| 15 Aug 21 | r14        | Anzhi MakhachkalaAnzhi Makhach | 2 - 1 | PFC Dynamo StavropolPFC Dynamo St |
| 15 Aug 21 | r14        | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 2 - 0 | FC Biolog-NovokubanskFC Biolog-Nov |
| 15 Aug 21 | r14        | Chayka PeschanokopskoyeChayka Pescha | 1 - 0 | FC Chernomorets NovorossiFC Chernomore |
| 15 Aug 21 | r14        | FC TuapseFC Tuapse | 3 - 1 | Alaniya Vladikavkaz IIAlaniya Vladi |
| 15 Aug 21 | r14        | PFC Spartak NalchikPFC Spartak N | 2 - 1 | FC YessentukiFC Yessentuki |
| 15 Aug 21 | r14        | FC Druzhba MaykopFC Druzhba Ma | 1 - 4 | FC SKA Rostov-on-DonFC SKA Rostov |
| 15 Aug 21 | r14        | FC Forte TaganrogFC Forte Taga | 0 - 0 | FC Anzhi MakhachkalaFC Anzhi Makh |
| 22 Sep 21 | r14        | FC Kuban-Holding PavlovskFC Kuban-Hold | 4 - 0 | Rotor-2Rotor-2 |