| 13 Dec 25 | r22        | Exmouth TownExmouth Town | 3 - 2 | Swindon SupermarineSwindon Super |
| 13 Dec 25 | r22        | Hartpury UniversityHartpury Univ | 0 - 0 | Winchester CityWinchester Ci |
| 13 Dec 25 | r22        | TavistockTavistock | 0 - 4 | Frome TownFrome Town |
| 13 Dec 25 | r22        | MouseholeMousehole | 1 - 2 | Malvern TownMalvern Town |
| 13 Dec 25 | r22        | Larkhall AthleticLarkhall Athl | 4 - 4 | Bishop's CleeveBishop's Clee |
| 13 Dec 25 | r22        | Westbury UnitedWestbury Unit | 0 - 2 | BidefordBideford |
| 13 Dec 25 | r22        | BashleyBashley | 1 - 3 | Falmouth TownFalmouth Town |
| 13 Dec 25 | r22        | ShaftesburyShaftesbury | 2 - 0 | BrixhamBrixham |
| 13 Dec 25 | r22        | Didcot TownDidcot Town | 0 - 4 | Portishead TownPortishead To |
| 13 Dec 25 | r22        | Sporting Club InkberrowSporting Club | 1 - 1 | Melksham TownMelksham Town |
| 13 Dec 25 | r22        | Willand RoversWilland Rover | 1 - 1 | Bristol Manor FarmBristol Manor |