| 05 Sep 21 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 8 | Sudbury WolvesSudbury Wolve |
| 26 Sep 21 | r00        | Soo GreyhoundsSoo Greyhound | 1 - 5 | Sudbury WolvesSudbury Wolve |
| 02 Oct 21 | r00        | Sudbury WolvesSudbury Wolve | 3 - 9 | Soo GreyhoundsSoo Greyhound |
| 09 Oct 21 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 1 | North Bay BattalionNorth Bay Bat |
| 10 Oct 21 | r00        | Soo GreyhoundsSoo Greyhound | 3 - 6 | Sudbury WolvesSudbury Wolve |
| 15 Oct 21 | r00        | Barrie ColtsBarrie Colts | 3 - 6 | Soo GreyhoundsSoo Greyhound |
| 16 Oct 21 | r00        | Guelph StormGuelph Storm | 2 - 4 | Soo GreyhoundsSoo Greyhound |
| 17 Oct 21 | r00        | Owen Sound AttackOwen Sound At | 5 - 3 | Soo GreyhoundsSoo Greyhound |
| 21 Oct 21 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 3 | Sudbury WolvesSudbury Wolve |
| 23 Oct 21 | r00        | Soo GreyhoundsSoo Greyhound | 8 - 5 | North Bay BattalionNorth Bay Bat |
| 24 Oct 21 | r00        | Soo GreyhoundsSoo Greyhound | 2 - 4 | North Bay BattalionNorth Bay Bat |
| 28 Oct 21 | r00        | Soo GreyhoundsSoo Greyhound | 3 - 1 | Kitchener RangersKitchener Ran |
| 30 Oct 21 | r00        | Kitchener RangersKitchener Ran | 4 - 5 | Soo GreyhoundsSoo Greyhound |
| 31 Oct 21 | r00        | Guelph StormGuelph Storm | 4 - 1 | Soo GreyhoundsSoo Greyhound |
| 03 Nov 21 | r00        | Soo GreyhoundsSoo Greyhound | 8 - 4 | Saginaw SpiritSaginaw Spiri |
| 05 Nov 21 | r00        | Soo GreyhoundsSoo Greyhound | 9 - 4 | Guelph StormGuelph Storm |
| 06 Nov 21 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 6 | Guelph StormGuelph Storm |
| 13 Nov 21 | r00        | London KnightsLondon Knight | 7 - 4 | Soo GreyhoundsSoo Greyhound |
| 14 Nov 21 | r00        | Windsor SpitfiresWindsor Spitf | 3 - 4 | Soo GreyhoundsSoo Greyhound |
| 18 Nov 21 | r00        | Saginaw SpiritSaginaw Spiri | 4 - 1 | Soo GreyhoundsSoo Greyhound |
| 21 Nov 21 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 4 | Erie OttersErie Otters |
| 26 Nov 21 | r00        | Erie OttersErie Otters | 5 - 3 | Soo GreyhoundsSoo Greyhound |
| 27 Nov 21 | r00        | Kitchener RangersKitchener Ran | 5 - 4 | Soo GreyhoundsSoo Greyhound |
| 28 Nov 21 | r00        | Sarnia StingSarnia Sting | 0 - 2 | Soo GreyhoundsSoo Greyhound |
| 04 Dec 21 | r00        | Soo GreyhoundsSoo Greyhound | 7 - 2 | Guelph StormGuelph Storm |
| 05 Dec 21 | r00        | Soo GreyhoundsSoo Greyhound | 7 - 2 | Saginaw SpiritSaginaw Spiri |
| 10 Dec 21 | r00        | North Bay BattalionNorth Bay Bat | 5 - 4 | Soo GreyhoundsSoo Greyhound |
| 17 Dec 21 | r00        | Windsor SpitfiresWindsor Spitf | 4 - 3 | Soo GreyhoundsSoo Greyhound |
| 18 Dec 21 | r00        | Kitchener RangersKitchener Ran | 3 - 4 | Soo GreyhoundsSoo Greyhound |
| 30 Dec 21 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 4 | Sudbury WolvesSudbury Wolve |
| 31 Dec 21 | r00        | Saginaw SpiritSaginaw Spiri | 2 - 1 | Soo GreyhoundsSoo Greyhound |
| 02 Jan 22 | r00        | Sudbury WolvesSudbury Wolve | 2 - 4 | Soo GreyhoundsSoo Greyhound |
| 05 Jan 22 | r00        | Sudbury WolvesSudbury Wolve | 1 - 6 | Soo GreyhoundsSoo Greyhound |
| 09 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 2 - 5 | Windsor SpitfiresWindsor Spitf |
| 09 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 10 | Windsor SpitfiresWindsor Spitf |
| 16 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 2 | Owen Sound AttackOwen Sound At |
| 16 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 6 - 1 | Owen Sound AttackOwen Sound At |
| 21 Jan 22 | r00        | Windsor SpitfiresWindsor Spitf | 3 - 2 | Soo GreyhoundsSoo Greyhound |
| 22 Jan 22 | r00        | Guelph StormGuelph Storm | 2 - 4 | Soo GreyhoundsSoo Greyhound |
| 27 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 1 | Saginaw SpiritSaginaw Spiri |
| 29 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 5 | Flint FirebirdsFlint Firebir |
