| 19 Sep 21 | r01        | Bayer Giants LeverkusenBayer Giants | 109 - 71 | PS Karlsruhe LionsPS Karlsruhe |
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| 25 Sep 21 | r02        | PS Karlsruhe LionsPS Karlsruhe | 97 - 70 | VfL Kirchheim KnightsVfL Kirchheim |
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| 02 Oct 21 | r03        | PS Karlsruhe LionsPS Karlsruhe | 75 - 96 | Gladiators TrevesGladiators Tr |
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| 09 Oct 21 | r04        | Phoenix HagenPhoenix Hagen | 78 - 86 | PS Karlsruhe LionsPS Karlsruhe |
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| 23 Oct 21 | r06        | Itzehoe EaglesItzehoe Eagle | 87 - 92 | PS Karlsruhe LionsPS Karlsruhe |
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| 30 Oct 21 | r07        | PS Karlsruhe LionsPS Karlsruhe | 75 - 85 | Tigers TübingenTigers Tübing |
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| 05 Nov 21 | r08        | Nürnberg Falcons BCNürnberg Falc | 89 - 83 | PS Karlsruhe LionsPS Karlsruhe |
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| 07 Nov 21 | r09        | PS Karlsruhe LionsPS Karlsruhe | 57 - 88 | Paderborn BasketsPaderborn Bas |
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| 13 Nov 21 | r10        | Science City JenaScience City | 113 - 109 | PS Karlsruhe LionsPS Karlsruhe |
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| 04 Dec 21 | r12        | Rasta VechtaRasta Vechta | 99 - 107 | PS Karlsruhe LionsPS Karlsruhe |
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| 11 Dec 21 | r13        | PS Karlsruhe LionsPS Karlsruhe | 82 - 68 | Panthers SchwenningenPanthers Schw |
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| 18 Dec 21 | r14        | PS Karlsruhe LionsPS Karlsruhe | 109 - 94 | VfL SparkassenStars BochuVfL Sparkasse |
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| 23 Dec 21 | r15        | Ehingen UrspringEhingen Urspr | 91 - 111 | PS Karlsruhe LionsPS Karlsruhe |
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| 26 Dec 21 | r16        | PS Karlsruhe LionsPS Karlsruhe | 87 - 86 | Rostock SeawolvesRostock Seawo |
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| 02 Jan 22 | r17        | Artland DragonsArtland Drago | 84 - 88 | PS Karlsruhe LionsPS Karlsruhe |
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| 06 Jan 22 | r11        | PS Karlsruhe LionsPS Karlsruhe | 84 - 96 | BremerhavenBremerhaven |
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| 08 Jan 22 | r18        | PS Karlsruhe LionsPS Karlsruhe | 89 - 85 | Itzehoe EaglesItzehoe Eagle |
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| 14 Jan 22 | r19        | PS Karlsruhe LionsPS Karlsruhe | 93 - 88 | Phoenix HagenPhoenix Hagen |
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| 16 Jan 22 | r20        | VfL Kirchheim KnightsVfL Kirchheim | 76 - 74 | PS Karlsruhe LionsPS Karlsruhe |
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| 22 Jan 22 | r21        | PS Karlsruhe LionsPS Karlsruhe | 94 - 106 | Science City JenaScience City |
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| 29 Jan 22 | r22        | Gladiators TrevesGladiators Tr | 104 - 82 | PS Karlsruhe LionsPS Karlsruhe |
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| 05 Feb 22 | r23        | PS Karlsruhe LionsPS Karlsruhe | 99 - 77 | Bayer Giants LeverkusenBayer Giants |
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| 09 Feb 22 | r24        | PS Karlsruhe LionsPS Karlsruhe | 114 - 65 | Ehingen UrspringEhingen Urspr |
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| 19 Feb 22 | r26        | BremerhavenBremerhaven | 94 - 101 | PS Karlsruhe LionsPS Karlsruhe |
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| 04 Mar 22 | r27        | Paderborn BasketsPaderborn Bas | 81 - 85 | PS Karlsruhe LionsPS Karlsruhe |
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| 06 Mar 22 | r28        | PS Karlsruhe LionsPS Karlsruhe | 88 - 98 | Rasta VechtaRasta Vechta |
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| 25 Mar 22 | r31        | PS Karlsruhe LionsPS Karlsruhe | 85 - 86 | Artland DragonsArtland Drago |
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| 27 Mar 22 | r32        | PS Karlsruhe LionsPS Karlsruhe | 90 - 84 | Nürnberg Falcons BCNürnberg Falc |
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| 02 Apr 22 | r33        | VfL SparkassenStars BochuVfL Sparkasse | 82 - 102 | PS Karlsruhe LionsPS Karlsruhe |
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| 04 Apr 22 | r30        | Tigers TübingenTigers Tübing | 112 - 85 | PS Karlsruhe LionsPS Karlsruhe |
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| 11 Apr 22 | r29        | Panthers SchwenningenPanthers Schw | 73 - 94 | PS Karlsruhe LionsPS Karlsruhe |
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| 19 Apr 22 | r34        | Rostock SeawolvesRostock Seawo | 73 - 80 | PS Karlsruhe LionsPS Karlsruhe |
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| 23 Apr 22 | r00        | PS Karlsruhe LionsPS Karlsruhe | 66 - 87 | Rostock SeawolvesRostock Seawo |
| 26 Apr 22 | r00        | Rostock SeawolvesRostock Seawo | 107 - 103 | PS Karlsruhe LionsPS Karlsruhe |
| 28 Apr 22 | r00        | Rostock SeawolvesRostock Seawo | 81 - 72 | PS Karlsruhe LionsPS Karlsruhe |