| 04 Sep 21 | r00        | Erie OttersErie Otters | 5 - 4 | Saginaw SpiritSaginaw Spiri |
| 17 Sep 21 | r00        | Erie OttersErie Otters | 10 - 2 | Flint FirebirdsFlint Firebir |
| 19 Sep 21 | r00        | Erie OttersErie Otters | 7 - 4 | Saginaw SpiritSaginaw Spiri |
| 02 Oct 21 | r00        | Saginaw SpiritSaginaw Spiri | 3 - 1 | Erie OttersErie Otters |
| 02 Oct 21 | r00        | Flint FirebirdsFlint Firebir | 7 - 6 | Erie OttersErie Otters |
| 10 Oct 21 | r00        | Flint FirebirdsFlint Firebir | 3 - 0 | Erie OttersErie Otters |
| 15 Oct 21 | r00        | Flint FirebirdsFlint Firebir | 3 - 2 | Erie OttersErie Otters |
| 17 Oct 21 | r00        | Saginaw SpiritSaginaw Spiri | 2 - 4 | Erie OttersErie Otters |
| 17 Oct 21 | r00        | Saginaw SpiritSaginaw Spiri | 2 - 1 | Erie OttersErie Otters |
| 24 Oct 21 | r00        | Erie OttersErie Otters | 4 - 3 | Saginaw SpiritSaginaw Spiri |
| 24 Oct 21 | r00        | Erie OttersErie Otters | 4 - 6 | Saginaw SpiritSaginaw Spiri |
| 30 Oct 21 | r00        | Erie OttersErie Otters | 1 - 2 | Flint FirebirdsFlint Firebir |
| 31 Oct 21 | r00        | Erie OttersErie Otters | 2 - 6 | Flint FirebirdsFlint Firebir |
| 04 Nov 21 | r00        | Niagara IceDogsNiagara IceDo | 4 - 6 | Erie OttersErie Otters |
| 06 Nov 21 | r00        | Windsor SpitfiresWindsor Spitf | 3 - 2 | Erie OttersErie Otters |
| 07 Nov 21 | r00        | Sarnia StingSarnia Sting | 4 - 1 | Erie OttersErie Otters |
| 13 Nov 21 | r00        | Guelph StormGuelph Storm | 4 - 3 | Erie OttersErie Otters |
| 14 Nov 21 | r00        | Erie OttersErie Otters | 4 - 7 | London KnightsLondon Knight |
| 19 Nov 21 | r00        | Windsor SpitfiresWindsor Spitf | 4 - 7 | Erie OttersErie Otters |
| 20 Nov 21 | r00        | Flint FirebirdsFlint Firebir | 6 - 2 | Erie OttersErie Otters |
| 21 Nov 21 | r00        | Soo GreyhoundsSoo Greyhound | 5 - 4 | Erie OttersErie Otters |
| 26 Nov 21 | r00        | Erie OttersErie Otters | 5 - 3 | Soo GreyhoundsSoo Greyhound |
| 28 Nov 21 | r00        | Erie OttersErie Otters | 2 - 3 | Guelph StormGuelph Storm |
| 28 Nov 21 | r00        | Guelph StormGuelph Storm | 7 - 3 | Erie OttersErie Otters |
| 03 Dec 21 | r00        | Windsor SpitfiresWindsor Spitf | 4 - 5 | Erie OttersErie Otters |
| 04 Dec 21 | r00        | London KnightsLondon Knight | 4 - 1 | Erie OttersErie Otters |
| 05 Dec 21 | r00        | Hamilton BulldogsHamilton Bull | 3 - 2 | Erie OttersErie Otters |
| 09 Dec 21 | r00        | Flint FirebirdsFlint Firebir | 9 - 6 | Erie OttersErie Otters |
| 12 Dec 21 | r00        | Erie OttersErie Otters | 3 - 5 | Saginaw SpiritSaginaw Spiri |
| 12 Dec 21 | r00        | Erie OttersErie Otters | 4 - 3 | Sarnia StingSarnia Sting |
| 31 Dec 21 | r00        | Hamilton BulldogsHamilton Bull | 2 - 7 | Erie OttersErie Otters |
| 08 Jan 22 | r00        | Kitchener RangersKitchener Ran | 2 - 3 | Erie OttersErie Otters |
| 08 Jan 22 | r00        | Kitchener RangersKitchener Ran | 1 - 4 | Erie OttersErie Otters |
| 14 Jan 22 | r00        | Erie OttersErie Otters | 3 - 6 | Flint FirebirdsFlint Firebir |
| 17 Jan 22 | r00        | Erie OttersErie Otters | 6 - 4 | Saginaw SpiritSaginaw Spiri |
| 22 Jan 22 | r00        | London KnightsLondon Knight | 6 - 2 | Erie OttersErie Otters |
| 23 Jan 22 | r00        | Erie OttersErie Otters | 4 - 5 | Saginaw SpiritSaginaw Spiri |
