| 27 Aug 21 | r01  | Bourg-en-BresseBourg-en-Bres | 20 - 24 | US MontaubanUS Montauban |
| |
| 03 Sep 21 | r02 | US MontaubanUS Montauban | 25 - 16 | CarcassonneCarcassonne |
| |
| 10 Sep 21 | r03 | NarbonneNarbonne | 9 - 11 | US MontaubanUS Montauban |
| |
| 17 Sep 21 | r04 | US MontaubanUS Montauban | 37 - 11 | BéziersBéziers |
| |
| 24 Sep 21 | r05 | ColomiersColomiers | 41 - 14 | US MontaubanUS Montauban |
| |
| 08 Oct 21 | r06 | US MontaubanUS Montauban | 25 - 19 | VannesVannes |
| |
| 15 Oct 21 | r07 | Oyonnax RugbyOyonnax Rugby | 56 - 6 | US MontaubanUS Montauban |
| |
| 21 Oct 21 | r08 | US MontaubanUS Montauban | 21 - 18 | Mont-de-MarsanMont-de-Marsa |
| |
| 29 Oct 21 | r09 | US MontaubanUS Montauban | 37 - 22 | RouenRouen |
| |
| 04 Nov 21 | r10 | SU Agen Lot-et-GaronneSU Agen Lot-e | 41 - 17 | US MontaubanUS Montauban |
| |
| 19 Nov 21 | r11 | US MontaubanUS Montauban | 33 - 17 | NeversNevers |
| |
| 26 Nov 21 | r12 | ProvenceProvence | 37 - 15 | US MontaubanUS Montauban |
| |
| 03 Dec 21 | r13 | US MontaubanUS Montauban | 25 - 25 | FC GrenobleFC Grenoble |
| |
| 12 Dec 21 | r14 | Aviron BayonnaisAviron Bayonn | 41 - 24 | US MontaubanUS Montauban |
| |
| 17 Dec 21 | r15 | US MontaubanUS Montauban | 19 - 9 | AurillacAurillac |
| |
| 07 Jan 22 | r16 | US MontaubanUS Montauban | 22 - 8 | ColomiersColomiers |
| |
| 21 Jan 22 | r18 | US MontaubanUS Montauban | 27 - 27 | Bourg-en-BresseBourg-en-Bres |
| |
| 27 Jan 22 | r19 | CarcassonneCarcassonne | 31 - 6 | US MontaubanUS Montauban |
| |
| 11 Feb 22 | r20 | US MontaubanUS Montauban | 18 - 22 | ProvenceProvence |
| |
| 18 Feb 22 | r21 | VannesVannes | 22 - 18 | US MontaubanUS Montauban |
| |
| 25 Feb 22 | r22 | US MontaubanUS Montauban | 30 - 24 | Oyonnax RugbyOyonnax Rugby |
| |
| 04 Mar 22 | r23 | Mont-de-MarsanMont-de-Marsa | 27 - 23 | US MontaubanUS Montauban |
| |
| 10 Mar 22 | r24 | RouenRouen | 17 - 34 | US MontaubanUS Montauban |
| |
| 17 Mar 22 | r17 | BéziersBéziers | 33 - 21 | US MontaubanUS Montauban |
| |
| 01 Apr 22 | r25 | US MontaubanUS Montauban | 21 - 15 | SU Agen Lot-et-GaronneSU Agen Lot-e |
| |
| 08 Apr 22 | r26 | FC GrenobleFC Grenoble | 22 - 21 | US MontaubanUS Montauban |
| |
| 14 Apr 22 | r27 | US MontaubanUS Montauban | 23 - 33 | Aviron BayonnaisAviron Bayonn |
| |
| 22 Apr 22 | r28 | AurillacAurillac | 25 - 20 | US MontaubanUS Montauban |
| |
| 06 May 22 | r29 | US MontaubanUS Montauban | 48 - 40 | NarbonneNarbonne |
| |
| 12 May 22 | r30 | NeversNevers | 30 - 6 | US MontaubanUS Montauban |
Team 2021-2022 Schedules
Aurillac
Béziers
Biarritz Olympique
CA Brive
Colomiers
FC Grenoble
Narbonne
Nevers
Nissa Rugby
Oyonnax Rugby
Provence
Soyaux Angoulême XV Charente
SU Agen Lot-et-Garonne
US Dax
US Montauban
Valence Romans Drôme Rugby
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