| 18 Sep 21 | r01        | Paderborn BasketsPaderborn Bas | 98 - 81 | Ehingen UrspringEhingen Urspr |
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| 25 Sep 21 | r02        | Gladiators TrevesGladiators Tr | 89 - 75 | Paderborn BasketsPaderborn Bas |
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| 02 Oct 21 | r03        | Paderborn BasketsPaderborn Bas | 73 - 72 | Phoenix HagenPhoenix Hagen |
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| 09 Oct 21 | r04        | Paderborn BasketsPaderborn Bas | 82 - 73 | Tigers TübingenTigers Tübing |
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| 16 Oct 21 | r05        | Paderborn BasketsPaderborn Bas | 99 - 86 | Rasta VechtaRasta Vechta |
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| 23 Oct 21 | r06        | Science City JenaScience City | 92 - 84 | Paderborn BasketsPaderborn Bas |
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| 30 Oct 21 | r07        | Paderborn BasketsPaderborn Bas | 89 - 115 | BremerhavenBremerhaven |
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| 05 Nov 21 | r08        | Paderborn BasketsPaderborn Bas | 86 - 92 | Panthers SchwenningenPanthers Schw |
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| 07 Nov 21 | r09        | PS Karlsruhe LionsPS Karlsruhe | 57 - 88 | Paderborn BasketsPaderborn Bas |
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| 13 Nov 21 | r10        | Paderborn BasketsPaderborn Bas | 86 - 81 | VfL SparkassenStars BochuVfL Sparkasse |
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| 20 Nov 21 | r11        | Rostock SeawolvesRostock Seawo | 107 - 68 | Paderborn BasketsPaderborn Bas |
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| 04 Dec 21 | r12        | Paderborn BasketsPaderborn Bas | 84 - 67 | VfL Kirchheim KnightsVfL Kirchheim |
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| 17 Dec 21 | r14        | Paderborn BasketsPaderborn Bas | 82 - 88 | Nürnberg Falcons BCNürnberg Falc |
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| 23 Dec 21 | r15        | Artland DragonsArtland Drago | 97 - 89 | Paderborn BasketsPaderborn Bas |
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| 26 Dec 21 | r16        | Paderborn BasketsPaderborn Bas | 101 - 89 | Bayer Giants LeverkusenBayer Giants |
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| 02 Jan 22 | r17        | Itzehoe EaglesItzehoe Eagle | 90 - 92 | Paderborn BasketsPaderborn Bas |
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| 08 Jan 22 | r18        | Rasta VechtaRasta Vechta | 87 - 96 | Paderborn BasketsPaderborn Bas |
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| 16 Jan 22 | r20        | Panthers SchwenningenPanthers Schw | 111 - 104 | Paderborn BasketsPaderborn Bas |
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| 12 Feb 22 | r25        | Tigers TübingenTigers Tübing | 82 - 86 | Paderborn BasketsPaderborn Bas |
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| 16 Feb 22 | r24        | Phoenix HagenPhoenix Hagen | 103 - 81 | Paderborn BasketsPaderborn Bas |
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| 19 Feb 22 | r26        | VfL SparkassenStars BochuVfL Sparkasse | 102 - 106 | Paderborn BasketsPaderborn Bas |
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| 26 Feb 22 | r19        | Paderborn BasketsPaderborn Bas | 99 - 89 | Artland DragonsArtland Drago |
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| 04 Mar 22 | r27        | Paderborn BasketsPaderborn Bas | 81 - 85 | PS Karlsruhe LionsPS Karlsruhe |
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| 06 Mar 22 | r28        | VfL Kirchheim KnightsVfL Kirchheim | 71 - 58 | Paderborn BasketsPaderborn Bas |
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| 13 Mar 22 | r29        | BremerhavenBremerhaven | 80 - 87 | Paderborn BasketsPaderborn Bas |
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| 16 Mar 22 | r23        | Paderborn BasketsPaderborn Bas | 99 - 94 | Science City JenaScience City |
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| 19 Mar 22 | r30        | Paderborn BasketsPaderborn Bas | 79 - 82 | Rostock SeawolvesRostock Seawo |
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| 25 Mar 22 | r31        | Paderborn BasketsPaderborn Bas | 104 - 88 | Gladiators TrevesGladiators Tr |
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| 27 Mar 22 | r32        | Ehingen UrspringEhingen Urspr | 73 - 85 | Paderborn BasketsPaderborn Bas |
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| 02 Apr 22 | r33        | Paderborn BasketsPaderborn Bas | 98 - 80 | Itzehoe EaglesItzehoe Eagle |
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| 06 Apr 22 | r22        | Nürnberg Falcons BCNürnberg Falc | 71 - 87 | Paderborn BasketsPaderborn Bas |
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| 09 Apr 22 | r34        | Bayer Giants LeverkusenBayer Giants | 102 - 85 | Paderborn BasketsPaderborn Bas |
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| 22 Apr 22 | r00        | Science City JenaScience City | 89 - 84 | Paderborn BasketsPaderborn Bas |
| 24 Apr 22 | r00        | Paderborn BasketsPaderborn Bas | 100 - 84 | Science City JenaScience City |
| 27 Apr 22 | r00        | Science City JenaScience City | 84 - 83 | Paderborn BasketsPaderborn Bas |
| 29 Apr 22 | r00        | Paderborn BasketsPaderborn Bas | 91 - 86 | Science City JenaScience City |
| 01 May 22 | r00        | Science City JenaScience City | 73 - 59 | Paderborn BasketsPaderborn Bas |