| 04 Sep 21 | r01        | Bristol Bears WomenBristol Bears | 38 - 21 | Exeter Chiefs WomenExeter Chiefs |
| 04 Sep 21 | r01        | Sale Sharks WomenSale Sharks W | 24 - 29 | Worcester Warriors WomenWorcester War |
| 04 Sep 21 | r01        | Wasps WomenWasps Women | 20 - 26 | Saracens WomenSaracens Wome |
| 04 Sep 21 | r01        | Gloucester-Hartpury WomenGloucester-Ha | 84 - 0 | DMP Durham SharksDMP Durham Sh |
| 05 Sep 21 | r01        | Harlequins WomenHarlequins Wo | 50 - 15 | Loughborough LightningLoughborough |
| |
| 11 Sep 21 | r02        | DMP Durham SharksDMP Durham Sh | 5 - 75 | Saracens WomenSaracens Wome |
| 11 Sep 21 | r02        | Gloucester-Hartpury WomenGloucester-Ha | 17 - 24 | Bristol Bears WomenBristol Bears |
| 11 Sep 21 | r02        | Worcester Warriors WomenWorcester War | 31 - 66 | Harlequins WomenHarlequins Wo |
| 12 Sep 21 | r02        | Exeter Chiefs WomenExeter Chiefs | 54 - 0 | Sale Sharks WomenSale Sharks W |
| 12 Sep 21 | r02        | Loughborough LightningLoughborough | 0 - 29 | Wasps WomenWasps Women |
| |
| 18 Sep 21 | r03        | Bristol Bears WomenBristol Bears | 115 - 0 | DMP Durham SharksDMP Durham Sh |
| 18 Sep 21 | r03        | Saracens WomenSaracens Wome | 38 - 7 | Loughborough LightningLoughborough |
| 18 Sep 21 | r03        | Wasps WomenWasps Women | 26 - 22 | Worcester Warriors WomenWorcester War |
| 18 Sep 21 | r03        | Sale Sharks WomenSale Sharks W | 21 - 45 | Gloucester-Hartpury WomenGloucester-Ha |
| 18 Sep 21 | r03        | Harlequins WomenHarlequins Wo | 12 - 24 | Exeter Chiefs WomenExeter Chiefs |
| |
| 02 Oct 21 | r04        | Bristol Bears WomenBristol Bears | 27 - 17 | Sale Sharks WomenSale Sharks W |
| 02 Oct 21 | r04        | Exeter Chiefs WomenExeter Chiefs | 23 - 13 | Wasps WomenWasps Women |
| 02 Oct 21 | r04        | DMP Durham SharksDMP Durham Sh | 0 - 59 | Loughborough LightningLoughborough |
| 02 Oct 21 | r04        | Gloucester-Hartpury WomenGloucester-Ha | 18 - 21 | Harlequins WomenHarlequins Wo |
| 02 Oct 21 | r04        | Worcester Warriors WomenWorcester War | 5 - 34 | Saracens WomenSaracens Wome |
| |
| 09 Oct 21 | r05        | Harlequins WomenHarlequins Wo | 5 - 24 | Bristol Bears WomenBristol Bears |
| 09 Oct 21 | r05        | Loughborough LightningLoughborough | 14 - 18 | Worcester Warriors WomenWorcester War |
| 09 Oct 21 | r05        | DMP Durham SharksDMP Durham Sh | 0 - 31 | Sale Sharks WomenSale Sharks W |
| 10 Oct 21 | r05        | Saracens WomenSaracens Wome | 32 - 19 | Exeter Chiefs WomenExeter Chiefs |
| 10 Oct 21 | r05        | Wasps WomenWasps Women | 34 - 25 | Gloucester-Hartpury WomenGloucester-Ha |
| |
| 27 Nov 21 | r06        | Sale Sharks WomenSale Sharks W | 10 - 36 | Harlequins WomenHarlequins Wo |
| 27 Nov 21 | r06        | Exeter Chiefs WomenExeter Chiefs | 14 - 7 | Loughborough LightningLoughborough |
| 27 Nov 21 | r06        | Gloucester-Hartpury WomenGloucester-Ha | 21 - 24 | Saracens WomenSaracens Wome |
| 28 Nov 21 | r06        | Bristol Bears WomenBristol Bears | 36 - 17 | Wasps WomenWasps Women |
| |
| 04 Dec 21 | r07        | Saracens WomenSaracens Wome | 17 - 12 | Bristol Bears WomenBristol Bears |
| 04 Dec 21 | r07        | Wasps WomenWasps Women | 22 - 8 | Sale Sharks WomenSale Sharks W |
