| 27 Aug 21 | r01        | NarbonneNarbonne | 14 - 37 | Mont-de-MarsanMont-de-Marsa |
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| 03 Sep 21 | r02        | Mont-de-MarsanMont-de-Marsa | 48 - 13 | Bourg-en-BresseBourg-en-Bres |
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| 10 Sep 21 | r03        | CarcassonneCarcassonne | 22 - 26 | Mont-de-MarsanMont-de-Marsa |
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| 17 Sep 21 | r04        | Mont-de-MarsanMont-de-Marsa | 46 - 5 | VannesVannes |
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| 24 Sep 21 | r05        | Mont-de-MarsanMont-de-Marsa | 43 - 8 | SU Agen Lot-et-GaronneSU Agen Lot-e |
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| 08 Oct 21 | r06        | Oyonnax RugbyOyonnax Rugby | 36 - 19 | Mont-de-MarsanMont-de-Marsa |
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| 15 Oct 21 | r07        | Mont-de-MarsanMont-de-Marsa | 45 - 8 | RouenRouen |
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| 21 Oct 21 | r08        | US MontaubanUS Montauban | 21 - 18 | Mont-de-MarsanMont-de-Marsa |
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| 28 Oct 21 | r09        | Mont-de-MarsanMont-de-Marsa | 41 - 20 | NeversNevers |
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| 05 Nov 21 | r10        | Aviron BayonnaisAviron Bayonn | 14 - 33 | Mont-de-MarsanMont-de-Marsa |
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| 19 Nov 21 | r11        | Mont-de-MarsanMont-de-Marsa | 38 - 10 | AurillacAurillac |
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| 25 Nov 21 | r12        | BéziersBéziers | 22 - 32 | Mont-de-MarsanMont-de-Marsa |
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| 03 Dec 21 | r13        | Mont-de-MarsanMont-de-Marsa | 32 - 13 | ProvenceProvence |
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| 09 Dec 21 | r14        | FC GrenobleFC Grenoble | 32 - 19 | Mont-de-MarsanMont-de-Marsa |
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| 16 Dec 21 | r15        | Mont-de-MarsanMont-de-Marsa | 27 - 9 | ColomiersColomiers |
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| 07 Jan 22 | r16        | Mont-de-MarsanMont-de-Marsa | 25 - 10 | CarcassonneCarcassonne |
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| 13 Jan 22 | r17        | NeversNevers | 27 - 6 | Mont-de-MarsanMont-de-Marsa |
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| 21 Jan 22 | r18        | Mont-de-MarsanMont-de-Marsa | 33 - 6 | NarbonneNarbonne |
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| 28 Jan 22 | r19        | VannesVannes | 33 - 10 | Mont-de-MarsanMont-de-Marsa |
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| 11 Feb 22 | r20        | RouenRouen | 13 - 19 | Mont-de-MarsanMont-de-Marsa |
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| 18 Feb 22 | r21        | Mont-de-MarsanMont-de-Marsa | 27 - 20 | Oyonnax RugbyOyonnax Rugby |
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| 25 Feb 22 | r22        | SU Agen Lot-et-GaronneSU Agen Lot-e | 27 - 30 | Mont-de-MarsanMont-de-Marsa |
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| 04 Mar 22 | r23        | Mont-de-MarsanMont-de-Marsa | 27 - 23 | US MontaubanUS Montauban |
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| 10 Mar 22 | r24        | Bourg-en-BresseBourg-en-Bres | 13 - 40 | Mont-de-MarsanMont-de-Marsa |
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| 01 Apr 22 | r25        | Mont-de-MarsanMont-de-Marsa | 15 - 13 | Aviron BayonnaisAviron Bayonn |
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| 08 Apr 22 | r26        | AurillacAurillac | 14 - 32 | Mont-de-MarsanMont-de-Marsa |
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| 15 Apr 22 | r27        | Mont-de-MarsanMont-de-Marsa | 34 - 13 | BéziersBéziers |
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| 22 Apr 22 | r28        | ColomiersColomiers | 27 - 23 | Mont-de-MarsanMont-de-Marsa |
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| 06 May 22 | r29        | Mont-de-MarsanMont-de-Marsa | 22 - 12 | FC GrenobleFC Grenoble |
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| 12 May 22 | r30        | ProvenceProvence | 26 - 13 | Mont-de-MarsanMont-de-Marsa |
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| 29 May 22 | r00        | Mont-de-MarsanMont-de-Marsa | 26 - 15 | NeversNevers |
| 05 Jun 22 | r00        | Mont-de-MarsanMont-de-Marsa | 20 - 49 | Aviron BayonnaisAviron Bayonn |