| 24 Jul 21 | r11        | FC SKA Rostov-on-DonFC SKA Rostov | 0 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 01 Aug 21 | r12        | PFC Spartak NalchikPFC Spartak N | 0 - 1 | PFC Dynamo StavropolPFC Dynamo St |
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| 07 Aug 21 | r13        | FC Chernomorets NovorossiFC Chernomore | 1 - 1 | PFC Spartak NalchikPFC Spartak N |
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| 15 Aug 21 | r14        | PFC Spartak NalchikPFC Spartak N | 2 - 1 | FC YessentukiFC Yessentuki |
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| 18 Aug 21 | r15        | FC Biolog-NovokubanskFC Biolog-Nov | 1 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 29 Aug 21 | r16        | PFC Spartak NalchikPFC Spartak N | 1 - 1 | FC Legion Dynamo MakhachkFC Legion Dyn |
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| 04 Sep 21 | r17        | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 1 - 2 | PFC Spartak NalchikPFC Spartak N |
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| 12 Sep 21 | r19        | PFC Spartak NalchikPFC Spartak N | 1 - 0 | Chayka PeschanokopskoyeChayka Pescha |
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| 18 Sep 21 | r110        | Anzhi MakhachkalaAnzhi Makhach | 2 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 26 Sep 21 | r111        | PFC Spartak NalchikPFC Spartak N | 0 - 0 | FC Druzhba MaykopFC Druzhba Ma |
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| 03 Oct 21 | r112        | Alaniya Vladikavkaz IIAlaniya Vladi | 1 - 5 | PFC Spartak NalchikPFC Spartak N |
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| 10 Oct 21 | r113        | PFC Spartak NalchikPFC Spartak N | 1 - 1 | FC Kuban-Holding PavlovskFC Kuban-Hold |
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| 17 Oct 21 | r114        | FC Forte TaganrogFC Forte Taga | 0 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 24 Oct 21 | r115        | PFC Spartak NalchikPFC Spartak N | 0 - 1 | FC Anzhi MakhachkalaFC Anzhi Makh |
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| 31 Oct 21 | r116        | Rotor-2Rotor-2 | 0 - 3 | PFC Spartak NalchikPFC Spartak N |
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| 05 Nov 21 | r117        | PFC Spartak NalchikPFC Spartak N | 1 - 1 | FC TuapseFC Tuapse |
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| 13 Nov 21 | r118        | PFC Dynamo StavropolPFC Dynamo St | 0 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 19 Nov 21 | r119        | PFC Spartak NalchikPFC Spartak N | 1 - 0 | FC Chernomorets NovorossiFC Chernomore |
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| 07 Mar 22 | r120        | FC YessentukiFC Yessentuki | 0 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 20 Mar 22 | r122        | FC Legion Dynamo MakhachkFC Legion Dyn | 2 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 27 Mar 22 | r123        | PFC Spartak NalchikPFC Spartak N | 1 - 3 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV |
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| 06 Apr 22 | r121        | PFC Spartak NalchikPFC Spartak N | 0 - 1 | FC Biolog-NovokubanskFC Biolog-Nov |
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| 10 Apr 22 | QF        | Chayka PeschanokopskoyeChayka Pescha | 3 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 17 Apr 22 | r126        | PFC Spartak NalchikPFC Spartak N | 3 - 1 | Anzhi MakhachkalaAnzhi Makhach |
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| 23 Apr 22 | r127        | FC Druzhba MaykopFC Druzhba Ma | 1 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 30 Apr 22 | r128        | PFC Spartak NalchikPFC Spartak N | 0 - 0 | Alaniya Vladikavkaz IIAlaniya Vladi |
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| 06 May 22 | r129        | FC Kuban-Holding PavlovskFC Kuban-Hold | 0 - 3 | PFC Spartak NalchikPFC Spartak N |
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| 12 May 22 | r130        | PFC Spartak NalchikPFC Spartak N | 0 - 2 | FC Forte TaganrogFC Forte Taga |
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| 16 May 22 | r131        | FC Anzhi MakhachkalaFC Anzhi Makh | 1 - 0 | PFC Spartak NalchikPFC Spartak N |
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| 22 May 22 | r132        | PFC Spartak NalchikPFC Spartak N | 2 - 0 | Rotor-2Rotor-2 |
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| 30 May 22 | r133        | FC TuapseFC Tuapse | 0 - 4 | PFC Spartak NalchikPFC Spartak N |
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| 05 Jun 22 | r134        | PFC Spartak NalchikPFC Spartak N | 1 - 2 | FC SKA Rostov-on-DonFC SKA Rostov |