| 23 Jan 22 | r00        | Erie OttersErie Otters | 4 - 2 | Saginaw SpiritSaginaw Spiri |
| 28 Jan 22 | r00        | Niagara IceDogsNiagara IceDo | 3 - 4 | Erie OttersErie Otters |
| 05 Feb 22 | r00        | Sarnia StingSarnia Sting | 2 - 5 | Erie OttersErie Otters |
| 06 Feb 22 | r00        | Saginaw SpiritSaginaw Spiri | 3 - 4 | Erie OttersErie Otters |
| 06 Feb 22 | r00        | Saginaw SpiritSaginaw Spiri | 5 - 1 | Erie OttersErie Otters |
| 09 Feb 22 | r00        | Erie OttersErie Otters | 7 - 4 | Owen Sound AttackOwen Sound At |
| 10 Feb 22 | r00        | Erie OttersErie Otters | 5 - 3 | Owen Sound AttackOwen Sound At |
| 13 Feb 22 | r00        | Erie OttersErie Otters | 1 - 5 | Flint FirebirdsFlint Firebir |
| 17 Feb 22 | r00        | Erie OttersErie Otters | 6 - 2 | Niagara IceDogsNiagara IceDo |
| 19 Feb 22 | r00        | Erie OttersErie Otters | 3 - 6 | Hamilton BulldogsHamilton Bull |
| 20 Feb 22 | r00        | Erie OttersErie Otters | 2 - 3 | London KnightsLondon Knight |
| 21 Feb 22 | r00        | Hamilton BulldogsHamilton Bull | 7 - 2 | Erie OttersErie Otters |
| 26 Feb 22 | r00        | Saginaw SpiritSaginaw Spiri | 8 - 1 | Erie OttersErie Otters |
| 27 Feb 22 | r00        | Saginaw SpiritSaginaw Spiri | 0 - 2 | Erie OttersErie Otters |
| 27 Feb 22 | r00        | Flint FirebirdsFlint Firebir | 3 - 7 | Erie OttersErie Otters |
| 05 Mar 22 | r00        | Erie OttersErie Otters | 2 - 3 | Flint FirebirdsFlint Firebir |
| 06 Mar 22 | r00        | Erie OttersErie Otters | 5 - 3 | Flint FirebirdsFlint Firebir |
| 10 Mar 22 | r00        | Erie OttersErie Otters | 4 - 1 | Niagara IceDogsNiagara IceDo |
| 12 Mar 22 | r00        | Erie OttersErie Otters | 6 - 4 | Windsor SpitfiresWindsor Spitf |
| 13 Mar 22 | r00        | Erie OttersErie Otters | 4 - 5 | Windsor SpitfiresWindsor Spitf |
| 14 Mar 22 | r00        | Guelph StormGuelph Storm | 4 - 3 | Erie OttersErie Otters |
| 18 Mar 22 | r00        | Kitchener RangersKitchener Ran | 4 - 3 | Erie OttersErie Otters |
| 19 Mar 22 | r00        | Owen Sound AttackOwen Sound At | 4 - 2 | Erie OttersErie Otters |
| 20 Mar 22 | r00        | Owen Sound AttackOwen Sound At | 5 - 1 | Erie OttersErie Otters |
| 24 Mar 22 | r00        | Niagara IceDogsNiagara IceDo | 7 - 4 | Erie OttersErie Otters |
| 26 Mar 22 | r00        | Erie OttersErie Otters | 4 - 1 | Guelph StormGuelph Storm |
| 27 Mar 22 | r00        | Erie OttersErie Otters | 1 - 3 | Niagara IceDogsNiagara IceDo |
| 02 Apr 22 | r00        | Erie OttersErie Otters | 0 - 3 | Hamilton BulldogsHamilton Bull |
| 03 Apr 22 | r00        | Erie OttersErie Otters | 4 - 3 | Kitchener RangersKitchener Ran |
| 03 Apr 22 | r00        | Erie OttersErie Otters | 6 - 2 | Kitchener RangersKitchener Ran |
| 07 Apr 22 | r00        | Erie OttersErie Otters | 4 - 5 | Sarnia StingSarnia Sting |
| 10 Apr 22 | r00        | Flint FirebirdsFlint Firebir | 4 - 1 | Erie OttersErie Otters |
| 11 Apr 22 | r00        | Erie OttersErie Otters | 2 - 3 | Kitchener RangersKitchener Ran |
| 12 Apr 22 | r00        | Erie OttersErie Otters | 1 - 4 | Guelph StormGuelph Storm |
| 16 Apr 22 | r00        | Erie OttersErie Otters | 3 - 2 | Windsor SpitfiresWindsor Spitf |
| 17 Apr 22 | r00        | Erie OttersErie Otters | 2 - 10 | Hamilton BulldogsHamilton Bull |