| 27 Aug 21 | r01  | PSV Eindhoven WomenPSV Eindhoven | 3 - 0 | PEC Zwolle WomenPEC Zwolle Wo |
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| 12 Sep 21 | r03 | Excelsior WomenExcelsior Wom | 3 - 3 | PSV Eindhoven WomenPSV Eindhoven |
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| 26 Sep 21 | r04 | PSV Eindhoven WomenPSV Eindhoven | 2 - 1 | Twente WomenTwente Women |
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| 01 Oct 21 | r05 | ADO Den Haag WomenADO Den Haag | 1 - 0 | PSV Eindhoven WomenPSV Eindhoven |
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| 08 Oct 21 | r06 | PSV Eindhoven WomenPSV Eindhoven | 4 - 1 | Heerenveen WomenHeerenveen Wo |
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| 17 Oct 21 | r07 | Feyenoord WomenFeyenoord Wom | 2 - 1 | PSV Eindhoven WomenPSV Eindhoven |
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| 31 Oct 21 | r08 | PSV Eindhoven WomenPSV Eindhoven | 1 - 0 | VV Alkmaar WomenVV Alkmaar Wo |
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| 07 Nov 21 | r09 | Ajax WomenAjax Women | 5 - 1 | PSV Eindhoven WomenPSV Eindhoven |
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| 21 Nov 21 | r11 | PEC Zwolle WomenPEC Zwolle Wo | 1 - 1 | PSV Eindhoven WomenPSV Eindhoven |
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| 05 Dec 21 | r12 | PSV Eindhoven WomenPSV Eindhoven | 1 - 0 | Feyenoord WomenFeyenoord Wom |
| |
| 12 Dec 21 | r13 | Heerenveen WomenHeerenveen Wo | 0 - 1 | PSV Eindhoven WomenPSV Eindhoven |
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| 19 Dec 21 | r14 | PSV Eindhoven WomenPSV Eindhoven | 2 - 1 | ADO Den Haag WomenADO Den Haag |
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| 14 Jan 22 | r15 | PSV Eindhoven WomenPSV Eindhoven | 1 - 0 | Excelsior WomenExcelsior Wom |
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| 23 Jan 22 | r16 | Twente WomenTwente Women | 3 - 1 | PSV Eindhoven WomenPSV Eindhoven |
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| 11 Feb 22 | r18 | VV Alkmaar WomenVV Alkmaar Wo | 1 - 3 | PSV Eindhoven WomenPSV Eindhoven |
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| 28 Feb 22 | r17 | PSV Eindhoven WomenPSV Eindhoven | 1 - 2 | Ajax WomenAjax Women |
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| 04 Mar 22 | r19 | PSV Eindhoven WomenPSV Eindhoven | 0 - 1 | ADO Den Haag WomenADO Den Haag |
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| 27 Mar 22 | r21 | Ajax WomenAjax Women | 0 - 0 | PSV Eindhoven WomenPSV Eindhoven |
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| 01 Apr 22 | r22 | PSV Eindhoven WomenPSV Eindhoven | 1 - 0 | Heerenveen WomenHeerenveen Wo |
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| 22 Apr 22 | r23 | VV Alkmaar WomenVV Alkmaar Wo | 2 - 3 | PSV Eindhoven WomenPSV Eindhoven |
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| 29 Apr 22 | r24 | PEC Zwolle WomenPEC Zwolle Wo | 0 - 2 | PSV Eindhoven WomenPSV Eindhoven |
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| 08 May 22 | r25 | PSV Eindhoven WomenPSV Eindhoven | 2 - 1 | Feyenoord WomenFeyenoord Wom |
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| 14 May 22 | r26 | Twente WomenTwente Women | 3 - 0 | PSV Eindhoven WomenPSV Eindhoven |
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| 20 May 22 | r27 | PSV Eindhoven WomenPSV Eindhoven | 1 - 1 | Excelsior WomenExcelsior Wom |
Team 2021-2022 Schedules
ADO Den Haag Women
Ajax Women
AZ Vrouwen
De Graafschap Women
Feyenoord Women
Heerenveen Women
PEC Zwolle Women
PSV Eindhoven Women
Twente Women
Utrecht Women
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