2 - 1 | DadjèDadjè |
| |
| 18 May 22 | r16        | JS PobeJS Pobe | 1 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 22 May 22 | r17        | Cavaliers FC de NikkiCavaliers FC | 0 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 25 May 22 | r18        | Cavaliers FC de NikkiCavaliers FC | 1 - 0 | Coton Sport OuidahCoton Sport O |
| |
| 29 May 22 | r19        | ASVOASVO | 1 - 0 | Coton Sport OuidahCoton Sport O |
| |
| 01 Jun 22 | r20        | Coton Sport OuidahCoton Sport O | 0 - 0 | Les Buffles du BorgouLes Buffles d |
| |
| 05 Jun 22 | r21        | Dynamo AbomeyDynamo Abomey | 1 - 2 | Coton Sport OuidahCoton Sport O |
| |
| 08 Jun 22 | r22        | Coton Sport OuidahCoton Sport O | 2 - 0 | AyemaAyema |
| |
| 12 Jun 22 | r23        | Coton Sport OuidahCoton Sport O | 2 - 1 | Béké BembèrèkèBéké Bembèrèk |
| |
| 15 Jun 22 | r24        | Espoir SavalouEspoir Savalo | 1 - 0 | Coton Sport OuidahCoton Sport O |