| 21 Aug 21 | r01  | Excelsior 31Excelsior 31 | 3 - 1 | Ter LeedeTer Leede |
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| 28 Aug 21 | r02 | BVV BarendrechtBVV Barendrec | 1 - 3 | Excelsior 31Excelsior 31 |
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| 04 Sep 21 | r03 | Excelsior 31Excelsior 31 | 1 - 2 | VVSBVVSB |
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| 11 Sep 21 | r04 | SteDoCoSteDoCo | 0 - 0 | Excelsior 31Excelsior 31 |
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| 18 Sep 21 | r05 | VV StaphorstVV Staphorst | 2 - 2 | Excelsior 31Excelsior 31 |
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| 25 Sep 21 | r06 | Excelsior 31Excelsior 31 | 4 - 1 | Sportlust 46Sportlust 46 |
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| 02 Oct 21 | r07 | VVOGVVOG | 2 - 1 | Excelsior 31Excelsior 31 |
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| 09 Oct 21 | r08 | Excelsior 31Excelsior 31 | 2 - 0 | AFC Ajax AmateursAFC Ajax Amat |
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| 16 Oct 21 | r09 | VV GoesVV Goes | 1 - 3 | Excelsior 31Excelsior 31 |
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| 30 Oct 21 | r10 | Excelsior 31Excelsior 31 | 1 - 3 | FC LisseFC Lisse |
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| 13 Nov 21 | r12 | Excelsior 31Excelsior 31 | 3 - 2 | Harkemase BoysHarkemase Boy |
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| 20 Nov 21 | r13 | Sparta NijkerkSparta Nijker | 2 - 1 | Excelsior 31Excelsior 31 |
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| 27 Nov 21 | r14 | Excelsior 31Excelsior 31 | 3 - 0 | ACVACV |
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| 12 Feb 22 | r11 | VV DOVOVV DOVO | 0 - 2 | Excelsior 31Excelsior 31 |
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| 19 Feb 22 | r15 | HSV ODIN 59HSV ODIN 59 | 5 - 1 | Excelsior 31Excelsior 31 |
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| 26 Feb 22 | r16 | Excelsior 31Excelsior 31 | 0 - 0 | HSV HoekHSV Hoek |
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| 05 Mar 22 | r17 | DVS 33 ErmeloDVS 33 Ermelo | 2 - 1 | Excelsior 31Excelsior 31 |
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| 12 Mar 22 | r18 | Excelsior 31Excelsior 31 | 2 - 0 | VV StaphorstVV Staphorst |
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| 26 Mar 22 | r20 | Excelsior 31Excelsior 31 | 1 - 0 | VV DOVOVV DOVO |
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| 29 Mar 22 | r19 | Sportlust 46Sportlust 46 | 2 - 2 | Excelsior 31Excelsior 31 |
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| 02 Apr 22 | r23 | Excelsior 31Excelsior 31 | 2 - 1 | VVOGVVOG |
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| 05 Apr 22 | r22 | Excelsior 31Excelsior 31 | 0 - 0 | BVV BarendrechtBVV Barendrec |
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| 09 Apr 22 | r24 | FC LisseFC Lisse | 0 - 0 | Excelsior 31Excelsior 31 |
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| 12 Apr 22 | r21 | VVSBVVSB | 4 - 2 | Excelsior 31Excelsior 31 |
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| 16 Apr 22 | r25 | Excelsior 31Excelsior 31 | 3 - 3 | VV GoesVV Goes |
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| 18 Apr 22 | r26 | AFC Ajax AmateursAFC Ajax Amat | 0 - 1 | Excelsior 31Excelsior 31 |
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| 23 Apr 22 | r27 | Excelsior 31Excelsior 31 | 3 - 1 | DVS 33 ErmeloDVS 33 Ermelo |
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| 30 Apr 22 | r28 | Ter LeedeTer Leede | 2 - 1 | Excelsior 31Excelsior 31 |
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| 07 May 22 | r29 | Harkemase BoysHarkemase Boy | 2 - 0 | Excelsior 31Excelsior 31 |
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| 14 May 22 | r30 | Excelsior 31Excelsior 31 | 0 - 4 | Sparta NijkerkSparta Nijker |
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| 21 May 22 | r31 | HSV HoekHSV Hoek | 2 - 1 | Excelsior 31Excelsior 31 |
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| 25 May 22 | r32 | Excelsior 31Excelsior 31 | 0 - 0 | SteDoCoSteDoCo |
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| 28 May 22 | r33 | ACVACV | 0 - 2 | Excelsior 31Excelsior 31 |
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| 04 Jun 22 | r34 | Excelsior 31Excelsior 31 | 2 - 2 | HSV ODIN 59HSV ODIN 59 |
Team 2021-2022 Schedules
ACV
ADO '20
DOVO
DVS '33 Ermelo
Eemdijk
Excelsior '31
Genemuiden
Harkemase Boys
Hoogeveen
HSC '21
Huizen
Scherpenzeel
Sparta Nijkerk
Sportlust '46
Staphorst
TEC
Urk
USV Hercules
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