| 20 Nov 21 | r04        | PanthèresPanthères | 1 - 2 | Béké BembèrèkèBéké Bembèrèk |
| 20 Nov 21 | r04        | Dynamo UnacobDynamo Unacob | 3 - 1 | DamissaDamissa |
| 20 Nov 21 | r04        | AS CotonouAS Cotonou | 0 - 0 | EternelEternel |
| 20 Nov 21 | r04        | ASPACASPAC | 0 - 0 | SitatungaSitatunga |
| 20 Nov 21 | r04        | DjeffaDjeffa | 3 - 0 | Avrankou OmnisportAvrankou Omni |
| 20 Nov 21 | r04        | ASVOASVO | 0 - 0 | AyemaAyema |
| 20 Nov 21 | r04        | HodioHodio | 0 - 2 | SoleilSoleil |
| 20 Nov 21 | r04        | DadjèDadjè | 1 - 1 | Espoir SavalouEspoir Savalo |
| 21 Nov 21 | r04        | Cavaliers FC de NikkiCavaliers FC | 2 - 0 | Réal Sports de Parakou FCRéal Sports d |
| 21 Nov 21 | r04        | Les Buffles du BorgouLes Buffles d | 3 - 0 | TukunninTukunnin |
| 21 Nov 21 | r04        | AS Police BeninAS Police Ben | 1 - 0 | AdjidjaAdjidja |
| 21 Nov 21 | r04        | UPI-ONMUPI-ONM | 0 - 0 | RequinsRequins |
| 21 Nov 21 | r04        | JA CotonouJA Cotonou | 2 - 0 | Dragons de lOuéméDragons de lO |
| 21 Nov 21 | r04        | AS Oussou SakaAS Oussou Sak | 1 - 0 | USS KrakéUSS Kraké |
| 21 Nov 21 | r04        | TonnerreTonnerre | 1 - 0 | Union Sportive du Borgou Union Sportiv |
| 21 Nov 21 | r04        | EnergieEnergie | 1 - 1 | Dynamo AbomeyDynamo Abomey |
| 12 Mar 22 | r04        | Les Buffles du BorgouLes Buffles d | 1 - 2 | Espoir SavalouEspoir Savalo |
| 12 Mar 22 | r04        | DjeffaDjeffa | 1 - 0 | EternelEternel |
| 13 Mar 22 | r04        | Cavaliers FC de NikkiCavaliers FC | 2 - 1 | Dynamo AbomeyDynamo Abomey |
| 13 Mar 22 | r04        | Béké BembèrèkèBéké Bembèrèk | 1 - 1 | DadjèDadjè |
| 13 Mar 22 | r04        | AS CotonouAS Cotonou | 1 - 0 | ASVOASVO |
| 30 Mar 22 | r04        | DamissaDamissa | 0 - 0 | TonnerreTonnerre |
| 30 Mar 22 | r04        | EnergieEnergie | 0 - 1 | TukunninTukunnin |
| 30 Mar 22 | r04        | Dynamo UnacobDynamo Unacob | 0 - 1 | Réal Sports de Parakou FCRéal Sports d |
| 30 Mar 22 | r04        | Dynamique DjougouDynamique Djo | 1 - 0 | SoleilSoleil |
| 30 Mar 22 | r04        | JA CotonouJA Cotonou | 0 - 1 | RequinsRequins |
| 30 Mar 22 | r04        | AS Police BeninAS Police Ben | 0 - 4 | SitatungaSitatunga |
| 30 Mar 22 | r04        | Avrankou OmnisportAvrankou Omni | 0 - 0 | AS Oussou SakaAS Oussou Sak |
| 30 Mar 22 | r04        | Dragons de lOuéméDragons de lO | 3 - 1 | UPI-ONMUPI-ONM |
| 31 Mar 22 | r04        | Union Sportive du Borgou Union Sportiv | 1 - 1 | HodioHodio |
| 31 Mar 22 | r04        | USS KrakéUSS Kraké | 0 - 2 | ASPACASPAC |