| 10 Dec 21 | r08        | AS Police BeninAS Police Ben | 1 - 1 | SitatungaSitatunga |
| 11 Dec 21 | r08        | PanthèresPanthères | 0 - 0 | TukunninTukunnin |
| 11 Dec 21 | r08        | Réal Sports de Parakou FCRéal Sports d | 0 - 0 | Dynamique DjougouDynamique Djo |
| 11 Dec 21 | r08        | AS CotonouAS Cotonou | 4 - 0 | UPI-ONMUPI-ONM |
| 11 Dec 21 | r08        | DjeffaDjeffa | 0 - 0 | USS KrakéUSS Kraké |
| 11 Dec 21 | r08        | JA CotonouJA Cotonou | 1 - 1 | ASVOASVO |
| 11 Dec 21 | r08        | TonnerreTonnerre | 1 - 2 | Espoir SavalouEspoir Savalo |
| 11 Dec 21 | r08        | HodioHodio | 0 - 2 | EnergieEnergie |
| 12 Dec 21 | r08        | Cavaliers FC de NikkiCavaliers FC | 2 - 1 | Dynamo UnacobDynamo Unacob |
| 12 Dec 21 | r08        | Les Buffles du BorgouLes Buffles d | 1 - 0 | Béké BembèrèkèBéké Bembèrèk |
| 12 Dec 21 | r08        | EternelEternel | 1 - 0 | Coton Sport OuidahCoton Sport O |
| 12 Dec 21 | r08        | ASPACASPAC | 1 - 2 | AdjidjaAdjidja |
| 12 Dec 21 | r08        | Dragons de lOuéméDragons de lO | 0 - 1 | JS PobeJS Pobe |
| 12 Dec 21 | r08        | AS Oussou SakaAS Oussou Sak | 3 - 1 | Avrankou OmnisportAvrankou Omni |
| 12 Dec 21 | r08        | SoleilSoleil | 2 - 2 | Loto PopoLoto Popo |
| 12 Dec 21 | r08        | DadjèDadjè | 1 - 0 | Union Sportive du Borgou Union Sportiv |
| 02 Apr 22 | r08        | Loto PopoLoto Popo | 1 - 1 | JS PobeJS Pobe |
| 02 Apr 22 | r08        | Cavaliers FC de NikkiCavaliers FC | 0 - 3 | AS CotonouAS Cotonou |
| 02 Apr 22 | r08        | Dynamo AbomeyDynamo Abomey | 3 - 2 | DjeffaDjeffa |
| 02 Apr 22 | r08        | Béké BembèrèkèBéké Bembèrèk | 1 - 0 | EternelEternel |
| 03 Apr 22 | r08        | Espoir SavalouEspoir Savalo | 2 - 2 | AyemaAyema |
| 03 Apr 22 | r08        | ASVOASVO | 2 - 2 | DadjèDadjè |
| 03 Apr 22 | r08        | AdjidjaAdjidja | 0 - 0 | PanthèresPanthères |
| 03 Apr 22 | r08        | Les Buffles du BorgouLes Buffles d | 3 - 1 | Coton Sport OuidahCoton Sport O |
| 20 Apr 22 | r08        | TonnerreTonnerre | 1 - 0 | SoleilSoleil |
| 20 Apr 22 | r08        | HodioHodio | 1 - 2 | TukunninTukunnin |
| 20 Apr 22 | r08        | DamissaDamissa | 1 - 0 | Réal Sports de Parakou FCRéal Sports d |
| 20 Apr 22 | r08        | Dynamo UnacobDynamo Unacob | 0 - 0 | EnergieEnergie |
| 20 Apr 22 | r08        | ASPACASPAC | 1 - 0 | SitatungaSitatunga |
| 20 Apr 22 | r08        | Dragons de lOuéméDragons de lO | 2 - 1 | AS Oussou SakaAS Oussou Sak |
| 20 Apr 22 | r08        | UPI-ONMUPI-ONM | 1 - 3 | RequinsRequins |
| 20 Apr 22 | r08        | Avrankou OmnisportAvrankou Omni | 1 - 1 | AS Police BeninAS Police Ben |
| 21 Apr 22 | r08        | Union Sportive du Borgou Union Sportiv | 0 - 0 | Dynamique DjougouDynamique Djo |
| 21 Apr 22 | r08        | USS KrakéUSS Kraké | 1 - 0 | JA CotonouJA Cotonou |