| 12 Sep 21 | r19        | PFC Dynamo StavropolPFC Dynamo St | 2 - 3 | FC Anzhi MakhachkalaFC Anzhi Makh |
| 12 Sep 21 | r19        | PFC Spartak NalchikPFC Spartak N | 1 - 0 | Chayka PeschanokopskoyeChayka Pescha |
| 12 Sep 21 | r19        | FC Biolog-NovokubanskFC Biolog-Nov | 5 - 3 | Alaniya Vladikavkaz IIAlaniya Vladi |
| 12 Sep 21 | r19        | FC SKA Rostov-on-DonFC SKA Rostov | 1 - 0 | Rotor-2Rotor-2 |
| 12 Sep 21 | r19        | FC Chernomorets NovorossiFC Chernomore | 2 - 2 | FC Forte TaganrogFC Forte Taga |
| 13 Sep 21 | r19        | FC Legion Dynamo MakhachkFC Legion Dyn | 1 - 2 | FC Druzhba MaykopFC Druzhba Ma |
| 13 Sep 21 | r19        | FC YessentukiFC Yessentuki | 1 - 2 | FC Kuban-Holding PavlovskFC Kuban-Hold |
| 13 Sep 21 | r19        | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 0 - 3 | Anzhi MakhachkalaAnzhi Makhach |