| 05 Sep 21 | r01   | Levante WomenLevante Women | 4 - 0 | Real Madrid WomenReal Madrid W |
| |
| 12 Sep 21 | r02 | Real Madrid WomenReal Madrid W | 0 - 2 | Atlético Madrid FemeninoAtlético Madr |
| |
| 25 Sep 21 | r03 | GranadillaGranadilla | 1 - 1 | Real Madrid WomenReal Madrid W |
| |
| 29 Sep 21 | r04 | Real Madrid WomenReal Madrid W | 0 - 1 | Real Sociedad WomenReal Sociedad |
| |
| 03 Oct 21 | r05 | Athletic Club WomenAthletic Club | 2 - 0 | Real Madrid WomenReal Madrid W |
| |
| 10 Oct 21 | r06 | Real Madrid WomenReal Madrid W | 2 - 1 | Eibar WomenEibar Women |
| |
| 16 Oct 21 | r07 | Sevilla WomenSevilla Women | 3 - 0 | Real Madrid WomenReal Madrid W |
| |
| 31 Oct 21 | r08 | Real Madrid WomenReal Madrid W | 2 - 1 | Valencia WomenValencia Wome |
| |
| 06 Nov 21 | r09 | Real Madrid WomenReal Madrid W | 1 - 0 | Rayo Vallecano WomenRayo Vallecan |
| |
| 13 Nov 21 | r10 | Betis FéminasBetis Féminas | 1 - 4 | Real Madrid WomenReal Madrid W |
| |
| 21 Nov 21 | r11 | Real Madrid WomenReal Madrid W | 1 - 1 | Alavés GloriosasAlavés Glorio |
| |
| 04 Dec 21 | r12 | Villarreal WomenVillarreal Wo | 0 - 2 | Real Madrid WomenReal Madrid W |
| |
| 12 Dec 21 | r13 | Real Madrid WomenReal Madrid W | 1 - 3 | Barcelona FemeníBarcelona Fem |
| |
| 19 Dec 21 | r14 | Madrid CFFMadrid CFF | 1 - 3 | Real Madrid WomenReal Madrid W |
| |
| 22 Dec 21 | r15 | Real Madrid WomenReal Madrid W | 3 - 0 | Sporting de HuelvaSporting de H |
| |
| 29 Jan 22 | r19  | Real Madrid WomenReal Madrid W | 3 - 1 | Sevilla WomenSevilla Women |
| |
| 02 Feb 22 | r20 | Real Sociedad WomenReal Sociedad | 1 - 3 | Real Madrid WomenReal Madrid W |
| |
| 06 Feb 22 | r21 | Real Madrid WomenReal Madrid W | 1 - 0 | Betis FéminasBetis Féminas |
| |
| 13 Feb 22 | r22 | Eibar WomenEibar Women | 0 - 2 | Real Madrid WomenReal Madrid W |
| |
| 05 Mar 22 | r23 | Real Madrid WomenReal Madrid W | 2 - 0 | Athletic Club WomenAthletic Club |
| |
| 09 Mar 22 | r16 | Atlético Madrid FemeninoAtlético Madr | 0 - 2 | Real Madrid WomenReal Madrid W |
| |
| 13 Mar 22 | r24 | Barcelona FemeníBarcelona Fem | 5 - 0 | Real Madrid WomenReal Madrid W |
| |
| 19 Mar 22 | r17 | Real Madrid WomenReal Madrid W | 2 - 0 | GranadillaGranadilla |
| |
| 26 Mar 22 | r25 | Real Madrid WomenReal Madrid W | 1 - 0 | Levante WomenLevante Women |
| |
| 03 Apr 22 | r26 | Sporting de HuelvaSporting de H | 3 - 1 | Real Madrid WomenReal Madrid W |
| |
| 17 Apr 22 | r27 | Alavés GloriosasAlavés Glorio | 0 - 1 | Real Madrid WomenReal Madrid W |
| |
| 20 Apr 22 | r18 | Rayo Vallecano WomenRayo Vallecan | 0 - 1 | Real Madrid WomenReal Madrid W |
| |
| 01 May 22 | r28 | Real Madrid WomenReal Madrid W | 1 - 0 | Madrid CFFMadrid CFF |
| |
| 08 May 22 | r29 | Valencia WomenValencia Wome | 0 - 0 | Real Madrid WomenReal Madrid W |
| |
| 15 May 22 | r30 | Real Madrid WomenReal Madrid W | 1 - 0 | Villarreal WomenVillarreal Wo |
Team 2021-2022 Schedules
Alhama
Athletic Club Women
Atlético Madrid Femenino
Badalona Women
Barcelona Femení
Deportivo de La Coruña Women
DUX Logroño
Eibar Women
Espanyol Femení
Granada Femenino
Levante Femenino
Madrid CFF
Real Madrid Femenino
Real Sociedad Femenino
Sevilla Women
Tenerife Femenino
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