| 26 Jan 22 | r17        | UPI-ONMUPI-ONM | 1 - 2 | AS CotonouAS Cotonou |
| 26 Jan 22 | r17        | AdjidjaAdjidja | 1 - 0 | ASPACASPAC |
| 26 Jan 22 | r17        | Coton Sport OuidahCoton Sport O | 1 - 0 | EternelEternel |
| 26 Jan 22 | r17        | Dynamo UnacobDynamo Unacob | 1 - 2 | Cavaliers FC de NikkiCavaliers FC |
| 26 Jan 22 | r17        | Dynamique DjougouDynamique Djo | 0 - 2 | Réal Sports de Parakou FCRéal Sports d |
| 26 Jan 22 | r17        | TukunninTukunnin | 0 - 1 | PanthèresPanthères |
| 26 Jan 22 | r17        | Béké BembèrèkèBéké Bembèrèk | 1 - 0 | Les Buffles du BorgouLes Buffles d |
| 26 Jan 22 | r17        | USS KrakéUSS Kraké | 1 - 2 | DjeffaDjeffa |
| 26 Jan 22 | r17        | JS PobeJS Pobe | 1 - 0 | Dragons de lOuéméDragons de lO |
| 26 Jan 22 | r17        | ASVOASVO | 2 - 0 | JA CotonouJA Cotonou |
| 26 Jan 22 | r17        | EnergieEnergie | 0 - 1 | HodioHodio |
| 26 Jan 22 | r17        | Loto PopoLoto Popo | 1 - 0 | SoleilSoleil |
| 26 Jan 22 | r17        | Espoir SavalouEspoir Savalo | 0 - 0 | TonnerreTonnerre |
| 27 Jan 22 | r17        | SitatungaSitatunga | 2 - 1 | AS Police BeninAS Police Ben |
| 27 Jan 22 | r17        | Avrankou OmnisportAvrankou Omni | 0 - 1 | AS Oussou SakaAS Oussou Sak |
| 27 Jan 22 | r17        | Union Sportive du Borgou Union Sportiv | 0 - 2 | DadjèDadjè |
| 21 May 22 | r17        | EternelEternel | 0 - 0 | Les Buffles du BorgouLes Buffles d |
| 21 May 22 | r17        | DjeffaDjeffa | 0 - 1 | Espoir SavalouEspoir Savalo |
| 21 May 22 | r17        | DadjèDadjè | 2 - 0 | AyemaAyema |
| 21 May 22 | r17        | ASVOASVO | 0 - 0 | Loto PopoLoto Popo |
| 22 May 22 | r17        | AdjidjaAdjidja | 1 - 1 | Béké BembèrèkèBéké Bembèrèk |
| 22 May 22 | r17        | JS PobeJS Pobe | 5 - 0 | Dynamo AbomeyDynamo Abomey |
| 22 May 22 | r17        | Cavaliers FC de NikkiCavaliers FC | 0 - 2 | Coton Sport OuidahCoton Sport O |
| 22 May 22 | r17        | PanthèresPanthères | 1 - 1 | AS CotonouAS Cotonou |
| 08 Jun 22 | r17        | SitatungaSitatunga | 1 - 2 | ASPACASPAC |
| 08 Jun 22 | r17        | EnergieEnergie | 2 - 0 | Dynamo UnacobDynamo Unacob |
| 08 Jun 22 | r17        | SoleilSoleil | 1 - 0 | TonnerreTonnerre |
| 08 Jun 22 | r17        | TukunninTukunnin | 2 - 4 | HodioHodio |
| 08 Jun 22 | r17        | Dynamique DjougouDynamique Djo | 1 - 1 | Union Sportive du Borgou Union Sportiv |
| 08 Jun 22 | r17        | AS Oussou SakaAS Oussou Sak | 1 - 1 | Dragons de lOuéméDragons de lO |
| 08 Jun 22 | r17        | AS Police BeninAS Police Ben | 2 - 0 | Avrankou OmnisportAvrankou Omni |
| 08 Jun 22 | r17        | JA CotonouJA Cotonou | 0 - 0 | USS KrakéUSS Kraké |
| 08 Jun 22 | r17        | RequinsRequins | 1 - 1 | UPI-ONMUPI-ONM |
| 09 Jun 22 | r17        | Réal Sports de Parakou FCRéal Sports d | 1 - 0 | DamissaDamissa |