| 09 Oct 21 | r00  | Manchester MysticsManchester My | 46 - 79 | Sheffield HattersSheffield Hat |
| 16 Oct 21 | r00 | Manchester MysticsManchester My | 85 - 64 | Caledonia PrideCaledonia Pri |
| 17 Oct 21 | r00 | Gloucester City QueensGloucester Ci | 66 - 69 | Manchester MysticsManchester My |
| 23 Oct 21 | r00 | Manchester MysticsManchester My | 78 - 71 | Cardiff Met ArchersCardiff Met A |
| 30 Oct 21 | r00 | Essex RebelsEssex Rebels | 100 - 60 | Manchester MysticsManchester My |
| 06 Nov 21 | r00 | Manchester MysticsManchester My | 84 - 79 | Nottingham WildcatsNottingham Wi |
| 20 Nov 21 | r00 | Manchester MysticsManchester My | 65 - 49 | Oaklands WolvesOaklands Wolv |
| 05 Dec 21 | r00 | Manchester MysticsManchester My | 51 - 80 | Sevenoaks SunsSevenoaks Sun |
| 11 Dec 21 | r00 | Manchester MysticsManchester My | 60 - 53 | Leicester Riders WomenLeicester Rid |
| 08 Jan 22 | r00 | Manchester MysticsManchester My | 52 - 59 | Newcastle Eagles WomenNewcastle Eag |
| 22 Jan 22 | r00 | Sevenoaks SunsSevenoaks Sun | 80 - 41 | Manchester MysticsManchester My |
| 19 Feb 22 | r00 | Nottingham WildcatsNottingham Wi | 95 - 79 | Manchester MysticsManchester My |
| 26 Feb 22 | r00 | Cardiff Met ArchersCardiff Met A | 49 - 70 | Manchester MysticsManchester My |
| 05 Mar 22 | r00 | Manchester MysticsManchester My | 86 - 53 | Gloucester City QueensGloucester Ci |
| 12 Mar 22 | r00 | Caledonia PrideCaledonia Pri | 75 - 53 | Manchester MysticsManchester My |
| 26 Mar 22 | r00 | Manchester MysticsManchester My | 77 - 80 | Essex RebelsEssex Rebels |
| 27 Mar 22 | r00 | Newcastle Eagles WomenNewcastle Eag | 70 - 85 | Manchester MysticsManchester My |
| 03 Apr 22 | r00 | Oaklands WolvesOaklands Wolv | 59 - 67 | Manchester MysticsManchester My |
| 09 Apr 22 | r00 | Manchester MysticsManchester My | 58 - 64 | Durham PalatinatesDurham Palati |
| 10 Apr 22 | r00 | London Lions WomenLondon Lions | 96 - 48 | Manchester MysticsManchester My |
| 16 Apr 22 | r00 | Sheffield HattersSheffield Hat | 99 - 64 | Manchester MysticsManchester My |
| 17 Apr 22 | r00 | Durham PalatinatesDurham Palati | 68 - 55 | Manchester MysticsManchester My |
| 20 Apr 22 | r00 | Manchester MysticsManchester My | 38 - 103 | London Lions WomenLondon Lions |
| 24 Apr 22 | r00 | Leicester Riders WomenLeicester Rid | 97 - 102 | Manchester MysticsManchester My |
Team 2021-2022 Schedules
Caledonia Gladiators
Cardiff Met Archers
Essex Rebels
Leicester Riders Women
London Lions Women
Manchester Basketball Women
Newcastle Eagles Women
Nottingham Wildcats
Oaklands Wolves
Sheffield Hatters
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