| 22 Dec 21 | r10        | DamissaDamissa | 1 - 0 | Dynamique DjougouDynamique Djo |
| 22 Dec 21 | r10        | Dynamo UnacobDynamo Unacob | 1 - 1 | Les Buffles du BorgouLes Buffles d |
| 22 Dec 21 | r10        | TukunninTukunnin | 1 - 1 | Réal Sports de Parakou FCRéal Sports d |
| 22 Dec 21 | r10        | Coton Sport OuidahCoton Sport O | 1 - 0 | RequinsRequins |
| 22 Dec 21 | r10        | AS CotonouAS Cotonou | 1 - 0 | AS Police BeninAS Police Ben |
| 22 Dec 21 | r10        | UPI-ONMUPI-ONM | 2 - 1 | ASPACASPAC |
| 22 Dec 21 | r10        | AyemaAyema | 3 - 1 | JS PobeJS Pobe |
| 22 Dec 21 | r10        | JA CotonouJA Cotonou | 1 - 1 | DjeffaDjeffa |
| 22 Dec 21 | r10        | ASVOASVO | 0 - 0 | AS Oussou SakaAS Oussou Sak |
| 22 Dec 21 | r10        | USS KrakéUSS Kraké | 0 - 1 | Dragons de lOuéméDragons de lO |
| 22 Dec 21 | r10        | Dynamo AbomeyDynamo Abomey | 2 - 0 | Loto PopoLoto Popo |
| 22 Dec 21 | r10        | HodioHodio | 3 - 0 | TonnerreTonnerre |
| 22 Dec 21 | r10        | EnergieEnergie | 1 - 2 | DadjèDadjè |
| 22 Dec 21 | r10        | Espoir SavalouEspoir Savalo | 2 - 0 | SoleilSoleil |
| 23 Dec 21 | r10        | Cavaliers FC de NikkiCavaliers FC | 1 - 2 | PanthèresPanthères |
| 23 Dec 21 | r10        | SitatungaSitatunga | 0 - 0 | EternelEternel |
| 13 Apr 22 | r10        | AyemaAyema | 0 - 0 | Coton Sport OuidahCoton Sport O |
| 13 Apr 22 | r10        | ASVOASVO | 0 - 0 | EternelEternel |
| 13 Apr 22 | r10        | AdjidjaAdjidja | 0 - 1 | JS PobeJS Pobe |
| 13 Apr 22 | r10        | DjeffaDjeffa | 1 - 0 | AS CotonouAS Cotonou |
| 13 Apr 22 | r10        | Cavaliers FC de NikkiCavaliers FC | 1 - 1 | DadjèDadjè |
| 13 Apr 22 | r10        | Loto PopoLoto Popo | 0 - 0 | Les Buffles du BorgouLes Buffles d |
| 13 Apr 22 | r10        | Dynamo AbomeyDynamo Abomey | 1 - 0 | Béké BembèrèkèBéké Bembèrèk |
| 13 Apr 22 | r10        | Espoir SavalouEspoir Savalo | 0 - 1 | PanthèresPanthères |
| 30 Apr 22 | r10        | SoleilSoleil | 0 - 0 | TukunninTukunnin |
| 30 Apr 22 | r10        | EnergieEnergie | 0 - 1 | DamissaDamissa |
| 30 Apr 22 | r10        | Union Sportive du Borgou Union Sportiv | 0 - 2 | Dynamo UnacobDynamo Unacob |
| 30 Apr 22 | r10        | RequinsRequins | 4 - 1 | SitatungaSitatunga |
| 30 Apr 22 | r10        | AS Police BeninAS Police Ben | 1 - 2 | Dragons de lOuéméDragons de lO |
| 30 Apr 22 | r10        | USS KrakéUSS Kraké | 1 - 2 | Avrankou OmnisportAvrankou Omni |
| 01 May 22 | r10        | Dynamique DjougouDynamique Djo | 1 - 1 | TonnerreTonnerre |
| 01 May 22 | r10        | Réal Sports de Parakou FCRéal Sports d | 0 - 1 | HodioHodio |
| 01 May 22 | r10        | JA CotonouJA Cotonou | 1 - 0 | UPI-ONMUPI-ONM |
| 01 May 22 | r10        | AS Oussou SakaAS Oussou Sak | 0 - 1 | ASPACASPAC |