| 29 Aug 21 | r01        | Durham WFCDurham WFC | 2 - 1 | Watford WomenWatford Women |
| 29 Aug 21 | r01        | Blackburn Rovers LFCBlackburn Rov | 2 - 0 | Sheffield United WFCSheffield Uni |
| 29 Aug 21 | r01        | Coventry United LFCCoventry Unit | 0 - 1 | Sunderland WomenSunderland Wo |
| 29 Aug 21 | r01        | Crystal Palace FC WomenCrystal Palac | 4 - 3 | Bristol City WFCBristol City |
| 29 Aug 21 | r01        | Liverpool FC WomenLiverpool FC | 0 - 1 | London City LionessesLondon City L |
| |
| 04 Sep 21 | r02        | Watford WomenWatford Women | 2 - 3 | Liverpool FC WomenLiverpool FC |
| 05 Sep 21 | r02        | Charlton Athletic WFCCharlton Athl | 3 - 1 | Coventry United LFCCoventry Unit |
| 05 Sep 21 | r02        | London City LionessesLondon City L | 2 - 1 | Crystal Palace FC WomenCrystal Palac |
| 05 Sep 21 | r02        | Sheffield United WFCSheffield Uni | 3 - 1 | Durham WFCDurham WFC |
| 05 Sep 21 | r02        | Sunderland WomenSunderland Wo | 2 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 05 Sep 21 | r02        | Bristol City WFCBristol City | 2 - 1 | Lewes FC WomenLewes FC Wome |
| |
| 12 Sep 21 | r03        | Durham WFCDurham WFC | 2 - 0 | Charlton Athletic WFCCharlton Athl |
| 12 Sep 21 | r03        | Blackburn Rovers LFCBlackburn Rov | 3 - 1 | Watford WomenWatford Women |
| 12 Sep 21 | r03        | Coventry United LFCCoventry Unit | 0 - 3 | Sheffield United WFCSheffield Uni |
| 12 Sep 21 | r03        | Crystal Palace FC WomenCrystal Palac | 1 - 1 | Sunderland WomenSunderland Wo |
| 12 Sep 21 | r03        | Lewes FC WomenLewes FC Wome | 1 - 0 | London City LionessesLondon City L |
| 12 Sep 21 | r03        | Liverpool FC WomenLiverpool FC | 0 - 0 | Bristol City WFCBristol City |
| |
| 26 Sep 21 | r04        | Bristol City WFCBristol City | 0 - 2 | Durham WFCDurham WFC |
| 26 Sep 21 | r04        | Charlton Athletic WFCCharlton Athl | 2 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 26 Sep 21 | r04        | Liverpool FC WomenLiverpool FC | 2 - 1 | Crystal Palace FC WomenCrystal Palac |
| 26 Sep 21 | r04        | London City LionessesLondon City L | 2 - 2 | Coventry United LFCCoventry Unit |
| 26 Sep 21 | r04        | Sheffield United WFCSheffield Uni | 3 - 0 | Watford WomenWatford Women |
| 26 Sep 21 | r04        | Sunderland WomenSunderland Wo | 1 - 1 | Lewes FC WomenLewes FC Wome |
| |
| 02 Oct 21 | r05        | Watford WomenWatford Women | 0 - 4 | Charlton Athletic WFCCharlton Athl |
| 03 Oct 21 | r05        | Blackburn Rovers LFCBlackburn Rov | 1 - 2 | London City LionessesLondon City L |
| 03 Oct 21 | r05        | Durham WFCDurham WFC | 2 - 0 | Lewes FC WomenLewes FC Wome |
| 03 Oct 21 | r05        | Coventry United LFCCoventry Unit | 0 - 2 | Liverpool FC WomenLiverpool FC |
| 03 Oct 21 | r05        | Crystal Palace FC WomenCrystal Palac | 0 - 0 | Sheffield United WFCSheffield Uni |
| 03 Oct 21 | r05        | Bristol City WFCBristol City | 2 - 1 | Sunderland WomenSunderland Wo |
| |
| 09 Oct 21 | r06        | Sheffield United WFCSheffield Uni | 0 - 2 | Liverpool FC WomenLiverpool FC |
| 10 Oct 21 | r06        | Lewes FC WomenLewes FC Wome | 1 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 10 Oct 21 | r06        | Sunderland WomenSunderland Wo | 0 - 2 | Durham WFCDurham WFC |
| 10 Oct 21 | r06        | Charlton Athletic WFCCharlton Athl | 2 - 1 | Bristol City WFCBristol City |
