| 23 Oct 21 | r10        | Ashford UnitedAshford Unite | 2 - 0 | Whitstable TownWhitstable To |
| 23 Oct 21 | r10        | Burgess Hill TownBurgess Hill | 3 - 2 | Sevenoaks TownSevenoaks Tow |
| 23 Oct 21 | r10        | Chichester CityChichester Ci | 1 - 1 | Hythe TownHythe Town |
| 23 Oct 21 | r10        | CorinthianCorinthian | 2 - 1 | RamsgateRamsgate |
| 23 Oct 21 | r10        | East Grinstead TownEast Grinstea | 1 - 1 | LancingLancing |
| 23 Oct 21 | r10        | Faversham TownFaversham Tow | 1 - 0 | WhitehawkWhitehawk |
| 23 Oct 21 | r10        | Herne BayHerne Bay | 3 - 0 | VCD AthleticVCD Athletic |
| 23 Oct 21 | r10        | Phoenix SportsPhoenix Sport | 2 - 4 | Hastings UnitedHastings Unit |
| 23 Oct 21 | r10        | SittingbourneSittingbourne | 0 - 6 | Cray Valley PMCray Valley P |
| 23 Oct 21 | r10        | Three BridgesThree Bridges | 1 - 6 | Haywards Heath TownHaywards Heat |