| 15 Jan 22 | r14        | AS CotonouAS Cotonou | 0 - 1 | RequinsRequins |
| 15 Jan 22 | r14        | UPI-ONMUPI-ONM | 1 - 3 | EternelEternel |
| 15 Jan 22 | r14        | Cavaliers FC de NikkiCavaliers FC | 0 - 1 | DamissaDamissa |
| 15 Jan 22 | r14        | PanthèresPanthères | 3 - 1 | Dynamique DjougouDynamique Djo |
| 15 Jan 22 | r14        | DjeffaDjeffa | 1 - 0 | JS PobeJS Pobe |
| 15 Jan 22 | r14        | Avrankou OmnisportAvrankou Omni | 1 - 4 | USS KrakéUSS Kraké |
| 15 Jan 22 | r14        | EnergieEnergie | 2 - 0 | SoleilSoleil |
| 15 Jan 22 | r14        | Union Sportive du Borgou Union Sportiv | 0 - 1 | Espoir SavalouEspoir Savalo |
| 16 Jan 22 | r14        | AdjidjaAdjidja | 1 - 1 | SitatungaSitatunga |
| 16 Jan 22 | r14        | AS Police BeninAS Police Ben | 0 - 2 | Coton Sport OuidahCoton Sport O |
| 16 Jan 22 | r14        | Dynamo UnacobDynamo Unacob | 0 - 1 | Réal Sports de Parakou FCRéal Sports d |
| 16 Jan 22 | r14        | Béké BembèrèkèBéké Bembèrèk | 1 - 1 | TukunninTukunnin |
| 16 Jan 22 | r14        | JA CotonouJA Cotonou | 1 - 1 | AyemaAyema |
| 16 Jan 22 | r14        | ASVOASVO | 2 - 0 | Dragons de lOuéméDragons de lO |
| 16 Jan 22 | r14        | TonnerreTonnerre | 1 - 1 | Loto PopoLoto Popo |
| 16 Jan 22 | r14        | HodioHodio | 0 - 2 | Dynamo AbomeyDynamo Abomey |
| 11 May 22 | r14        | AyemaAyema | 2 - 2 | Loto PopoLoto Popo |
| 11 May 22 | r14        | DjeffaDjeffa | 1 - 0 | DadjèDadjè |
| 11 May 22 | r14        | Coton Sport OuidahCoton Sport O | 1 - 0 | PanthèresPanthères |
| 11 May 22 | r14        | AdjidjaAdjidja | 0 - 1 | Les Buffles du BorgouLes Buffles d |
| 11 May 22 | r14        | Cavaliers FC de NikkiCavaliers FC | 1 - 2 | EternelEternel |
| 11 May 22 | r14        | ASVOASVO | 1 - 0 | Dynamo AbomeyDynamo Abomey |
| 11 May 22 | r14        | Espoir SavalouEspoir Savalo | 3 - 0 | JS PobeJS Pobe |
| 12 May 22 | r14        | AS CotonouAS Cotonou | 1 - 1 | Béké BembèrèkèBéké Bembèrèk |
| 21 May 22 | r14        | Dynamique DjougouDynamique Djo | 1 - 0 | Réal Sports de Parakou FCRéal Sports d |
| 21 May 22 | r14        | Union Sportive du Borgou Union Sportiv | 0 - 0 | TukunninTukunnin |
| 21 May 22 | r14        | EnergieEnergie | 1 - 1 | SoleilSoleil |
| 21 May 22 | r14        | DamissaDamissa | 1 - 1 | HodioHodio |
| 21 May 22 | r14        | Dynamo UnacobDynamo Unacob | 2 - 0 | TonnerreTonnerre |
| 21 May 22 | r14        | AS Police BeninAS Police Ben | 0 - 2 | RequinsRequins |
| 21 May 22 | r14        | USS KrakéUSS Kraké | 1 - 2 | SitatungaSitatunga |
| 21 May 22 | r14        | JA CotonouJA Cotonou | 2 - 1 | AS Oussou SakaAS Oussou Sak |
| 22 May 22 | r14        | Avrankou OmnisportAvrankou Omni | 1 - 0 | UPI-ONMUPI-ONM |
| 22 May 22 | r14        | Dragons de lOuéméDragons de lO | 0 - 1 | ASPACASPAC |