| 05 Sep 21 | r01  | Eibar WomenEibar Women | 3 - 2 | Sevilla WomenSevilla Women |
| |
| 12 Sep 21 | r02  | Sevilla WomenSevilla Women | 0 - 0 | Levante WomenLevante Women |
| |
| 25 Sep 21 | r03 | Real Sociedad WomenReal Sociedad | 2 - 0 | Sevilla WomenSevilla Women |
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| 29 Sep 21 | r04 | Sevilla WomenSevilla Women | 2 - 2 | Madrid CFFMadrid CFF |
| |
| 03 Oct 21 | r05 | Valencia WomenValencia Wome | 1 - 2 | Sevilla WomenSevilla Women |
| |
| 10 Oct 21 | r06 | Sevilla WomenSevilla Women | 0 - 0 | Athletic Club WomenAthletic Club |
| |
| 16 Oct 21 | r07 | Sevilla WomenSevilla Women | 3 - 0 | Real Madrid WomenReal Madrid W |
| |
| 31 Oct 21 | r08 | Rayo Vallecano WomenRayo Vallecan | 1 - 0 | Sevilla WomenSevilla Women |
| |
| 06 Nov 21 | r09 | Sevilla WomenSevilla Women | 1 - 0 | Alavés GloriosasAlavés Glorio |
| |
| 14 Nov 21 | r10 | Villarreal WomenVillarreal Wo | 2 - 3 | Sevilla WomenSevilla Women |
| |
| 20 Nov 21 | r11 | Sevilla WomenSevilla Women | 1 - 10 | Barcelona FemeníBarcelona Fem |
| |
| 04 Dec 21 | r12 | Betis FéminasBetis Féminas | 0 - 0 | Sevilla WomenSevilla Women |
| |
| 12 Dec 21 | r13 | Sevilla WomenSevilla Women | 0 - 0 | Atlético Madrid FemeninoAtlético Madr |
| |
| 18 Dec 21 | r14 | Sporting de HuelvaSporting de H | 0 - 0 | Sevilla WomenSevilla Women |
| |
| 22 Dec 21 | r15 | Sevilla WomenSevilla Women | 1 - 2 | GranadillaGranadilla |
| |
| 08 Jan 22 | r16 | Madrid CFFMadrid CFF | 1 - 2 | Sevilla WomenSevilla Women |
| |
| 12 Jan 22 | r17 | Sevilla WomenSevilla Women | 2 - 1 | Rayo Vallecano WomenRayo Vallecan |
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| 16 Jan 22 | r18 | Sevilla WomenSevilla Women | 3 - 1 | Valencia WomenValencia Wome |
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| 29 Jan 22 | r19  | Real Madrid WomenReal Madrid W | 3 - 1 | Sevilla WomenSevilla Women |
| |
| 02 Feb 22 | r20 | Sevilla WomenSevilla Women | 0 - 3 | Villarreal WomenVillarreal Wo |
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| 06 Feb 22 | r21 | Alavés GloriosasAlavés Glorio | 1 - 1 | Sevilla WomenSevilla Women |
| |
| 13 Feb 22 | r22 | Atlético Madrid FemeninoAtlético Madr | 5 - 0 | Sevilla WomenSevilla Women |
| |
| 06 Mar 22 | r23 | Sevilla WomenSevilla Women | 0 - 0 | Betis FéminasBetis Féminas |
| |
| 13 Mar 22 | r24 | GranadillaGranadilla | 1 - 0 | Sevilla WomenSevilla Women |
| |
| 26 Mar 22 | r25 | Sevilla WomenSevilla Women | 4 - 1 | Eibar WomenEibar Women |
| |
| 03 Apr 22 | r26 | Levante WomenLevante Women | 3 - 0 | Sevilla WomenSevilla Women |
| |
| 16 Apr 22 | r27 | Sevilla WomenSevilla Women | 1 - 2 | Real Sociedad WomenReal Sociedad |
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| 05 May 22 | r28 | Barcelona FemeníBarcelona Fem | 5 - 1 | Sevilla WomenSevilla Women |
| |
| 08 May 22 | r29 | Sevilla WomenSevilla Women | 3 - 1 | Sporting de HuelvaSporting de H |
| |
| 15 May 22 | r30 | Athletic Club WomenAthletic Club | 1 - 4 | Sevilla WomenSevilla Women |
Team 2021-2022 Schedules
Alhama
Athletic Club Women
Atlético Madrid Femenino
Badalona Women
Barcelona Femení
Deportivo de La Coruña Women
DUX Logroño
Eibar Women
Espanyol Femení
Granada Femenino
Levante Femenino
Madrid CFF
Real Madrid Femenino
Real Sociedad Femenino
Sevilla Women
Tenerife Femenino
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