| 05 Sep 21 | r41  | MontijoMontijo | 0 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 12 Sep 21 | r42 | Las Palmas AtléticoLas Palmas At | 2 - 2 | Panadería PulidoPanadería Pul |
| |
| 19 Sep 21 | r43 | AD Ceuta FCAD Ceuta FC | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| |
| 26 Sep 21 | r44 | Las Palmas AtléticoLas Palmas At | 2 - 0 | VélezVélez |
| |
| 03 Oct 21 | r45 | Xerez DeportivoXerez Deporti | 2 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 10 Oct 21 | r46 | Las Palmas AtléticoLas Palmas At | 1 - 1 | Cadiz BCadiz B |
| |
| 17 Oct 21 | r47 | CD CoriaCD Coria | 3 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 24 Oct 21 | r48 | Las Palmas AtléticoLas Palmas At | 1 - 4 | Don BenitoDon Benito |
| |
| 31 Oct 21 | r49 | TamaraceiteTamaraceite | 0 - 0 | Las Palmas AtléticoLas Palmas At |
| |
| 07 Nov 21 | r410 | Las Palmas AtléticoLas Palmas At | 1 - 0 | UD San FernandoUD San Fernan |
| |
| 14 Nov 21 | r411 | MensajeroMensajero | 1 - 2 | Las Palmas AtléticoLas Palmas At |
| |
| 21 Nov 21 | r412 | Las Palmas AtléticoLas Palmas At | 1 - 2 | AntequeraAntequera |
| |
| 28 Nov 21 | r413 | San Roque LepeSan Roque Lep | 1 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 05 Dec 21 | r414 | Las Palmas AtléticoLas Palmas At | 2 - 2 | CordobaCordoba |
| |
| 12 Dec 21 | r415 | CacereñoCacereño | 3 - 2 | Las Palmas AtléticoLas Palmas At |
| |
| 19 Dec 21 | r416 | Las Palmas AtléticoLas Palmas At | 1 - 1 | VillanovenseVillanovense |
| |
| 09 Jan 22 | r417 | Mérida ADMérida AD | 2 - 0 | Las Palmas AtléticoLas Palmas At |
| |
| 23 Jan 22 | r418 | Las Palmas AtléticoLas Palmas At | 0 - 3 | MontijoMontijo |
| |
| 30 Jan 22 | r419  | Panadería PulidoPanadería Pul | 1 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 06 Feb 22 | r420 | Las Palmas AtléticoLas Palmas At | 0 - 2 | AD Ceuta FCAD Ceuta FC |
| |
| 13 Feb 22 | r421 | VélezVélez | 1 - 0 | Las Palmas AtléticoLas Palmas At |
| |
| 20 Feb 22 | r422 | Las Palmas AtléticoLas Palmas At | 1 - 0 | Xerez DeportivoXerez Deporti |
| |
| 27 Feb 22 | r423 | Cadiz BCadiz B | 1 - 0 | Las Palmas AtléticoLas Palmas At |
| |
| 06 Mar 22 | r424 | Las Palmas AtléticoLas Palmas At | 3 - 1 | CD CoriaCD Coria |
| |
| 13 Mar 22 | r425 | Don BenitoDon Benito | 3 - 2 | Las Palmas AtléticoLas Palmas At |
| |
| 20 Mar 22 | r426 | Las Palmas AtléticoLas Palmas At | 3 - 3 | TamaraceiteTamaraceite |
| |
| 27 Mar 22 | r427 | UD San FernandoUD San Fernan | 3 - 2 | Las Palmas AtléticoLas Palmas At |
| |
| 03 Apr 22 | r428 | Las Palmas AtléticoLas Palmas At | 2 - 1 | MensajeroMensajero |
| |
| 10 Apr 22 | r429 | AntequeraAntequera | 3 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 16 Apr 22 | r430 | Las Palmas AtléticoLas Palmas At | 2 - 3 | San Roque LepeSan Roque Lep |
| |
| 24 Apr 22 | r431 | CordobaCordoba | 5 - 1 | Las Palmas AtléticoLas Palmas At |
| |
| 01 May 22 | r432 | Las Palmas AtléticoLas Palmas At | 1 - 2 | CacereñoCacereño |
| |
| 08 May 22 | r433 | VillanovenseVillanovense | 2 - 2 | Las Palmas AtléticoLas Palmas At |
| |
| 15 May 22 | r434 | Las Palmas AtléticoLas Palmas At | 1 - 3 | Mérida ADMérida AD |
Team 2021-2022 Schedules
Atlético Antoniano
Atlético Central
Atlético Paso
Atlético Sanluqueño
Badajoz
Betis Deportivo
Ciudad de Lucena
Don Benito
Estepona
Las Palmas Atlético
Linares Deportivo
Marbella
Mijas-Las Lagunas
Recreativo de Huelva
Sevilla Atlético
Tamaraceite
Tenerife B
Xerez
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