| 10 Oct 21 | r06        | Coventry United LFCCoventry Unit | 2 - 3 | Crystal Palace FC WomenCrystal Palac |
| 10 Oct 21 | r06        | London City LionessesLondon City L | 2 - 1 | Watford WomenWatford Women |
| |
| 17 Oct 21 | r01        | Lewes FC WomenLewes FC Wome | 2 - 0 | Charlton Athletic WFCCharlton Athl |
| |
| 31 Oct 21 | r07        | Durham WFCDurham WFC | 1 - 0 | London City LionessesLondon City L |
| 31 Oct 21 | r07        | Liverpool FC WomenLiverpool FC | 2 - 0 | Lewes FC WomenLewes FC Wome |
| 31 Oct 21 | r07        | Blackburn Rovers LFCBlackburn Rov | 3 - 2 | Coventry United LFCCoventry Unit |
| 31 Oct 21 | r07        | Charlton Athletic WFCCharlton Athl | 0 - 1 | Sunderland WomenSunderland Wo |
| 31 Oct 21 | r07        | Watford WomenWatford Women | 2 - 2 | Crystal Palace FC WomenCrystal Palac |
| 31 Oct 21 | r07        | Bristol City WFCBristol City | 5 - 1 | Sheffield United WFCSheffield Uni |
| |
| 07 Nov 21 | r08        | Crystal Palace FC WomenCrystal Palac | 3 - 1 | Durham WFCDurham WFC |
| 07 Nov 21 | r08        | Lewes FC WomenLewes FC Wome | 1 - 2 | Watford WomenWatford Women |
| 07 Nov 21 | r08        | Liverpool FC WomenLiverpool FC | 0 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 07 Nov 21 | r08        | Sheffield United WFCSheffield Uni | 0 - 0 | Charlton Athletic WFCCharlton Athl |
| 07 Nov 21 | r08        | Sunderland WomenSunderland Wo | 0 - 2 | London City LionessesLondon City L |
| 08 Nov 21 | r08        | Coventry United LFCCoventry Unit | 1 - 1 | Bristol City WFCBristol City |
| |
| 14 Nov 21 | r09        | Durham WFCDurham WFC | 0 - 2 | Liverpool FC WomenLiverpool FC |
| 14 Nov 21 | r09        | Lewes FC WomenLewes FC Wome | 4 - 1 | Coventry United LFCCoventry Unit |
| 14 Nov 21 | r09        | London City LionessesLondon City L | 1 - 0 | Sheffield United WFCSheffield Uni |
| 14 Nov 21 | r09        | Crystal Palace FC WomenCrystal Palac | 3 - 2 | Charlton Athletic WFCCharlton Athl |
| 14 Nov 21 | r09        | Bristol City WFCBristol City | 3 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 14 Nov 21 | r09        | Watford WomenWatford Women | 1 - 1 | Sunderland WomenSunderland Wo |
| |
| 20 Nov 21 | r10        | Sunderland WomenSunderland Wo | 1 - 3 | Liverpool FC WomenLiverpool FC |
| 21 Nov 21 | r10        | Coventry United LFCCoventry Unit | 1 - 0 | Durham WFCDurham WFC |
| 21 Nov 21 | r10        | Sheffield United WFCSheffield Uni | 1 - 3 | Lewes FC WomenLewes FC Wome |
| 21 Nov 21 | r10        | Blackburn Rovers LFCBlackburn Rov | 1 - 2 | Crystal Palace FC WomenCrystal Palac |
| 21 Nov 21 | r10        | Charlton Athletic WFCCharlton Athl | 2 - 0 | London City LionessesLondon City L |
| 21 Nov 21 | r10        | Watford WomenWatford Women | 0 - 3 | Bristol City WFCBristol City |
| |
| 18 Dec 21 | r11        | Coventry United LFCCoventry Unit | 1 - 1 | Watford WomenWatford Women |
| 19 Dec 21 | r11        | Durham WFCDurham WFC | 3 - 1 | Blackburn Rovers LFCBlackburn Rov |
| 19 Dec 21 | r11        | Liverpool FC WomenLiverpool FC | P - P | Charlton Athletic WFCCharlton Athl |
| 19 Dec 21 | r11        | Sheffield United WFCSheffield Uni | P - P | Sunderland WomenSunderland Wo |
| |
| 09 Jan 22 | r12        | Lewes FC WomenLewes FC Wome | P - P | Durham WFCDurham WFC |
| 09 Jan 22 | r12        | Blackburn Rovers LFCBlackburn Rov | 0 - 6 | Liverpool FC WomenLiverpool FC |
| 09 Jan 22 | r12        | Charlton Athletic WFCCharlton Athl | 0 - 0 | Sheffield United WFCSheffield Uni |
