| 09 Nov 21 |
r19        | Berwick RangersBerwick Range | 3 - 0 | Edinburgh UniversityEdinburgh Uni |
| 09 Nov 21 |
r19        | Caledonian BravesCaledonian Br | 1 - 2 | Civil Service StrollersCivil Service |
| 09 Nov 21 |
r19        | Gala Fairydean RoversGala Fairydea | 3 - 1 | Gretna 2008Gretna 2008 |
| 09 Nov 21 |
r19        | Bonnyrigg Rose AthleticBonnyrigg Ros | 2 - 0 | Vale of LeithenVale of Leith |
| 10 Nov 21 |
r19        | BroomhillBroomhill | 1 - 2 | Boness UnitedBoness United |
| 10 Nov 21 |
r19        | Cumbernauld ColtsCumbernauld C | 2 - 3 | Rangers BRangers B |
| 10 Nov 21 |
r19        | Dalbeattie StarDalbeattie St | 1 - 4 | East KilbrideEast Kilbride |
| 10 Nov 21 |
r19        | East StirlingshireEast Stirling | 1 - 1 | University of StirlingUniversity of |