| 17 Oct 20 | r02        | Exeter Chiefs WomenExeter Chiefs | 22 - 24 | Bristol Bears WomenBristol Bears |
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| 24 Oct 20 | r03        | Bristol Bears WomenBristol Bears | 5 - 12 | Loughborough LightningLoughborough |
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| 31 Oct 20 | r01        | Bristol Bears WomenBristol Bears | 10 - 64 | Wasps WomenWasps Women |
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| 07 Nov 20 | r04        | Sale Sharks WomenSale Sharks W | 18 - 40 | Bristol Bears WomenBristol Bears |
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| 14 Nov 20 | r05        | Bristol Bears WomenBristol Bears | 3 - 28 | Gloucester-Hartpury WomenGloucester-Ha |
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| 28 Nov 20 | r06        | Bristol Bears WomenBristol Bears | 10 - 36 | Saracens WomenSaracens Wome |
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| 05 Dec 20 | r07        | Harlequins WomenHarlequins Wo | 61 - 17 | Bristol Bears WomenBristol Bears |
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| 12 Dec 20 | r08        | Bristol Bears WomenBristol Bears | 12 - 15 | Worcester Warriors WomenWorcester War |
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| 19 Dec 20 | r09        | DMP Durham SharksDMP Durham Sh | 3 - 50 | Bristol Bears WomenBristol Bears |
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| 09 Jan 21 | r10        | Bristol Bears WomenBristol Bears | 27 - 31 | Exeter Chiefs WomenExeter Chiefs |
| 06 Feb 21 | r10        | Loughborough LightningLoughborough | 42 - 14 | Bristol Bears WomenBristol Bears |
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| 13 Feb 21 | r12        | Bristol Bears WomenBristol Bears | 22 - 12 | Sale Sharks WomenSale Sharks W |
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| 27 Feb 21 | r13        | Gloucester-Hartpury WomenGloucester-Ha | 36 - 0 | Bristol Bears WomenBristol Bears |
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| 06 Mar 21 | r14        | Saracens WomenSaracens Wome | 53 - 7 | Bristol Bears WomenBristol Bears |
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| 20 Mar 21 | r15        | Bristol Bears WomenBristol Bears | 7 - 62 | Harlequins WomenHarlequins Wo |
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| 28 Mar 21 | r16        | Worcester Warriors WomenWorcester War | 29 - 21 | Bristol Bears WomenBristol Bears |
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| 17 Apr 21 | r17        | Bristol Bears WomenBristol Bears | 17 - 34 | DMP Durham SharksDMP Durham Sh |
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| 08 May 21 | r18        | Wasps WomenWasps Women | 62 - 12 | Bristol Bears WomenBristol Bears |