| 06 Nov 21 | r01        | JS PobeJS Pobe | 1 - 2 | AyemaAyema |
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| 14 Nov 21 | r02        | Avrankou OmnisportAvrankou Omni | 0 - 1 | AyemaAyema |
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| 17 Nov 21 | r03        | AyemaAyema | 3 - 0 | DjeffaDjeffa |
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| 20 Nov 21 | r04        | ASVOASVO | 0 - 0 | AyemaAyema |
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| 27 Nov 21 | r05        | AyemaAyema | 2 - 1 | JA CotonouJA Cotonou |
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| 01 Dec 21 | r06        | AyemaAyema | 1 - 0 | Dragons de lOuéméDragons de lO |
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| 04 Dec 21 | r07        | USS KrakéUSS Kraké | 2 - 0 | AyemaAyema |
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| 18 Dec 21 | r09        | AyemaAyema | 4 - 1 | AS Oussou SakaAS Oussou Sak |
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| 22 Dec 21 | r10        | AyemaAyema | 3 - 1 | JS PobeJS Pobe |
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| 29 Dec 21 | r11        | AyemaAyema | 1 - 0 | Avrankou OmnisportAvrankou Omni |
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| 05 Jan 22 | r12        | DjeffaDjeffa | 0 - 0 | AyemaAyema |
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| 09 Jan 22 | r13        | AyemaAyema | 1 - 1 | ASVOASVO |
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| 16 Jan 22 | r14        | JA CotonouJA Cotonou | 1 - 1 | AyemaAyema |
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| 19 Jan 22 | r15        | Dragons de lOuéméDragons de lO | 1 - 1 | AyemaAyema |
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| 23 Jan 22 | r16        | AyemaAyema | 2 - 2 | USS KrakéUSS Kraké |
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| 30 Jan 22 | r18        | AS Oussou SakaAS Oussou Sak | 0 - 3 | AyemaAyema |
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| 05 Mar 22 | r01        | Loto PopoLoto Popo | 2 - 1 | AyemaAyema |
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| 09 Mar 22 | r02        | AyemaAyema | 5 - 2 | Cavaliers FC de NikkiCavaliers FC |
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| 13 Mar 22 | r03        | AdjidjaAdjidja | 0 - 1 | AyemaAyema |
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| 19 Mar 22 | r05        | AyemaAyema | 1 - 0 | DadjèDadjè |
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| 23 Mar 22 | r06        | AyemaAyema | 0 - 0 | Les Buffles du BorgouLes Buffles d |
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| 26 Mar 22 | r07        | AS CotonouAS Cotonou | 1 - 1 | AyemaAyema |
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| 03 Apr 22 | r08        | Espoir SavalouEspoir Savalo | 2 - 2 | AyemaAyema |
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| 09 Apr 22 | r09        | AyemaAyema | 2 - 1 | Béké BembèrèkèBéké Bembèrèk |
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| 13 Apr 22 | r10        | AyemaAyema | 0 - 0 | Coton Sport OuidahCoton Sport O |
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| 16 Apr 22 | r11        | Dynamo AbomeyDynamo Abomey | 1 - 0 | AyemaAyema |
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| 20 Apr 22 | r01        | AyemaAyema | 1 - 0 | EternelEternel |
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| 23 Apr 22 | r12        | PanthèresPanthères | 1 - 1 | AyemaAyema |
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| 08 May 22 | r13        | EternelEternel | 0 - 1 | AyemaAyema |
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| 11 May 22 | r14        | AyemaAyema | 2 - 2 | Loto PopoLoto Popo |
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| 15 May 22 | r15        | Cavaliers FC de NikkiCavaliers FC | 0 - 2 | AyemaAyema |
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| 18 May 22 | r16        | AyemaAyema | 1 - 1 | AdjidjaAdjidja |
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| 21 May 22 | r17        | DadjèDadjè | 2 - 0 | AyemaAyema |
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| 25 May 22 | r18        | DadjèDadjè | 2 - 0 | AyemaAyema |
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| 28 May 22 | r19        | AyemaAyema | 2 - 2 | AS CotonouAS Cotonou |
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| 01 Jun 22 | r20        | AyemaAyema | 0 - 1 | Espoir SavalouEspoir Savalo |
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| 05 Jun 22 | r21        | Béké BembèrèkèBéké Bembèrèk | 0 - 0 | AyemaAyema |
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| 08 Jun 22 | r22        | Coton Sport OuidahCoton Sport O | 2 - 0 | AyemaAyema |
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| 12 Jun 22 | r23        | AyemaAyema | 3 - 2 | Dynamo AbomeyDynamo Abomey |
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| 15 Jun 22 | r24        | AyemaAyema | 1 - 0 | PanthèresPanthères |