| 04 Dec 21 | r07        | Harlequins WomenHarlequins Wo | 69 - 7 | DMP Durham SharksDMP Durham Sh |
| 04 Dec 21 | r07        | Gloucester-Hartpury WomenGloucester-Ha | 31 - 33 | Loughborough LightningLoughborough |
| 04 Dec 21 | r07        | Worcester Warriors WomenWorcester War | 12 - 29 | Exeter Chiefs WomenExeter Chiefs |
| |
| 11 Dec 21 | r08        | Exeter Chiefs WomenExeter Chiefs | 8 - 10 | Gloucester-Hartpury WomenGloucester-Ha |
| 11 Dec 21 | r08        | Loughborough LightningLoughborough | 27 - 0 | Sale Sharks WomenSale Sharks W |
| 11 Dec 21 | r08        | Worcester Warriors WomenWorcester War | 12 - 14 | Bristol Bears WomenBristol Bears |
| 11 Dec 21 | r08        | Wasps WomenWasps Women | 70 - 0 | DMP Durham SharksDMP Durham Sh |
| 12 Dec 21 | r08        | Saracens WomenSaracens Wome | 17 - 36 | Harlequins WomenHarlequins Wo |
| |
| 18 Dec 21 | r09        | DMP Durham SharksDMP Durham Sh | 0 - 88 | Exeter Chiefs WomenExeter Chiefs |
| 18 Dec 21 | r09        | Loughborough LightningLoughborough | 17 - 14 | Bristol Bears WomenBristol Bears |
| 19 Dec 21 | r09        | Worcester Warriors WomenWorcester War | 10 - 36 | Gloucester-Hartpury WomenGloucester-Ha |
| 27 Dec 21 | r09        | Harlequins WomenHarlequins Wo | 29 - 5 | Wasps WomenWasps Women |
| |
| 08 Jan 22 | r10        | Bristol Bears WomenBristol Bears | 14 - 36 | Gloucester-Hartpury WomenGloucester-Ha |
| 08 Jan 22 | r10        | Sale Sharks WomenSale Sharks W | 7 - 43 | Exeter Chiefs WomenExeter Chiefs |
| 09 Jan 22 | r10        | Saracens WomenSaracens Wome | 104 - 0 | DMP Durham SharksDMP Durham Sh |
| |
| 15 Jan 22 | r11        | DMP Durham SharksDMP Durham Sh | 7 - 48 | Bristol Bears WomenBristol Bears |
| 15 Jan 22 | r11        | Gloucester-Hartpury WomenGloucester-Ha | 17 - 3 | Sale Sharks WomenSale Sharks W |
| 15 Jan 22 | r11        | Loughborough LightningLoughborough | 12 - 27 | Saracens WomenSaracens Wome |
| 16 Jan 22 | r11        | Worcester Warriors WomenWorcester War | - | Wasps WomenWasps Women |
| 16 Jan 22 | r11        | Exeter Chiefs WomenExeter Chiefs | 18 - 17 | Harlequins WomenHarlequins Wo |
| |
| 22 Jan 22 | r10        | Wasps WomenWasps Women | 22 - 41 | Loughborough LightningLoughborough |
| |
| 22 Jan 22 | r09        | Sale Sharks WomenSale Sharks W | 26 - 41 | Saracens WomenSaracens Wome |
| |
| 22 Jan 22 | r06        | DMP Durham SharksDMP Durham Sh | 5 - 74 | Worcester Warriors WomenWorcester War |
| |
| 29 Jan 22 | r12        | Wasps WomenWasps Women | 15 - 15 | Exeter Chiefs WomenExeter Chiefs |
| 29 Jan 22 | r12        | Loughborough LightningLoughborough | 58 - 5 | DMP Durham SharksDMP Durham Sh |
| 29 Jan 22 | r12        | Saracens WomenSaracens Wome | 39 - 28 | Worcester Warriors WomenWorcester War |
| 29 Jan 22 | r12        | Harlequins WomenHarlequins Wo | 26 - 12 | Gloucester-Hartpury WomenGloucester-Ha |
| 30 Jan 22 | r12        | Sale Sharks WomenSale Sharks W | 5 - 36 | Bristol Bears WomenBristol Bears |
| |
| 05 Feb 22 | r13        | Bristol Bears WomenBristol Bears | 12 - 10 | Worcester Warriors WomenWorcester War |
| 05 Feb 22 | r13        | DMP Durham SharksDMP Durham Sh | 0 - 46 | Wasps WomenWasps Women |
| 05 Feb 22 | r13        | Gloucester-Hartpury WomenGloucester-Ha | 32 - 36 | Exeter Chiefs WomenExeter Chiefs |
