| 09 Oct 21 | r06        | Sheffield United WFCSheffield Uni | 0 - 2 | Liverpool FC WomenLiverpool FC |
| 10 Oct 21 | r06        | Lewes FC WomenLewes FC Wome | 1 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 10 Oct 21 | r06        | Sunderland WomenSunderland Wo | 0 - 2 | Durham WFCDurham WFC |
| 10 Oct 21 | r06        | Charlton Athletic WFCCharlton Athl | 2 - 1 | Bristol City WFCBristol City |
| 10 Oct 21 | r06        | Coventry United LFCCoventry Unit | 2 - 3 | Crystal Palace FC WomenCrystal Palac |
| 10 Oct 21 | r06        | London City LionessesLondon City L | 2 - 1 | Watford WomenWatford Women |
| 16 Oct 22 | r06        | Charlton Athletic WFCCharlton Athl | 2 - 2 | Blackburn Rovers LFCBlackburn Rov |
| 16 Oct 22 | r06        | Crystal Palace FC WomenCrystal Palac | 0 - 2 | Sunderland WomenSunderland Wo |
| 16 Oct 22 | r06        | Durham WFCDurham WFC | 2 - 1 | Lewes FC WomenLewes FC Wome |
| 16 Oct 22 | r06        | Coventry United LFCCoventry Unit | 0 - 5 | London City LionessesLondon City L |
| 16 Oct 22 | r06        | Sheffield United WFCSheffield Uni | 1 - 3 | Bristol City WFCBristol City |
| 17 Oct 22 | r06        | Southampton F.C. WomenSouthampton F | 1 - 0 | Birmingham City WFCBirmingham Ci |