| 09 Jan 22 | r12        | Sunderland WomenSunderland Wo | P - P | Crystal Palace FC WomenCrystal Palac |
| 09 Jan 22 | r12        | Bristol City WFCBristol City | P - P | Coventry United LFCCoventry Unit |
| |
| 16 Jan 22 | r13        | Durham WFCDurham WFC | 2 - 3 | Crystal Palace FC WomenCrystal Palac |
| 16 Jan 22 | r13        | Blackburn Rovers LFCBlackburn Rov | 0 - 1 | Bristol City WFCBristol City |
| 16 Jan 22 | r13        | Charlton Athletic WFCCharlton Athl | 1 - 0 | Lewes FC WomenLewes FC Wome |
| 16 Jan 22 | r13        | Liverpool FC WomenLiverpool FC | 1 - 0 | Watford WomenWatford Women |
| 16 Jan 22 | r13        | London City LionessesLondon City L | 3 - 1 | Sunderland WomenSunderland Wo |
| 16 Jan 22 | r13        | Sheffield United WFCSheffield Uni | 3 - 1 | Coventry United LFCCoventry Unit |
| |
| 23 Jan 22 | r14        | Durham WFCDurham WFC | 1 - 1 | Sheffield United WFCSheffield Uni |
| 23 Jan 22 | r14        | Coventry United LFCCoventry Unit | 0 - 1 | London City LionessesLondon City L |
| 23 Jan 22 | r14        | Crystal Palace FC WomenCrystal Palac | 0 - 4 | Liverpool FC WomenLiverpool FC |
| 23 Jan 22 | r14        | Lewes FC WomenLewes FC Wome | 2 - 0 | Sunderland WomenSunderland Wo |
| 23 Jan 22 | r14        | Bristol City WFCBristol City | 0 - 2 | Charlton Athletic WFCCharlton Athl |
| 23 Jan 22 | r14        | Watford WomenWatford Women | 0 - 0 | Blackburn Rovers LFCBlackburn Rov |
| |
| 30 Jan 22 | r11        | Crystal Palace FC WomenCrystal Palac | 3 - 1 | Lewes FC WomenLewes FC Wome |
| |
| 06 Feb 22 | r15        | London City LionessesLondon City L | 1 - 2 | Durham WFCDurham WFC |
| 06 Feb 22 | r15        | Charlton Athletic WFCCharlton Athl | 3 - 0 | Watford WomenWatford Women |
| 06 Feb 22 | r15        | Liverpool FC WomenLiverpool FC | 3 - 0 | Coventry United LFCCoventry Unit |
| 06 Feb 22 | r15        | Sunderland WomenSunderland Wo | 2 - 2 | Sheffield United WFCSheffield Uni |
| 06 Feb 22 | r15        | Bristol City WFCBristol City | 4 - 0 | Crystal Palace FC WomenCrystal Palac |
| |
| 13 Feb 22 | r16        | Durham WFCDurham WFC | 0 - 3 | Bristol City WFCBristol City |
| 13 Feb 22 | r16        | Sheffield United WFCSheffield Uni | 4 - 0 | Blackburn Rovers LFCBlackburn Rov |
| 13 Feb 22 | r16        | Coventry United LFCCoventry Unit | 1 - 1 | Charlton Athletic WFCCharlton Athl |
| 13 Feb 22 | r16        | Crystal Palace FC WomenCrystal Palac | 1 - 5 | London City LionessesLondon City L |
| 13 Feb 22 | r16        | Liverpool FC WomenLiverpool FC | 3 - 0 | Sunderland WomenSunderland Wo |
| 13 Feb 22 | r16        | Watford WomenWatford Women | 0 - 2 | Lewes FC WomenLewes FC Wome |
| |
| 27 Feb 22 | r15        | Blackburn Rovers LFCBlackburn Rov | 1 - 0 | Lewes FC WomenLewes FC Wome |
| |
| 27 Feb 22 | r11        | London City LionessesLondon City L | 2 - 3 | Bristol City WFCBristol City |
| |
| 05 Mar 22 | r17        | Watford WomenWatford Women | - | Sheffield United WFCSheffield Uni |
| 06 Mar 22 | r17        | Blackburn Rovers LFCBlackburn Rov | - | Durham WFCDurham WFC |
| 06 Mar 22 | r17        | Crystal Palace FC WomenCrystal Palac | - | Coventry United LFCCoventry Unit |
| 06 Mar 22 | r17        | Lewes FC WomenLewes FC Wome | - | Bristol City WFCBristol City |
| 06 Mar 22 | r17        | London City LionessesLondon City L | - | Liverpool FC WomenLiverpool FC |