| 06 Nov 21 | r01  | AS Police BeninAS Police Ben | 0 - 5 | AS CotonouAS Cotonou |
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| 13 Nov 21 | r02 | AS CotonouAS Cotonou | 0 - 0 | ASPACASPAC |
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| 17 Nov 21 | r03 | Coton Sport OuidahCoton Sport O | 1 - 0 | AS CotonouAS Cotonou |
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| 20 Nov 21 | r04 | AS CotonouAS Cotonou | 0 - 0 | EternelEternel |
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| 27 Nov 21 | r05 | RequinsRequins | 2 - 3 | AS CotonouAS Cotonou |
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| 04 Dec 21 | r07 | AS CotonouAS Cotonou | 1 - 0 | AdjidjaAdjidja |
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| 11 Dec 21 | r08 | AS CotonouAS Cotonou | 4 - 0 | UPI-ONMUPI-ONM |
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| 17 Dec 21 | r09 | SitatungaSitatunga | 0 - 0 | AS CotonouAS Cotonou |
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| 22 Dec 21 | r10 | AS CotonouAS Cotonou | 1 - 0 | AS Police BeninAS Police Ben |
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| 29 Dec 21 | r11 | ASPACASPAC | 0 - 0 | AS CotonouAS Cotonou |
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| 05 Jan 22 | r12 | AS CotonouAS Cotonou | 2 - 1 | Coton Sport OuidahCoton Sport O |
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| 09 Jan 22 | r13 | EternelEternel | 1 - 0 | AS CotonouAS Cotonou |
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| 15 Jan 22 | r14 | AS CotonouAS Cotonou | 0 - 1 | RequinsRequins |
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| 22 Jan 22 | r16 | AdjidjaAdjidja | 2 - 0 | AS CotonouAS Cotonou |
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| 26 Jan 22 | r17 | UPI-ONMUPI-ONM | 1 - 2 | AS CotonouAS Cotonou |
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| 30 Jan 22 | r18 | AS CotonouAS Cotonou | 0 - 1 | SitatungaSitatunga |
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| 06 Mar 22 | r01 | Béké BembèrèkèBéké Bembèrèk | 0 - 3 | AS CotonouAS Cotonou |
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| 09 Mar 22 | r02 | Espoir SavalouEspoir Savalo | 2 - 1 | AS CotonouAS Cotonou |
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| 13 Mar 22 | r04 | AS CotonouAS Cotonou | 1 - 0 | ASVOASVO |
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| 19 Mar 22 | r05 | AS CotonouAS Cotonou | 1 - 2 | PanthèresPanthères |
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| 23 Mar 22 | r06 | DadjèDadjè | 1 - 0 | AS CotonouAS Cotonou |
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| 26 Mar 22 | r07 | AS CotonouAS Cotonou | 1 - 1 | AyemaAyema |
| 27 Mar 22 | r07 | AS CotonouAS Cotonou | 2 - 1 | ASVOASVO |
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| 02 Apr 22 | r08 | Cavaliers FC de NikkiCavaliers FC | 0 - 3 | AS CotonouAS Cotonou |
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| 09 Apr 22 | r09 | AS CotonouAS Cotonou | 1 - 0 | Loto PopoLoto Popo |
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| 13 Apr 22 | r10 | DjeffaDjeffa | 1 - 0 | AS CotonouAS Cotonou |
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| 17 Apr 22 | r11 | Les Buffles du BorgouLes Buffles d | 1 - 0 | AS CotonouAS Cotonou |
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| 20 Apr 22 | r01 | AS CotonouAS Cotonou | 3 - 1 | JS PobeJS Pobe |
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| 23 Apr 22 | r12 | AS CotonouAS Cotonou | 1 - 0 | Dynamo AbomeyDynamo Abomey |
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| 07 May 22 | r13 | JS PobeJS Pobe | 0 - 3 | AS CotonouAS Cotonou |
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| 12 May 22 | r14 | AS CotonouAS Cotonou | 1 - 1 | Béké BembèrèkèBéké Bembèrèk |
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| 15 May 22 | r15 | AS CotonouAS Cotonou | 3 - 0 | Espoir SavalouEspoir Savalo |
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| 18 May 22 | r16 | ASVOASVO | 2 - 0 | AS CotonouAS Cotonou |
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| 22 May 22 | r17 | PanthèresPanthères | 1 - 1 | AS CotonouAS Cotonou |
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| 25 May 22 | r18 | PanthèresPanthères | 2 - 2 | AS CotonouAS Cotonou |
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| 28 May 22 | r19 | AyemaAyema | 2 - 2 | AS CotonouAS Cotonou |
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| 01 Jun 22 | r20 | AS CotonouAS Cotonou | 2 - 0 | Cavaliers FC de NikkiCavaliers FC |
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| 05 Jun 22 | r21 | Loto PopoLoto Popo | 3 - 0 | AS CotonouAS Cotonou |
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| 08 Jun 22 | r22 | AS CotonouAS Cotonou | 0 - 1 | DjeffaDjeffa |
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| 12 Jun 22 | r23 | AS CotonouAS Cotonou | 2 - 2 | Les Buffles du BorgouLes Buffles d |
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| 15 Jun 22 | r24 | Dynamo AbomeyDynamo Abomey | 1 - 0 | AS CotonouAS Cotonou |
Team 2021-2022 Schedules
ASPAC
ASVO
Ayema
Bani Gansè
Cavaliers de Nikki
Coton Sport Ouidah
Cotonou
Dadjè
Damissa
Dragons de l'Ouémé
Dynamo Abomey
Espoir Savalou
Hodio
Kraké
Les Buffles du Borgou
Loto-Popo
Pobè
SOBEMAP
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