| 30 Jan 22 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 3 | Barrie ColtsBarrie Colts |
| 04 Feb 22 | r00        | North Bay BattalionNorth Bay Bat | 5 - 2 | Soo GreyhoundsSoo Greyhound |
| 05 Feb 22 | r00        | North Bay BattalionNorth Bay Bat | 5 - 4 | Soo GreyhoundsSoo Greyhound |
| 06 Feb 22 | r00        | Sudbury WolvesSudbury Wolve | 3 - 6 | Soo GreyhoundsSoo Greyhound |
| 12 Feb 22 | r00        | Soo GreyhoundsSoo Greyhound | 0 - 3 | Sarnia StingSarnia Sting |
| 13 Feb 22 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 3 | Sarnia StingSarnia Sting |
| 17 Feb 22 | r00        | Soo GreyhoundsSoo Greyhound | 2 - 1 | Flint FirebirdsFlint Firebir |
| 19 Feb 22 | r00        | London KnightsLondon Knight | 8 - 5 | Soo GreyhoundsSoo Greyhound |
| 20 Feb 22 | r00        | Owen Sound AttackOwen Sound At | 1 - 4 | Soo GreyhoundsSoo Greyhound |
| 24 Feb 22 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 6 | Sudbury WolvesSudbury Wolve |
| 26 Feb 22 | r00        | Soo GreyhoundsSoo Greyhound | 6 - 3 | London KnightsLondon Knight |
| 27 Feb 22 | r00        | Soo GreyhoundsSoo Greyhound | 0 - 3 | London KnightsLondon Knight |
| 05 Mar 22 | r00        | Sarnia StingSarnia Sting | 6 - 5 | Soo GreyhoundsSoo Greyhound |
| 06 Mar 22 | r00        | Windsor SpitfiresWindsor Spitf | 7 - 3 | Soo GreyhoundsSoo Greyhound |
| 10 Mar 22 | r00        | Sudbury WolvesSudbury Wolve | 2 - 6 | Soo GreyhoundsSoo Greyhound |
| 12 Mar 22 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 3 | Kitchener RangersKitchener Ran |
| 13 Mar 22 | r00        | Soo GreyhoundsSoo Greyhound | 7 - 4 | Kitchener RangersKitchener Ran |
| 16 Mar 22 | r00        | Sarnia StingSarnia Sting | 4 - 0 | Soo GreyhoundsSoo Greyhound |
| 18 Mar 22 | r00        | Flint FirebirdsFlint Firebir | 7 - 8 | Soo GreyhoundsSoo Greyhound |
| 19 Mar 22 | r00        | Saginaw SpiritSaginaw Spiri | 0 - 3 | Soo GreyhoundsSoo Greyhound |
| 23 Mar 22 | r00        | Soo GreyhoundsSoo Greyhound | P - P | Flint FirebirdsFlint Firebir |
| 26 Mar 22 | r00        | Soo GreyhoundsSoo Greyhound | 3 - 5 | Windsor SpitfiresWindsor Spitf |
| 27 Mar 22 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 5 | Windsor SpitfiresWindsor Spitf |
| 30 Mar 22 | r00        | Saginaw SpiritSaginaw Spiri | 2 - 1 | Soo GreyhoundsSoo Greyhound |
| 02 Apr 22 | r00        | Soo GreyhoundsSoo Greyhound | 9 - 3 | Saginaw SpiritSaginaw Spiri |
| 05 Apr 22 | r00        | Soo GreyhoundsSoo Greyhound | 8 - 2 | Sarnia StingSarnia Sting |
| 09 Apr 22 | r00        | Sudbury WolvesSudbury Wolve | 4 - 8 | Soo GreyhoundsSoo Greyhound |
| 10 Apr 22 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 1 | Sudbury WolvesSudbury Wolve |
| 14 Apr 22 | r00        | Soo GreyhoundsSoo Greyhound | 6 - 4 | Sudbury WolvesSudbury Wolve |
| 16 Apr 22 | r00        | Flint FirebirdsFlint Firebir | 3 - 6 | Soo GreyhoundsSoo Greyhound |
| 17 Apr 22 | r00        | Flint FirebirdsFlint Firebir | 6 - 4 | Soo GreyhoundsSoo Greyhound |
| 22 Apr 22 | r00        | Soo GreyhoundsSoo Greyhound | 3 - 0 | Guelph StormGuelph Storm |
| 24 Apr 22 | r00        | Soo GreyhoundsSoo Greyhound | 4 - 1 | Guelph StormGuelph Storm |
| 27 Apr 22 | r00        | Guelph StormGuelph Storm | 6 - 3 | Soo GreyhoundsSoo Greyhound |
| 29 Apr 22 | r00        | Guelph StormGuelph Storm | 4 - 5 | Soo GreyhoundsSoo Greyhound |
| 01 May 22 | r00        | Soo GreyhoundsSoo Greyhound | 6 - 0 | Guelph StormGuelph Storm |
| 07 May 22 | r00        | Flint FirebirdsFlint Firebir | 5 - 3 | Soo GreyhoundsSoo Greyhound |
| 08 May 22 | r00        | Flint FirebirdsFlint Firebir | 5 - 3 | Soo GreyhoundsSoo Greyhound |
| 11 May 22 | r00        | Soo GreyhoundsSoo Greyhound | 3 - 2 | Flint FirebirdsFlint Firebir |
| 13 May 22 | r00        | Soo GreyhoundsSoo Greyhound | 2 - 3 | Flint FirebirdsFlint Firebir |
| 15 May 22 | r00        | Flint FirebirdsFlint Firebir | 7 - 1 | Soo GreyhoundsSoo Greyhound |