| 03 Oct 21 | r112        | FC Anzhi MakhachkalaFC Anzhi Makh | 2 - 0 | FC Biolog-NovokubanskFC Biolog-Nov |
| 03 Oct 21 | r112        | FC Kuban-Holding PavlovskFC Kuban-Hold | 1 - 0 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV |
| 03 Oct 21 | r112        | FC SKA Rostov-on-DonFC SKA Rostov | 2 - 1 | PFC Dynamo StavropolPFC Dynamo St |
| 03 Oct 21 | r112        | FC Forte TaganrogFC Forte Taga | 2 - 1 | FC Legion Dynamo MakhachkFC Legion Dyn |
| 03 Oct 21 | r112        | Alaniya Vladikavkaz IIAlaniya Vladi | 1 - 5 | PFC Spartak NalchikPFC Spartak N |
| 03 Oct 21 | r112        | FC Druzhba MaykopFC Druzhba Ma | 0 - 2 | Chayka PeschanokopskoyeChayka Pescha |
| 04 Oct 21 | r112        | FC TuapseFC Tuapse | 0 - 1 | FC Chernomorets NovorossiFC Chernomore |
| 05 Oct 21 | r112        | Rotor-2Rotor-2 | 6 - 0 | FC YessentukiFC Yessentuki |