| 05 Feb 22 | r13        | Harlequins WomenHarlequins Wo | 8 - 22 | Saracens WomenSaracens Wome |
| 05 Feb 22 | r13        | Sale Sharks WomenSale Sharks W | 3 - 32 | Loughborough LightningLoughborough |
| |
| 12 Feb 22 | r10        | Harlequins WomenHarlequins Wo | 42 - 15 | Worcester Warriors WomenWorcester War |
| |
| 19 Feb 22 | r14        | Wasps WomenWasps Women | 5 - 7 | Bristol Bears WomenBristol Bears |
| 19 Feb 22 | r14        | Worcester Warriors WomenWorcester War | 57 - 17 | DMP Durham SharksDMP Durham Sh |
| 19 Feb 22 | r14        | Saracens WomenSaracens Wome | 35 - 20 | Gloucester-Hartpury WomenGloucester-Ha |
| 19 Feb 22 | r14        | Loughborough LightningLoughborough | 28 - 25 | Exeter Chiefs WomenExeter Chiefs |
| 20 Feb 22 | r14        | Harlequins WomenHarlequins Wo | 40 - 8 | Sale Sharks WomenSale Sharks W |
| |
| 26 Feb 22 | r15        | Loughborough LightningLoughborough | 19 - 19 | Gloucester-Hartpury WomenGloucester-Ha |
| 26 Feb 22 | r15        | DMP Durham SharksDMP Durham Sh | 5 - 48 | Harlequins WomenHarlequins Wo |
| 26 Feb 22 | r15        | Exeter Chiefs WomenExeter Chiefs | 60 - 7 | Worcester Warriors WomenWorcester War |
| 26 Feb 22 | r15        | Sale Sharks WomenSale Sharks W | 14 - 53 | Wasps WomenWasps Women |
| 27 Feb 22 | r15        | Bristol Bears WomenBristol Bears | 26 - 30 | Saracens WomenSaracens Wome |
| |
| 05 Mar 22 | r16        | Wasps WomenWasps Women | 30 - 14 | Harlequins WomenHarlequins Wo |
| 05 Mar 22 | r16        | Bristol Bears WomenBristol Bears | 26 - 26 | Loughborough LightningLoughborough |
| 05 Mar 22 | r16        | Exeter Chiefs WomenExeter Chiefs | 90 - 7 | DMP Durham SharksDMP Durham Sh |
| 05 Mar 22 | r16        | Gloucester-Hartpury WomenGloucester-Ha | 15 - 12 | Worcester Warriors WomenWorcester War |
| 06 Mar 22 | r16        | Saracens WomenSaracens Wome | 41 - 33 | Sale Sharks WomenSale Sharks W |
| |
| 07 May 22 | r17        | Exeter Chiefs WomenExeter Chiefs | 54 - 12 | Saracens WomenSaracens Wome |
| 07 May 22 | r17        | Gloucester-Hartpury WomenGloucester-Ha | 36 - 7 | Wasps WomenWasps Women |
| 07 May 22 | r17        | Sale Sharks WomenSale Sharks W | 57 - 5 | DMP Durham SharksDMP Durham Sh |
| 07 May 22 | r17        | Worcester Warriors WomenWorcester War | 34 - 24 | Loughborough LightningLoughborough |
| 07 May 22 | r17        | Bristol Bears WomenBristol Bears | 26 - 43 | Harlequins WomenHarlequins Wo |
| |
| 14 May 22 | r18        | DMP Durham SharksDMP Durham Sh | 0 - 67 | Gloucester-Hartpury WomenGloucester-Ha |
| 14 May 22 | r18        | Exeter Chiefs WomenExeter Chiefs | 29 - 26 | Bristol Bears WomenBristol Bears |
| 14 May 22 | r18        | Loughborough LightningLoughborough | 22 - 17 | Harlequins WomenHarlequins Wo |
| 14 May 22 | r18        | Saracens WomenSaracens Wome | 31 - 26 | Wasps WomenWasps Women |
| 14 May 22 | r18        | Worcester Warriors WomenWorcester War | 51 - 26 | Sale Sharks WomenSale Sharks W |
| |
| 22 May 22 | r00        | Saracens WomenSaracens Wome | 30 - 10 | Harlequins WomenHarlequins Wo |
| 22 May 22 | r00        | Exeter Chiefs WomenExeter Chiefs | 28 - 24 | Bristol Bears WomenBristol Bears |
| 03 Jun 22 | r00        | Saracens WomenSaracens Wome | 43 - 21 | Exeter Chiefs WomenExeter Chiefs |