| 27 Oct 21 |
r119        | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 7 - 0 | FC YessentukiFC Yessentuki |
| 19 Nov 21 |
r119        | Anzhi MakhachkalaAnzhi Makhach | 0 - 0 | FC SKA Rostov-on-DonFC SKA Rostov |
| 19 Nov 21 |
r119        | PFC Spartak NalchikPFC Spartak N | 1 - 0 | FC Chernomorets NovorossiFC Chernomore |
| 19 Nov 21 |
r119        | FC Druzhba MaykopFC Druzhba Ma | 1 - 0 | FC TuapseFC Tuapse |
| 20 Nov 21 |
r119        | FC Legion Dynamo MakhachkFC Legion Dyn | 1 - 0 | FC Biolog-NovokubanskFC Biolog-Nov |
| 20 Nov 21 |
r119        | FC Kuban-Holding PavlovskFC Kuban-Hold | 1 - 0 | FC Anzhi MakhachkalaFC Anzhi Makh |
| 20 Nov 21 |
r119        | Chayka PeschanokopskoyeChayka Pescha | 7 - 0 | PFC Dynamo StavropolPFC Dynamo St |
| 20 Nov 21 |
r119        | Alaniya Vladikavkaz IIAlaniya Vladi | 2 - 2 | Rotor-2Rotor-2 |