| 08 Jan 22 | r01        | Kobelco Kobe SteelersKobelco Kobe | 23 - 24 | Shining Arcs Tokyo-Bay UrShining Arcs |
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| 15 Jan 22 | r02        | Yokohama Canon EaglesYokohama Cano | 55 - 21 | Kobelco Kobe SteelersKobelco Kobe |
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| 22 Jan 22 | r03        | Kobelco Kobe SteelersKobelco Kobe | 27 - 22 | Kubota Spears Funabashi TKubota Spears |
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| 29 Jan 22 | r04        | Kobelco Kobe SteelersKobelco Kobe | 37 - 41 | Saitama Wild KnightsSaitama Wild |
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| 06 Feb 22 | r05        | Green Rockets TokatsuGreen Rockets | 17 - 48 | Kobelco Kobe SteelersKobelco Kobe |
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| 19 Feb 22 | r06        | Toyota VerblitzToyota Verbli | 21 - 0 | Kobelco Kobe SteelersKobelco Kobe |
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| 26 Feb 22 | r07        | Kobelco Kobe SteelersKobelco Kobe | 0 - 21 | NTT DoCoMo Red HurricanesNTT DoCoMo Re |
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| 04 Mar 22 | r08        | Tokyo SungoliathTokyo Sungoli | 56 - 17 | Kobelco Kobe SteelersKobelco Kobe |
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| 12 Mar 22 | r09        | Kobelco Kobe SteelersKobelco Kobe | 56 - 21 | Black Rams TokyoBlack Rams To |
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| 20 Mar 22 | r10        | Shizuoka Blue RevsShizuoka Blue | 0 - 21 | Kobelco Kobe SteelersKobelco Kobe |
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| 27 Mar 22 | r11        | Kobelco Kobe SteelersKobelco Kobe | 35 - 46 | Toshiba Brave Lupus TokyoToshiba Brave |
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| 10 Apr 22 | r12        | Kobelco Kobe SteelersKobelco Kobe | 57 - 28 | Green Rockets TokatsuGreen Rockets |
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| 16 Apr 22 | r13        | Saitama Wild KnightsSaitama Wild | 37 - 31 | Kobelco Kobe SteelersKobelco Kobe |
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| 23 Apr 22 | r14        | Kubota Spears Funabashi TKubota Spears | 40 - 32 | Kobelco Kobe SteelersKobelco Kobe |
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| 01 May 22 | r15        | Kobelco Kobe SteelersKobelco Kobe | 42 - 33 | Yokohama Canon EaglesYokohama Cano |
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| 08 May 22 | r16        | Shining Arcs Tokyo-Bay UrShining Arcs | 34 - 74 | Kobelco Kobe SteelersKobelco Kobe |