| 17 Sep 21 | r110        | Rotor-2Rotor-2 | 2 - 1 | PFC Dynamo StavropolPFC Dynamo St |
| 18 Sep 21 | r110        | Alaniya Vladikavkaz IIAlaniya Vladi | 0 - 2 | FC Legion Dynamo MakhachkFC Legion Dyn |
| 18 Sep 21 | r110        | Anzhi MakhachkalaAnzhi Makhach | 2 - 0 | PFC Spartak NalchikPFC Spartak N |
| 18 Sep 21 | r110        | FC Anzhi MakhachkalaFC Anzhi Makh | 3 - 0 | FC Chernomorets NovorossiFC Chernomore |
| 18 Sep 21 | r110        | FC Forte TaganrogFC Forte Taga | 6 - 0 | FC YessentukiFC Yessentuki |
| 18 Sep 21 | r110        | FC Kuban-Holding PavlovskFC Kuban-Hold | 2 - 1 | FC Biolog-NovokubanskFC Biolog-Nov |
| 18 Sep 21 | r110        | FC Druzhba MaykopFC Druzhba Ma | 1 - 1 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV |
| 20 Sep 21 | r110        | FC TuapseFC Tuapse | 0 - 2 | FC SKA Rostov-on-DonFC SKA Rostov |