| 04 Sep 21 | r01        | MusselburghMusselburgh | 33 - 13 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 11 Sep 21 | r02        | Glasgow Hutchesons AloysiGlasgow Hutch | 31 - 30 | HawickHawick |
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| 18 Sep 21 | r03        | CurrieCurrie | 45 - 0 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 25 Sep 21 | r04        | Glasgow Hutchesons AloysiGlasgow Hutch | 0 - 22 | MarrMarr |
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| 02 Oct 21 | r05        | Glasgow Hutchesons AloysiGlasgow Hutch | 34 - 10 | SelkirkSelkirk |
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| 09 Oct 21 | r06        | Edinburgh AcademicalsEdinburgh Aca | 35 - 12 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 16 Oct 21 | r07        | Glasgow Hutchesons AloysiGlasgow Hutch | 19 - 36 | Glasgow HawksGlasgow Hawks |
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| 06 Nov 21 | r10        | Glasgow Hutchesons AloysiGlasgow Hutch | 38 - 20 | MusselburghMusselburgh |
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| 20 Nov 21 | r08        | Aberdeen GSFPAberdeen GSFP | 14 - 21 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 27 Nov 21 | r11        | HawickHawick | 48 - 22 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 04 Dec 21 | r12        | Glasgow Hutchesons AloysiGlasgow Hutch | 15 - 20 | CurrieCurrie |
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| 11 Dec 21 | r13        | MarrMarr | 31 - 6 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 15 Jan 22 | r15        | Glasgow Hutchesons AloysiGlasgow Hutch | 20 - 28 | Edinburgh AcademicalsEdinburgh Aca |
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| 22 Jan 22 | r16        | Glasgow HawksGlasgow Hawks | 7 - 20 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 29 Jan 22 | r17        | Glasgow Hutchesons AloysiGlasgow Hutch | 64 - 27 | Aberdeen GSFPAberdeen GSFP |
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| 19 Feb 22 | r18        | Jed-ForestJed-Forest | 22 - 20 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 05 Mar 22 | r14        | SelkirkSelkirk | 24 - 27 | Glasgow Hutchesons AloysiGlasgow Hutch |
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| 12 Mar 22 | r09        | Glasgow Hutchesons AloysiGlasgow Hutch | 38 - 21 | Jed-ForestJed-Forest |